Assessment of tear film osmolarity using the IPen ® Vet osmometer in Pug and Shih‐Tzu dogs with and without keratoconjunctivitis sicca

2021 ◽  
Author(s):  
Fábio L. da C. Brito ◽  
Jéssica N. Voitena ◽  
Tatiane O. C. Marinho ◽  
Bret A. Moore ◽  
Fabiano Montiani‐Ferreira
Keyword(s):  
Keratoconjunctivitis Sicca ◽  
Tear Film

scholarly journals Oral mucosa transplantation may improve tear film osmolarity in dogs with keratoconjunctivitis sicca - a preliminary study

2021 ◽  
Vol 73 (6) ◽  
pp. 1278-1286
Author(s):  
F.L.C. Brito ◽  
A. Kuner ◽  
J.N. Voitena ◽  
T.O.C. Marinho
Keyword(s):  
Oral Mucosa ◽  
Repeated Measures ◽  
Keratoconjunctivitis Sicca ◽  
Tear Film ◽  
Normality Test ◽  
Group I ◽  
Schirmer Tear Test ◽  
Before And After ◽  
The Right ◽  
Surgical Treatments

ABSTRACT The objective of this study was to evaluate the use of cyclosporine 1% alone or associated with oral mucosa transplantation (OMT) in dogs with dry keratoconjunctivitis (KCS). Schirmer Tear Test (STT-1) and Tear Film Osmolarity (TFO) were measured in both eyes of 30 adult dogs (before and 45 days after treatment. The animals were divided into three groups (10 dogs for group): control (normal dogs), group I (GI, treated with 1% cyclosporine alone), and group II (GII, treated with 1% cyclosporine and OMT). All STT-1 and TFO values were subjected to the Shapiro-Wilk normality test, and all were normally distributed. STT-1 and TFO values before and after treatment were subjected to the T-Student Test. The STT‐1 and TFO values of the right eye were subjected to Repeated Measures ANOVA followed by a Tukey Test for comparison between groups I and II. Means with a value of p≤0.05 were considered significant. There was a decreased osmolarity in both groups after treatment. Mean osmolarity in GII (322.60±16.56 mOsm/L) was significantly lower than GI (336.40±5.66 mOsm/L). The OMT associated with cyclosporine 1% improved the osmolarity of the tear film in dogs with KCS with a seeming synergism between the clinical and surgical treatments.

EFFECTS OF AUTOLOGOUS SERUM EYE DROPS FOR TREATMENT OF KERATOCONJUNCTIVITIS SICCA IN DOGS

2018 ◽  
Vol 44 (03) ◽  
pp. 111-117
Author(s):  
Han-Syuan Lin ◽  
Shiun-Long Lin ◽  
Feng-Jen Chang
Keyword(s):  
Clinical Symptoms ◽  
Keratoconjunctivitis Sicca ◽  
Tear Film ◽  
Autologous Serum ◽  
Eye Drops ◽  
Film Stability ◽  
Staining Score ◽  
Schirmer Tear Test ◽  
The Status ◽  
Ocular Surface Health

In humans, autologous serum (AS) eye drops has been applied for the treatment of refractory keratoconjunctivitis sicca (KCS) for several decades. However, there are few researches to investigate the AS eye drops in dogs with KCS. The objective of this study was to evaluate the effects of AS eye drops on treatment of KCS in dogs. Eighteen eyes of ten client-owned dogs with refractory KCS were used in this study. Schirmer tear test (STT), tear film breakup time (TBUT), fluorescein (FL) staining score, and Rose Bengal (RB) staining score were used to measure the status of cornea prospectively at baseline and 1–3 months after treatment. Additionally, the results were further stratified by their STT value, sex, and age. The results indicated that the mean TBUT, FL staining score, and RB staining score were significantly improved after treatment except STT. In 18 eyes, 77.8% eyes had decreased mucopurulent ocular discharge and 38.9% eyes got wet. Besides, both TBUT and RB staining score were significantly improved in a subgroup of dogs with age less than 9 years old. As far as we know, this study is the first trial to determine the efficacy and safety of 20% AS eye drops for cKCS. In conclusion, AS eye drops seemed to be effective and safe for dogs with KCS, and it could improve tear film stability, ocular surface health, and subjective clinical symptoms, especially in dogs younger than 9 years old.

