Dissecting the decline of hepatitis C in first-time donors in England and Wales

Vox Sanguinis ◽  
2018 ◽  
Vol 113 (4) ◽  
pp. 329-338 ◽  
Author(s):  
C. A. Reynolds ◽  
K. L. Davison ◽  
N. Andrews ◽  
P. Patel ◽  
A. Kitchen ◽  
...  
Keyword(s):  
Hepatitis C ◽  
England And Wales ◽  
First Time

Outlawing incitement to religious hatred—a British perspective

2006 ◽  
Vol 1 (3) ◽  
pp. 249-268 ◽  
Author(s):  
Peter Cumper
Keyword(s):  
Free Speech ◽  
Hate Speech ◽  
England And Wales ◽  
Racial Hatred ◽  
Important Measure ◽  
British Perspective ◽  
First Time

AbstractThe recent enactment of the Racial and Religious Hatred Act 2006 makes it (for the first time) unlawful to incite hatred on religious grounds in England and Wales. This legislation has however been attacked by a number of Muslims on the basis that it is too rigidly drawn, and that the scope of the offence of incitement to religious hatred is narrower than comparable legislation governing incitement to racial hatred. In critically analysing the Racial and Religious Hatred Act 2006, this article makes particular reference to the recent Islamic Council of Victoria case in Australia on religious vili cation and hate speech which, it is suggested, provides a salutary lesson to those who would seek to expand the remit of the Act. It is argued that the Racial and Religious Hatred Act is not merely a symbolically important measure, but is also a fair and workable compromise which protects faith groups from incitement to religious hatred without placing excessive curbs on free speech.

scholarly journals Emergence of high-level azithromycin resistance in Neisseria gonorrhoeae in England and Wales

2008 ◽  
Vol 13 (15) ◽  
Author(s):  
S A Chisholm ◽  
C Ison
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Sequence Type ◽  
Surveillance Programme ◽  
England And Wales ◽  
High Level ◽  
First Time ◽  
Azithromycin Resistance

The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) in England and Wales has monitored azithromycin resistance since 2001. In 2007, high-level azithromycin resistance (MICs >256 mg/L) was identified for the first time in six isolates, all of which were the same sequence type (ST 649).

Winners of the Nobel Prize in Medicine in 2020

2021 ◽  
pp. 59-63
Author(s):  
Oksana Aleksandrovna Rybachok
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nobel Prize ◽  
The Body ◽  
Coronavirus Infection ◽  
First Time ◽  
Selection Of

Despite the height of the coronavirus infection, the Nobel Prize in Medicine was awarded in Stockholm in October 2020. This event was held online for the first time and was not accompanied by the traditional honoring of the laureates. In his will, Alfred Nobel entrusted the selection of the winner in this nomination to the Karolinska Medical and Surgical University of Stockholm, and the first award in this nomination took place in 1901. Since then, this event has been held 110 times, and 216 scientists have become laureates of the prize in the field of physiology and medicine, since the nominees are often not just one, but a group of researchers. This happened in 2020 - for research in the field of studying the hepatitis C virus, three scientists received the most prestigious award: the British Michael Houghton and the Americans Harvey Alter and Charles Rice. Due to the results of the research, which these three people conducted separately from each other, for the first time it became possible to completely eliminate the virus from the body.

Heart Transplantation in a Fontan Patient Using a Hepatitis C-Positive Donor

2019 ◽  
Vol 10 (4) ◽  
pp. 504-504
Author(s):  
Jonathan N. Menachem ◽  
David P. Bichell ◽  
Benjamin Frischhertz ◽  
Ashish S. Shah ◽  
Kelly Schlendorf
Keyword(s):  
Hepatitis C ◽  
Heart Transplantation ◽  
Congenital Heart ◽  
Donor Heart ◽  
Fontan Patient ◽  
Extracardiac Conduit ◽  
History Of ◽  
Pulmonary Artery Reconstruction ◽  
Artery Reconstruction ◽  
First Time

