Granulocyte transfusions could benefit patients with severe oral mucositis after allogeneic hematopoietic stem cell transplantation

Vox Sanguinis ◽  
2019 ◽  
Vol 114 (7) ◽  
pp. 769-777 ◽  
Author(s):  
Sofia Berglund ◽  
Emma Watz ◽  
Mats Remberger ◽  
Karin Garming Legert ◽  
Ulla Axdorph‐Nygell ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Oral Mucositis ◽  
Hematopoietic Stem ◽  
Severe Oral Mucositis

scholarly journals Vitamin D Deficiency and Oral Mucositis in Hematopoietic Stem Cell Transplantation: A Cross-Sectional Observation

2019 ◽  
Author(s):  
Kosar Raoufinejad ◽  
Shahrzad Pezeshki ◽  
Bahram Chahardouli ◽  
Molouk Hadjibabaie ◽  
Zahra Jahangard-Rafsanjani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Hospital Stay ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Oral Mucositis ◽  
World Health ◽  
Hematopoietic Stem

Backgrounds: One of the most frequent complications of high-dose chemotherapy regimen before hematopoietic stem cell transplantation (HSCT) is oral mucositis (OM). Vitamin D (VD) has well-known immunoregulatory, anti-inflammatory, and antioxidant properties.This study aimed to evaluate the association of pre-HSCT VD levels with OM as well as neutrophil and platelet engraftments in patients with multiple myeloma, Hodgkin’s and non-Hodgkin’s lymphoma after autologous HSCT. Methods: A sample of 71 patients was enrolled after obtaining informed consent. Serum samples were collected in the morning prior to the administration of conditioning regimen to measure the 25-OH-D. OM was examined daily during hospital stay. The World Health Organization (WHO) scale was used for scoring the OM. Absolute neutrophil count and platelet count were determined daily from transplantation until engraftment. Results: Patients aged 18-65 years. Mean length of hospital stay was 15.8±5.7 days. OM was detected in 44/71 (62.0%) of patients. Mean time to the engraftment of neutrophils and platelets were 11.8±4.0 and 17.2±7.3 days, respectively. Mean level of 25-OH-D was 17.5±14.0 ng/ml. VD deficiency (<20 ng/ml) was diagnosed in 51/71 (71.8%) of patients. No association between the 25-OH-D levels and incidence of OM (P=0.69) or OM grade 3-4 (P=0.46) was found. No significant correlations were detected between the 25-OH-D and engraftment time of neutrophils (P=0.46) or platelets (P=0.17). Conclusions: The prevalence of VD deficiency was high among adult HSCT patients at the time of transplantation. No association was found between the pre-HSCT VD level and OM or engraftment time.

scholarly journals Current approaches in oral mucositis prevention, care and treatment in hematopoietic stem cell transplantation: Literature reviewHematopoetik kök hücre naklinde oral mukozitin önlemesi, bakımı ve tedavisinde güncel yaklaşımlar: Literatür incelemesi

2016 ◽  
Vol 13 (3) ◽  
pp. 5721
Author(s):  
Ebru Baysal ◽  
Dilek Sarı
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Oral Mucositis ◽  
Oral Care ◽  
Hematopoietic Stem ◽  
Transplant Patients ◽  
Prevention And Treatment

Oral mucositis is important inflammatory complications affecting the esophagus, oropharyngeal mucosa and gastrointestinal tract in cancer patients receiving chemotherapy and radiotherapy. Oral mucositis’ incidence is depending on the conditioning regimen, type of disease and the applied transmission procedure. It’s incidence is 35-75% in autologous transplant patients and 75-100% in allogeneic transplant patients. The aim of this review, examine the results of the researches for prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation. The population of this study is consisted of 1094 articles from accessed by searching with "hematopoietic stem cell transplantation", "oral mucositis" and "oral care" key words on “Medline”, "Ebscohost", "PubMed", "Web of Science" and "Google Scholar" databases by in dates between June-August 2016. In this review, the articles were selected as full text and they were published in English and Turkish languages in the last decade. The sample of the review have occurred total 26 studies of these articles that meet the research’s criteria. In researches were included in the review, palifermin (6 articles) and prophylactic laser therapy (4 articles) was determined the most widely used methods for prevention and treatment of oral mucositis. Most of the research has been conducted in adult patients with Allogeneic Stem Cell Transplantation. The methods used in the 24 researchs have been determined to be effective in the prevention and treatment of oral mucositis. The majority of the methods used in researchs, especially palifermin and prophylactic laser, have been found to be effective in prevention and treatment of oral mucositis, however there is no standardized oral care protocol for hematopoietic stem cell transplantation patients. ÖzetOral mukozit kemoterapi ve radyoterapi alan kanser hastalarında orofarengeal mukoza, özefagus ve gastrointestinal sistemi etkileyen önemli inflamatuar bir komplikasyondur. Hastalığın türüne, uygulanan hazırlık rejimi ve nakil prosedürüne bağlı olarak oral mukozit görülme oranı otolog nakil hastalarında %35-75, allojenik nakil hastalarında ise %75-100’dür. Bu derleme hematopoetik kök hücre nakli yapılan hastalarda oral mukozitin önlenmesine ve tedavisine yönelik yapılan çalışmaların sonuçlarını incelemek amacıyla planlanmıştır. Çalışmanın evrenini Haziran-Ağustos 2016 tarihlerinde “hematopoetic stem cell trasplantation”, “oral mucositis” ve “oral care” anahtar kelimeleriyle “Medline”, “Ebscohost”, “Pubmed”, “Web of Science” ve “Google Scholar” veri tabanları taranarak ulaşılan 1094 makale oluşturmuştur. İncelemede son on yılda yayınlanmış, yayın dili Türkçe ve İngilizce olan ve tam metni bulunan makaleler seçilmiştir. Araştırma kriterlerini karşılayan 26 makale derlemenin örneklemini oluşturmuştur. Derlemeye dahil edilen araştırmalarda oral mukozitin önlenmesi ve tedavisi için en fazla kullanılan yöntemlerin palifermin uygulaması (6 makale) ve profilaktik lazer tedavisi (4 makale) olduğu saptanmıştır. Araştırmaların büyük bir kısmı Allojenik Kök Hücre Nakli yapılan yetişkin hastalarda yapılmıştır. Derleme kapsamındaki 24 araştırmada kullanılan yöntemlerin oral mukozitin önlenmesi ve tedavisinde etkili olduğu belirlenmiştir. Araştırmalarda kullanılan yöntemlerin çoğunluğunun özellikle palifermin ve profilaktik lazer tedavisinin oral mukozitin önlenmesinde ve tedavisinde etkili olduğu fakat hematopoetik kök hücre nakli hastaları için standart ağız bakım protokolü bulunmadığı saptanmıştır.

Risk factors and implications of oral mucositis in recipients of allogeneic hematopoietic stem cell transplantation

2019 ◽  
Vol 103 (4) ◽  
pp. 402-409 ◽  
Author(s):  
Roni Shouval ◽  
Elizaveta Kouniavski ◽  
Joshua Fein ◽  
Ivetta Danylesko ◽  
Noga Shem‐Tov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Oral Mucositis ◽  
Hematopoietic Stem
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