The use of prehospital blood products in the resuscitation of trauma patients: a review of prehospital transfusion practices and a description of our regional whole blood program in San Antonio, TX

2019 ◽  
Vol 14 (3) ◽  
pp. 332-342 ◽  
Author(s):  
Douglas M. Pokorny ◽  
Maxwell A. Braverman ◽  
Philip M. Edmundson ◽  
David M. Bittenbinder ◽  
Caroline S. Zhu ◽  
...  
Keyword(s):  
Whole Blood ◽  
San Antonio ◽  
Trauma Patients ◽  
Blood Products

scholarly journals Prehospital resuscitation

2021 ◽  
Vol 6 (1) ◽  
pp. e000729
Author(s):  
Alexandra M P Brito ◽  
Martin Schreiber
Keyword(s):  
Young People ◽  
Tranexamic Acid ◽  
New Technologies ◽  
Blood Product ◽  
Traumatic Injury ◽  
Trauma Patients ◽  
Blood Products ◽  
Front Line ◽  
The Usa ◽  
Review Current

Traumatic injury is the leading cause of death in young people in the USA. Our knowledge of prehospital resuscitation is constantly evolving and is often informed by research based on military experience. A move toward balanced blood product resuscitation and away from excessive crystalloid use has led to improvements in outcomes for trauma patients. This has been facilitated by new technologies allowing more front-line use of blood products as well as use of tranexamic acid in the prehospital setting. In this article, we review current practices in prehospital resuscitation and the studies that have informed these practices.

Autotransfusion of hemothorax blood in trauma patients: is it the same as fresh whole blood?

2011 ◽  
Vol 202 (6) ◽  
pp. 817-822 ◽  
Author(s):  
Marc Salhanick ◽  
Michael Corneille ◽  
Russell Higgins ◽  
John Olson ◽  
Joel Michalek ◽  
...  
Keyword(s):  
Whole Blood ◽  
Trauma Patients

scholarly journals Compatibility of Stabilized Whole Blood Products with CD4 Technologies and Their Suitability for Quality Assessment Programs

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e103391 ◽  
Author(s):  
Tao Ding ◽  
Michèle Bergeron ◽  
Peggy Seely ◽  
Xuefen Yang ◽  
Tamsir O. Diallo ◽  
...  
Keyword(s):  
Quality Assessment ◽  
Whole Blood ◽  
Blood Products

scholarly journals Prestorage leukocyte reduction with in-lin filtration system for whole blood(Sepacell Integra MAP): Evaluation of system efficiency and blood products.

2000 ◽  
Vol 46 (6) ◽  
pp. 521-531 ◽  
Author(s):  
Mitsuaki Akino ◽  
Sadamitsu Yamamoto ◽  
Satoshi Saikawa ◽  
Masako Satoh ◽  
Kimiko Segawa ◽  
...  
Keyword(s):  
Whole Blood ◽  
System Efficiency ◽  
Blood Products ◽  
Filtration System ◽  
Map Evaluation

The use of low-titer group O whole blood for the resuscitation of civilian trauma patients in 2018

Transfusion ◽  
2018 ◽  
Vol 58 (11) ◽  
pp. 2744-2746 ◽  
Author(s):  
Mark H. Yazer ◽  
Philip C. Spinella
Keyword(s):  
Whole Blood ◽  
Trauma Patients ◽  
Civilian Trauma ◽  
Titer Group

Prehospital Blood Product Administration Opportunities in Ground Transport ALS EMS – A Descriptive Study

2018 ◽  
Vol 33 (3) ◽  
pp. 230-236 ◽  
Author(s):  
Felicia M. Mix ◽  
Martin D. Zielinski ◽  
Lucas A. Myers ◽  
Kathy S. Berns ◽  
Anurahda Luke ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Patient Care ◽  
Blood Product ◽  
Life Support ◽  
Descriptive Study ◽  
Blood Product Transfusion ◽  
Trauma Patients ◽  
Blood Products ◽  
Total Patient ◽  
Significant Difference

