scholarly journals Effect of red blood cell transfusion on inflammation, endothelial cell activation and coagulation in the critically ill

Vox Sanguinis ◽  
2021 ◽  
Author(s):  
Lisa Manen ◽  
Maike E. Hezel ◽  
Margit Boshuizen ◽  
Marleen Straat ◽  
Angelique M. E. Man ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Cell Activation ◽  
Red Blood Cell Transfusion ◽  
Endothelial Cell Activation

scholarly journals The Effect of Sex-Mismatched Red Blood Cell Transfusion on Endothelial Cell Activation in Critically Ill Patients

2021 ◽  
pp. 1-8
Author(s):  
Abdulrahman Alshalani ◽  
Lisa van Manen ◽  
Margit Boshuizen ◽  
Robin van Bruggen ◽  
Jason P. Acker ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Critically Ill Patients ◽  
Cell Activation ◽  
Endothelial Activation ◽  
Endothelial Cell Activation ◽  
Activation Markers ◽  
Matched Group

<b><i>Background:</i></b> Observational studies suggest that sex-mismatched transfusion is associated with increased mortality. Mechanisms driving mortality are not known but may include endothelial activation. The aim of this study is to investigate the effects of sex-mismatched red blood cell (RBC) transfusions on endothelial cell activation markers in critically ill patients. <b><i>Study Design and Methods:</i></b> In patients admitted to the intensive care unit who received a single RBC unit, blood samples were drawn before (T<sub>0</sub>), 1 h after (T<sub>1</sub>), and 24 h after transfusion (T<sub>24</sub>) for analysis of soluble syndecan-1, soluble intercellular adhesion molecule-1, soluble thrombomodulin (sTM), von Willebrand factor antigen, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNFα). Changes in the levels of these factors were compared between sex-matched and sex-mismatched groups. <b><i>Results:</i></b> Of 69 included patients, 32 patients were in the sex-matched and 37 patients were in the sex-mismatched group. Compared to baseline, sex-matched transfusion was associated with significant reduction in sTM level (<i>p</i> value = 0.03). Between-group comparison showed that levels of syndecan-1 and sTM were significantly higher in the sex-mismatched group compared to the sex-matched group at T<sub>24</sub> (<i>p</i> value = 0.04 and 0.01, respectively). Also, TNFα and IL-6 levels showed a statistically marginal significant increase compared to baseline in the sex-mismatched group at T<sub>24</sub> (<i>p</i> value = 0.06 and 0.05, respectively), but not in the sex-matched group. <b><i>Discussion:</i></b> Transfusion of a single sex-mismatched RBC unit was associated with higher syndecan-1 and sTM levels compared to transfusion of sex-matched RBC unit. These findings may suggest that sex-mismatched RBC transfusion is associated with endothelial activation.

scholarly journals Anemia and red blood cell transfusion in critically ill cardiac patients

2014 ◽  
Vol 4 (1) ◽  
pp. 16 ◽  
Author(s):  
Geneviève Du Pont-Thibodeau ◽  
Karen Harrington ◽  
Jacques Lacroix
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Cardiac Patients ◽  
Red Blood Cell Transfusion
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