Molecular matching for patients with haematological diseases expressing altered RHD ‐ RHCE genotypes

Vox Sanguinis ◽  
2019 ◽  
Vol 114 (6) ◽  
pp. 605-615 ◽  
Author(s):  
Bruno Ribeiro Cruz ◽  
Thamy Caroline Silva ◽  
Bianca Castro ◽  
Akemi Kuroda Chiba ◽  
Elyse Moritz ◽  
...  
Keyword(s):  
Molecular Matching

Risk evaluation of duodenoscope-associated infections in the Netherlands calls for a heightened awareness of device-related infections: a systematic review

Endoscopy ◽  
2021 ◽  
Author(s):  
Judith A. Kwakman ◽  
Nicole S. Erler ◽  
Margreet C. Vos ◽  
Marco J. Bruno
Keyword(s):  
The Netherlands ◽  
Multidrug Resistant ◽  
Healthcare Personnel ◽  
Endoscopic Retrograde ◽  
Minimum Risk ◽  
Actual Risk ◽  
Molecular Matching ◽  
Estimated Risk ◽  
Technical Solutions ◽  
Risk Ratios

Abstract Background The risk of exogenous infections from endoscopic procedures is often cited as almost negligible (1 infection in 1.8 million procedures); however, this risk is based on older literature and does not seem to match the number of infectious outbreaks due to contaminated duodenoscopes reported after endoscopic retrograde cholangiopancreatography (ERCP). Using Dutch data, we aimed to estimate the minimum risk of duodenoscope-associated infection (DAI) and colonization (DAC) in patients undergoing ERCP. Methods A systematic literature search identified all DAI outbreaks in the Netherlands reported between 2008 and 2019. Included cases were confirmed by molecular matching of patient and duodenoscope cultures. Risk ratios were calculated based on the total number of ERCPs performed during the study period. Results Three outbreaks were reported and published between 2008 and 2018, including 21 confirmed DAI cases and 52 confirmed DAC cases. The estimated number of ERCPs performed during the same period was 181 209–227 006. The calculated minimum estimated DAI risk was approximately 0.01 % and the minimum estimated DAC risk was 0.023 %–0.029 %. Conclusions The estimated risk of DAI in Dutch ERCP practice was at least 180 times higher than previously published risk estimates. The actual risk is likely to be (much) higher due to underreporting of infections caused by multidrug-resistant organisms and sensitive bacteria. Greater awareness by healthcare personnel involved in endoscopy and endoscope cleaning is required, as well as innovative technical solutions to contain and ultimately eliminate DAIs.

scholarly journals Characterization of Human Knee and Chin Adipose-Derived Stromal Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Magali Kouidhi ◽  
Phi Villageois ◽  
Carine M. Mounier ◽  
Corinne Ménigot ◽  
Yves Rival ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Expression Profiles ◽  
Donor Site ◽  
Subcutaneous Fat ◽  
Gene Expression Profiles ◽  
Fat Grafting ◽  
Human Knee ◽  
Fat Depots ◽  
Adipose Derived Stromal Cells ◽  
Molecular Matching

Animal study findings have revealed that individual fat depots are not functionally equivalent and have different embryonic origins depending on the anatomic location. Mouse bone regeneration studies have also shown that it is essential to match theHoxcode of transplanted cells and host tissues to achieve correct repair. However, subcutaneous fat depots from any donor site are often used in autologous fat grafting. Our study was thus carried out to determine the embryonic origins of human facial (chin) and limb (knee) fat depots and whether they had similar features and molecular matching patterns. Paired chin and knee fat depots were harvested from 11 subjects and gene expression profiles were determined by DNA microarray analyses. Adipose-derived stromal cells (ASCs) from both sites were isolated and analyzed for their capacity to proliferate, form clones, and differentiate. Chin and knee fat depots expressed a differentHOXcode and could have different embryonic origins. ASCs displayed a different phenotype, with chin-ASCs having the potential to differentiate into brown-like adipocytes, whereas knee-ASCs differentiated into white adipocytes. These results highlighted different features for these two fat sites and indicated that donor site selection might be an important factor to be considered when applying adipose tissue in cell-based therapies.

scholarly journals Molecular matching of red blood cells is superior to serological matching in sickle cell disease patients

2013 ◽  
Vol 35 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Daiane Cobianchi da Costa ◽  
Jordão Pellegrino Jr ◽  
Gláucia Andréia Soares Guelsin ◽  
Karina Antero Rosa Ribeiro ◽  
Simone Cristina Olenscki Gilli ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Cell Disease ◽  
Molecular Matching

scholarly journals Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes

2021 ◽  
Author(s):  
Suzanne Bezstarosti ◽  
Cynthia S.M. Kramer ◽  
Frans H.J. Claas ◽  
Johan W. de Fijter ◽  
Marlies E.J. Reinders ◽  
...  
Keyword(s):  
Molecular Matching

Abstract CT053: High rates of personalized molecular matching are achievable in a precision oncology navigation trial: the I-PREDICT study

2017 ◽  
Author(s):  
Jason K. Sicklick ◽  
Brian Leyland-Jones ◽  
Shumei Kato ◽  
Casey Williams ◽  
Pradip De ◽  
...  
Keyword(s):  
Precision Oncology ◽  
Molecular Matching ◽  
Predict Study
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