AbstractIntroductionHemorrhage remains the major cause of preventable death after trauma. Recent data suggest that earlier blood product administration may improve outcomes. The purpose of this study was to determine whether opportunities exist for blood product transfusion by ground Emergency Medical Services (EMS).MethodsThis was a single EMS agency retrospective study of ground and helicopter responses from January 1, 2011 through December 31, 2015 for adult trauma patients transported from the scene of injury who met predetermined hemodynamic (HD) parameters for potential transfusion (heart rate [HR]≥120 and/or systolic blood pressure [SBP]≤90).ResultsA total of 7,900 scene trauma ground transports occurred during the study period. Of 420 patients meeting HD criteria for transfusion, 53 (12.6%) had a significant mechanism of injury (MOI). Outcome data were available for 51 patients; 17 received blood products during their emergency department (ED) resuscitation. The percentage of patients receiving blood products based upon HD criteria ranged from 1.0% (HR) to 5.9% (SBP) to 38.1% (HR+SBP). In all, 74 Helicopter EMS (HEMS) transports met HD criteria for blood transfusion, of which, 28 patients received prehospital blood transfusion. Statistically significant total patient care time differences were noted for both the HR and the SBP cohorts, with HEMS having longer time intervals; no statistically significant difference in mean total patient care time was noted in the HR+SBP cohort.ConclusionsIn this study population, HD parameters alone did not predict need for ED blood product administration. Despite longer transport times, only one-third of HEMS patients meeting HD criteria for blood administration received prehospital transfusion. While one-third of ground Advanced Life Support (ALS) transport patients manifesting HD compromise received blood products in the ED, this represented 0.2% of total trauma transports over the study period. Given complex logistical issues involved in prehospital blood product administration, opportunities for ground administration appear limited within the described system.MixFM, ZielinskiMD, MyersLA, BernsKS, LukeA, StubbsJR, ZietlowSP, JenkinsDH, SztajnkrycerMD. Prehospital blood product administration opportunities in ground transport ALS EMS – a descriptive study. Prehosp Disaster Med. 2018;33(3):230–236.

scholarly journals Effects of Blood Sample Age at Time of Separation on Measured Cytokine Concentrations in Human Plasma

2010 ◽  
Vol 18 (2) ◽  
pp. 318-326 ◽  
Author(s):  
Rachael P. Jackman ◽  
Garth H. Utter ◽  
John W. Heitman ◽  
Dale F. Hirschkorn ◽  
Jacqueline P. Law ◽  
...  
Keyword(s):  
Whole Blood ◽  
Peripheral Blood ◽  
Blood Protein ◽  
Blood Collection ◽  
Trauma Patients ◽  
Immune Mediators ◽  
Blood Cytokines ◽  
Wide Range ◽  
Significant Change ◽  
Sample Age

ABSTRACTMeasurement of peripheral blood cytokines and other immunomodulatory proteins is a useful and popular tool for assessing human immune responses to a wide range of assaults. A common challenge in this work is obtaining fresh, high-quality samples and limiting the time between blood collection and the separation of plasma or serum from cells. In this study we sought to determine the effect of sample age at the time of processing on the measured levels of 41 soluble immune mediators. Two cohorts were examined: healthy lab donors and trauma patients, who have significant immune perturbation. Whole-blood samples were aliquoted, and plasma was isolated, at days 0, 1, 2, and 3 after collection. Multiplexing techniques were used to measure protein concentrations, and general estimating equations were used to determine if there was a significant change over time. Over the 3-day period examined, only 15 of the 41 proteins showed no significant change in either cohort. Among the remaining proteins both increases and decreases were observed, with changes ranging from 2.4% per day to 325% per day. Proteins with significant changes in one cohort did not always show significant changes in the other group. These results support the need to separate plasma or serum from whole blood as quickly as possible and/or to standardize the length of time to processing within a given study of peripheral blood protein concentrations. When this is not possible, care should be taken to account for differences due to sample age.

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