Effect of a liberal versus a restrictive pre‐donation blood pressure policy on whole‐blood donor adverse reactions

Vox Sanguinis ◽  
2019 ◽  
Vol 114 (4) ◽  
pp. 317-324
Author(s):  
Ugo Salvadori ◽  
Marco Sandri ◽  
Roberto Cemin ◽  
Ahmad Al‐Khaffaf ◽  
Massimo Daves ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Donor ◽  
Whole Blood ◽  
Adverse Reactions

The effect of pre-donation hypotension on whole blood donor adverse reactions: a systematic review

2014 ◽  
Vol 8 (6) ◽  
pp. 429-436 ◽  
Author(s):  
Nele S. Pauwels ◽  
Leila Cusack ◽  
Emmy De Buck ◽  
Veerle Compernolle ◽  
Philippe Vandekerckhove
Keyword(s):  
Systematic Review ◽  
Blood Donor ◽  
Whole Blood ◽  
Adverse Reactions

International Forum on Mitigation Strategies to Prevent Faint and Pre‐faint Adverse Reactions in Whole Blood Donors: Responses

Vox Sanguinis ◽  
2021 ◽  
Vol 116 (3) ◽  
Author(s):  
Mindy Goldman ◽  
Mary Townsend ◽  
Karin Magnussen ◽  
Miquel Lozano ◽  
Lise Sofie H. Nissen‐Meyer ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Adverse Reactions ◽  
Mitigation Strategies ◽  
International Forum

scholarly journals Blood Donation-Related Adverse Reactions: Results of an Online Survey among Donors in Germany (2018)

2021 ◽  
pp. 1-11
Author(s):  
Stefano Orru’ ◽  
Kay Poetzsch ◽  
Marcus Hoffelner ◽  
Margarethe Heiden ◽  
Markus B. Funk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Whole Blood ◽  
Online Survey ◽  
Adverse Reactions ◽  
Blood Donation ◽  
Age Groups ◽  
Female Gender ◽  
Online Questionnaire ◽  
Logistic Analysis ◽  
German Legislation

<b><i>Introduction:</i></b> According to German legislation, reports of suspected serious adverse reactions (AR) associated with the donation of blood and its components are continuously being evaluated by the Paul-Ehrlich-Institut. This survey aimed at providing a more complete picture of the AR associated with the donation of blood and blood components. <b><i>Materials and Methods:</i></b> Eligible donors had the opportunity to anonymously report all AR occurring during or after their last donation by completing an online questionnaire. Reported AR were classified according to the Standard for Surveillance of Complications Related to Blood Donation. Donors’ self-assessment of AR seriousness was compared with the official severity classification as laid down by German legislation. Besides a descriptive statistical analysis, a multiple logistic analysis was performed to identify risk factors for AR. <b><i>Results:</i></b> A total of 8,138 data records were evaluated. Slightly more males (57.9%) participated in the survey and, except for donors aged ≥60 years, all age groups were equally represented. The majority of participants were whole blood donors (85.4%), repeat donors (97.2%), and stayed under observation in the blood establishment (BE) for more than 5 min (63.1%) after donation. Most participants did not report any reaction (72.5%), whereas 2,237 reported at least one AR (27.5%), 475 of whom underwent apheresis and 1,762 donated whole blood. Most AR occurred after leaving the BE (64.4%). Only a minority of participants required medical treatment (5.1%) or assessed the experienced AR as serious (3.9%). The most frequently reported donor AR were haematoma and other local reactions (57.6%). Vasovagal reactions without and with loss of consciousness were developed in 17 and 2% of the participants, respectively, whilst 7.6% experienced citrate reactions. New AR (i.e., allergic reactions and symptoms associated with iron deficiency) were reported as well. The occurrence of AR was linked to risk factors (i.e., female gender, young age, first-time donation, and thrombocytapheresis). <b><i>Discussion:</i></b> This survey yielded a more comprehensive AR spectrum, revealed a prolonged time to symptom onset, and identified risk factors for AR. This novel information could be implemented in an amended informed consent addressing common and rare AR.

scholarly journals Retrospective analysis of the most common cause of rejection of donors for blood donation

2021 ◽  
Vol 8 (3) ◽  
pp. 444
Author(s):  
Garima Vijayvergiya ◽  
Parag Fulzele ◽  
Naveen Vairyamoorthy
Keyword(s):  
Blood Pressure ◽  
Blood Donor ◽  
Blood Donation ◽  
Tertiary Care ◽  
Geographical Area ◽  
Rejection Rate ◽  
Developed Countries ◽  
Care Hospital ◽  
Systemic Examination ◽  
Safe Blood