Identification of 9-O-acetyl-N-acetylneuraminic acid in normal canine pre-ocular tear film secreted mucins and its depletion in Keratoconjunctivitis sicca

2005 ◽  
Vol 22 (7-9) ◽  
pp. 409-416 ◽  
Author(s):  
A. P. Corfield ◽  
S. R. Donapaty ◽  
S. D. Carrington ◽  
S. J. Hicks ◽  
R. Schauer ◽  
...  
Keyword(s):  
Keratoconjunctivitis Sicca ◽  
Tear Film ◽  
Acetylneuraminic Acid

Cataract Surgery Destabilises Temporary the Tear Film of the Ocular Surface

2020 ◽  
Author(s):  
Le Xuan Cung ◽  
Nguyen Thi Thanh Nga ◽  
Duong Mai Nga ◽  
Nguyen Xuan Hiep ◽  
Duy Thoai Pham
Keyword(s):  
Cataract Surgery ◽  
Ocular Surface ◽  
Keratoconjunctivitis Sicca ◽  
Tear Film ◽  
Vital Staining ◽  
Ocular Surface Disease Index ◽  
Corneal Incision ◽  
Meniscus Height ◽  
The Third ◽  
Clear Corneal Incision

Abstract Background Symptoms due to dry eye in the form of keratoconjunctivitis sicca (KCS) are often seen after cataract surgery. We investigated the influence of cataract surgery on tear film stability on the ocular surface. Material and Methods 60 eyes of 60 patients who underwent cataract surgery were included in a prospective study in 2017 at the Eye Hospital in Hanoi (Vietnam National Institute of Ophthalmology). The mean age of the patients was 65 ± 10 years. The phacoemulsification was performed under topical anaesthesia by a clear corneal incision and implantation of a foldable IOL. The parameters for the evaluation of the change of the tear film included subjective patient data using the Ocular Surface Disease Index questionnaire (OSDI), findings of the Schirmer I test, the tear break-up time (TBUT) as well as the tear meniscus height (TMH) measured noninvasively with the Keratograph 5M (Oculus). In addition, conjunctival and corneal changes were examined after vital staining with fluorescein for the cornea and rose bengal for the conjunctiva. Data were collected preoperatively, at 1 week, 1 month and 3 months postoperatively. According to DEWS, the disease is classified into 4 groups: mild, moderate, severe and very severe. Results One week after surgery, the total score according to OSDI was significantly increased with a total value of 14.4 ± 4.2 (p = 0.001). Schirmer I was 15.8 ± 4.3 mm preoperatively and decreased significantly in the first postoperative week (p = 0.001), before reaching the preoperative level again after three months. TBUT was 12.6 ± 1.5 s preoperatively, decreased significantly to 9.7 ± 1.5 s during the first postoperative week, and normalized to 12.4 ± 1.3 s by the end of the third month. The meniscus height was 0.245 ± 0.055 mm preoperatively, significantly lowered to 0.229 ± 0.057 mm in the first postoperative period and nearly normalised by the third postoperative month to 0.241 ± 0.051 mm. In the first postoperative week, the rate of mild KCS was observed in 30% of patients. At one month, this decreased to 10% and at three months was no longer demonstrable in any patient. Conclusion One of three patients experienced mild KCS after cataract surgery. The symptoms lasted up to three months. This should be taken into account preoperatively and appropriate therapy should be planned.

scholarly journals Assessment of tear film osmolarity using the TearLab™ osmometer in normal dogs and dogs with keratoconjunctivitis sicca