A 38-year-old female with tricuspid atresia and normally related great arteries, initially palliated with Björk modified Fontan, and ultimately converted to extracardiac conduit Fontan, with a history of ventricular tachycardia and hepatitis C virus (HCV) treated with sofosbuvir/ledipasvir, was referred to our center for consideration of combined heart and liver transplantation. The patient’s blood group was O with panel reactive antibodies of 52%. She consented to consideration of HCV-positive donors. Fifteen days later, an HCV-positive donor was identified, and she underwent heart transplantation with pulmonary artery reconstruction performed jointly by adult and pediatric transplant surgeons. To our knowledge, this the first time an HCV-positive donor heart has been to transplant an adult with congenital heart disease.

scholarly journals Occupation Mortalities

1911 ◽  
Vol 5 ◽  
pp. 1-86
Author(s):  
James Craufurd Dunlop
Keyword(s):  
England And Wales ◽  
Registrar General ◽  
The Subject ◽  
First Time

Mr. President,—It is in response to your invitation that I venture to submit to this Faculty a paper on the Influence of Occupation on Mortality. I have no fresh statistical observations to lay before you, but the task I have set myself is to elaborate the observations set out in the Supplement to the Registrar-General of England and Wales' Sixty-fifth Report, part II., a report which was published early this year. That report may rightly be described as the most important contribution to our knowledge of the subject which has yet been published, and it is thanks to the excellent tabulation of facts in it that I am able to deal further with them.Before asking your attention to the subject proper of my paper, an examination of the results of the recent English study, I desire briefly to describe previous statistical observations on the subject, to indicate to you some of the difficulties and limitations in drawing satisfactory conclusions from these studies, and to explain the methods which have previously been used to overcome these difficulties, and methods which I now use for the first time.

Medical abortions more common than surgery for first time in 2014 in England and Wales

BMJ ◽  
2015 ◽  
Vol 350 (jun09 13) ◽  
pp. h3177-h3177 ◽  
Author(s):  
Z. Kmietowicz
Keyword(s):  
England And Wales ◽  
First Time

scholarly journals The Correlation between miR-122 and Lipoprotein Lipase Expression in Chronic Hepatitis C Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Malgorzata Sidorkiewicz ◽  
Martyna Grek-Kowalinska ◽  
Anna Piekarska
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Lipoprotein Metabolism ◽  
Hcv Rna ◽  
Chronic Hcv Infection ◽  
Liver Biopsies ◽  
Chronic Hcv ◽  
First Time ◽  
Chronic Hepatitis C Patients

Chronic HCV infection is strictly associated with host lipid/lipoprotein metabolism disorders. The study aimed to analyze the relationship between viral load, lipid profile, IFNγ, and the expression of miR-122 and LPL in the liver and PBMCs. Sera, PBMCs, and matching liver biopsies from 17 chronic hepatitis C patients were enrolled in this study. Collected data shows that liver (not PBMCs) miR-122 expression is positively correlated with HCV RNA load and IFNγ and reversely with LPL expression in CHC patients. Presented, for the first time, in this study, the reverse correlation of miR-122 and LPL expression in liver; miR-122 and LPL seem to be important factors of CHC infection.

scholarly journals Expression of the Novel Hepatitis C Virus Core+1/ARF Protein in the Context of JFH1-Based Replicons

2015 ◽  
Vol 89 (9) ◽  
pp. 5164-5170 ◽  
Author(s):  
Ioly Kotta-Loizou ◽  
Ioannis Karakasiliotis ◽  
Niki Vassilaki ◽  
Panagiotis Sakellariou ◽  
Ralf Bartenschlager ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Gene ◽  
Open Reading Frame ◽  
The Novel ◽  
Reading Frame ◽  
The Core ◽  
Virus Core ◽  
First Time ◽  
Arf Protein

Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.

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