Background: A significant imbalance in access to safe blood is seen between the developing and developed countries. Donor selection has a pivotal role in preventing transfusion related complications and provide safety to the recipients. In this study, we aimed to find out rate and causes of blood donor rejection in our hospital.  Methods: A retrospective study conducted in a tertiary care hospital involving both the voluntary and replacement donors during the period September 2017 to December 2018. We included all those donors who were considered unfit for blood donation. All those who came for blood donation at our hospital were asked to fill up an enrolment form for a blood donor. A general and systemic examination were done. We calculated the rejection rate, listed the reasons for donor rejection, and analyzed the data.Results: Among 150 rejected blood donors, most were males [129 (86%)], and the rest were females [21 (14%)]. The rejection rate in our study was 3.29%. We found that the rejection rate of donors was different among voluntary and replacement donors. It showed that the most common reason for the temporary rejection of blood donation was low hemoglobin level, followed by abnormal blood pressure.  Conclusions: A vast majority of donors were rejected temporarily [132 (88%)], while the rest of them were rejected permanently [18 (12%)]. Low Hb in females and abnormal blood pressure in males were the commonest causes of blood donor rejection. Many factors affect the similarities and variations between the most typical causes of blood donor rejection, such as geographical area, cultural, socio-economic, and educational factors.  

scholarly journals The Application Effect of High Quality Nursing Service in the Painless Gastroscopy Examination

2013 ◽  
Vol 2 ◽  
pp. 6
Author(s):  
Jina Guo
Keyword(s):  
Blood Pressure ◽  
Gastrointestinal Tract ◽  
Reaction Rate ◽  
Adverse Reactions ◽  
High Quality ◽  
Nursing Service ◽  
Satisfaction Rate ◽  
Low Blood Pressure ◽  
Tract Disease ◽  
Hands And Feet

<strong>Objective:</strong> To discuss the application effect of high quality nursing service in the painless gastroscopy examination. <strong>Methods:</strong> Selected 132 cases of patients with gastrointestinal tract disease admitted by my hospital from May 2012 to May 2013 as the research object, 132 cases of patients with gastrointestinal tract disease were all given painless gastroscopy examination, clinically, all of them were given high quality nursing service. Observed and recorded nursing effect. <strong>Results:</strong> Among 132 cases of patients, there were 3 cases appeared untoward effect such as choking cough, respiratory depression, abdominal pain, low blood pressure and other adverse reactions, the adverse reaction rate was 2.27% (3/132); 0 cases of hospital infection; 132 cases all had side effects of propofol (dizzy giddy, hands and feet became limp, but no case of fell down; 131 patients were satisfied with high quality nursing service, the satisfaction rate was 99.2% (131/132). <strong>Conclusion:</strong> The application effect of high quality nursing service in painless gastroscopy examination was remarkable.

scholarly journals Therapeutic effect of nifedipine combined with enalapril on elderly patients with coronary heart disease complicated with hypertension

2018 ◽  
Vol 2 (6) ◽  
Author(s):  
Xiaoye Wang
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elderly Patients ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Significant Difference ◽  
Pre Treatment ◽  
Experimental Group

【Abstract】Objective: Toanalyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.METHODS:Sixty-six elderly patients with coronary heart disease and hypertension were enrolled from December 2017 to November 2018. They were randomly divided into two groups, 33 patients in each group. Patients in the experimental group received nifedipine. In combination with enalapril, patients enrolled in the control group received nifedipine monotherapy.RESULTS:Compared with the control group, the total effective rate, Serum Nitric Oxide (Serum NO) after treatment, CRP after treatment, HCY after treatment, and blood pressure after treatment were significantly improved (P<0.05). Serum NO and treatment before treatment in the 2 groups. There was no significant difference in pre-CRP, pre-treatment HCY, pre-treatment blood pressure, and adverse reactions during treatment (P>0.05).Conclusion: Theelderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril.

CQP 201-403, a new dopamine agonist in the treatment of hyperprolactinemia

1988 ◽  
Vol 117 (4) ◽  
pp. 552-556 ◽  
Author(s):  
L. E. Hanssen ◽  
J. Brownell ◽  
J. Halse ◽  
J. Jervell ◽  
K. T. Stokke ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Orthostatic Hypotension ◽  
Dopamine Agonist ◽  
Drug Administration ◽  
Pituitary Adenomas ◽  
Adverse Reactions ◽  
Area Under The Curve ◽  
Control Group ◽  
Standing Blood Pressure

Abstract. Current drugs used for hyperprolactinemia may have severe side effects. Effects and side effects of a new propylergoline derivate (CQP 201-403 SANDOZ®) have been evaluated. Twenty-four otherwise healthy women (21–44 years) with hyperprolactinemia (35–318 μg/l) without extrasellar extension of pituitary adenomas took part in a randomized, doubleblind study. Fasting prolactin levels measured on day 7 was significantly decreased when compared with day 1 (P < 0.05) in all CQP groups, to 78% with 0.005 mg daily, to 40% with 0.015 mg daily, and to 27% with 0.025 mg CQP per day for one week. The levels in the control group did not change (96%). The area under the curve of the prolactin day curve (1–8 h after drug administration) decreased significantly (P < 0.05) at all doses when day 7 was compared with day 1, to 77% with 0.005 mg, to 51% with 0.015 mg, and to 37% with 0.025 mg CQP. No change was seen in the control group (96%). Four patients (one on 0.005 mg, one on 0.015 mg, and two on 0.025 mg) experienced orthostatic hypotension while standing blood pressure was to be measured on the first day of treatment, and they had to lie down. CQP 201-403 lowers prolactin levels in hyperprolactinemic women at all doses employed. The effect was seen after the first dose of treatment, and lasted for at least 24 h. The adverse reactions are few and tolerable, and might be less than with current bromocriptine therapy.

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