Development of retinal bullae in dogs with progressive retinal atrophy

2021 ◽  
Author(s):  
Luis Felipe L. P. Marinho ◽  
Laurence M. Occelli ◽  
Mariza Bortolini ◽  
Kelian Sun ◽  
Paige A. Winkler ◽  
...  
Keyword(s):  
Progressive Retinal Atrophy ◽  
Retinal Atrophy

scholarly journals A CNGB1 Frameshift Mutation in Papillon and Phalène Dogs with Progressive Retinal Atrophy

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72122 ◽  
Author(s):  
Saija J. Ahonen ◽  
Meharji Arumilli ◽  
Hannes Lohi
Keyword(s):  
Frameshift Mutation ◽  
Progressive Retinal Atrophy ◽  
Retinal Atrophy

scholarly journals A novel mutation in TTC8 is associated with progressive retinal atrophy in the golden retriever

2014 ◽  
Vol 1 (1) ◽  
pp. 4 ◽  
Author(s):  
Louise M Downs ◽  
Berit Wallin-Håkansson ◽  
Tomas Bergström ◽  
Cathryn S Mellersh
Keyword(s):  
Novel Mutation ◽  
Golden Retriever ◽  
Progressive Retinal Atrophy ◽  
Retinal Atrophy

scholarly journals Allele Frequency of the C.5G>A Mutation in the PRCD Gene Responsible for Progressive Retinal Atrophy in English Cocker Spaniel Dogs

Animals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 844 ◽  
Author(s):  
Larissa R. Andrade ◽  
Amanda M. Caceres ◽  
Anelize S. Trecenti ◽  
Claudia Valeria S. Brandão ◽  
Micaella G. Gandolfi ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Genetic Disease ◽  
Mutation Frequency ◽  
Progressive Retinal Atrophy ◽  
Cocker Spaniel ◽  
High Mutation Frequency ◽  
Retinal Atrophy ◽  
History Of ◽  
Eye Examination ◽  
Mutation Region

Progressive retinal atrophy (PRA) due to the c.5G>A mutation in the progressive rod–cone degeneration (PRCD) gene is an important genetic disease in English cocker spaniel (ECS) dogs. Because the prevalence of this disease has not been verified in Brazil, this study aimed to evaluate the allele frequency of the c.5G>A mutation in the PRCD gene. Purified DNA from 220 ECS dogs was used for genotyping, of which 131 were registered from 18 different kennels and 89 were unregistered. A clinical eye examination was performed in 28 of the genotyped animals; 10 were homozygous mutants. DNA fragments containing the mutation region were amplified by PCR and subjected to direct genomic sequencing. The prcd-PRA allele frequency was 25.5%. Among the registered dogs, the allele frequency was 14.9%; among the dogs with no history of registration, the allele frequency was 41%. Visual impairment was observed in 80% (8/10) of the homozygous mutant animals that underwent clinical eye examination. The high mutation frequency found in this study emphasizes the importance of genotyping ECSs as an early diagnostic test, especially as part of an informed breeding program, to avoid clinical cases of PRA.

scholarly journals Clinical and Electroretinographic Findings of Progressive Retinal Atrophy in Miniature Schnauzer Dogs of South Korea

2013 ◽  
Vol 75 (10) ◽  
pp. 1303-1308 ◽  
Author(s):  
Man Bok JEONG ◽  
Shin Ae PARK ◽  
Se Eun KIM ◽  
Young Woo PARK ◽  
Kristina NARFSTR^|^Ouml;M ◽  
...  
Keyword(s):  
South Korea ◽  
Progressive Retinal Atrophy ◽  
Retinal Atrophy

Progressive retinal atrophy in the Abyssinian cat: an update

1983 ◽  
Vol 112 (22) ◽  
pp. 525-526 ◽  
Author(s):  
L. Narfstrom ◽  
S. Nilsson
Keyword(s):  
Progressive Retinal Atrophy ◽  
Retinal Atrophy
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