2016 ◽  
Vol 20 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Lionel Sebbag ◽  
Shin Ae Park ◽  
Philip H. Kass ◽  
David J. Maggs ◽  
Mayssa Attar ◽  
...  
Keyword(s):  
Keratoconjunctivitis Sicca ◽  
Tear Film

Polarized light biomicroscopic observations on the pre-corneal tear film. 2. Keratoconjunctivitis sicca in the dog

1987 ◽  
Vol 28 (8) ◽  
pp. 671-679 ◽  
Author(s):  
S. D. CARRINGTON ◽  
P. G. C. BEDFORD ◽  
J.-P. GUILLON ◽  
E. G. WOODWARD
Keyword(s):  
Keratoconjunctivitis Sicca ◽  
Polarized Light ◽  
Tear Film

scholarly journals Qualitative and quantitative tear film abnormalities in dogs

2008 ◽  
Vol 38 (2) ◽  
pp. 568-575 ◽  
Author(s):  
Alexandre Pinto Ribeiro ◽  
Fabio Luiz da Cunha Brito ◽  
Bianca da Costa Martins ◽  
Fabrício Mamede ◽  
José Luiz Laus
Keyword(s):  
Veterinary Medicine ◽  
Clinical Practice ◽  
T Lymphocytes ◽  
Keratoconjunctivitis Sicca ◽  
Tear Film ◽  
Daily Clinical Practice ◽  
Qualitative And Quantitative ◽  
Therapeutic Modalities ◽  
Schirmer Tear Test ◽  
Ocular Disorders

Tear film disorders in dogs can be classified into quantitative or qualitative abnormalities, or both, and are commonly observed in daily clinical practice. Inadequate production of one or more tear film components can lead to variable degrees of ocular disorders, called keratoconjunctivitis sicca. Keratoconjunctivitis sicca in dogs has several causes, but in most cases the disease is idiopathic, with T lymphocytes playing a role. In veterinary medicine, the diagnosis is made based on the results of the Schirmer tear test. In this article, we review aspects related to the etiopathogenesis and diagnosis of keratoconjunctivitis sicca in dogs and discuss new therapeutic modalities for this disease.

scholarly journals Microalterations in the third eyelid gland of dogs with keratoconjunctivits sicca secondary to distemper

2007 ◽  
Vol 59 (2) ◽  
pp. 340-344
Author(s):  
F.L.C. Brito ◽  
V.A. Silva Júnior ◽  
F.C.L. Maia ◽  
J.R. Pereira Junior ◽  
J.L. Laus
Keyword(s):  
Plasma Cells ◽  
Keratoconjunctivitis Sicca ◽  
Tear Film ◽  
Compensatory Hypertrophy ◽  
Polymorphonuclear Cells ◽  
Schirmer Tear Test ◽  
Aqueous Component ◽  
End Stage ◽  
Gland Atrophy ◽  
Hematoxylin Eosin

Keratoconjunctivitis sicca is characterized by qualitative or quantitative abnormalities in the aqueous component of the tear film and is frequent in dogs with distemper. Twenty-eight third eyelid glands of end-stage dogs that died from distemper were analyzed by light microscopy. Keratoconjunctivitis sicca was diagnosed based on ophthalmic findings regarding alterations in the ocular surface and by the Schirmer tear test. The excised glands were fixed in 10% buffered formalin and processed for embedding in paraffin. The blocks were cut into 4µm sections and the sections were stained with hematoxylin-eosin and Masson's trichrome. Analysis revealed tubuloacinar gland atrophy, thickening of connective tissue, and mild to intense inflammatory exudation mainly characterized by the presence of plasma cells and histiocytes and by compensatory hypertrophy of some glands. The glandular lumen was hypertrophied and contained shedded epithelial cells, polymorphonuclear cells and red blood cells, in addition to mucus.

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