Type III hypersensitivity reaction with immune complex deposition in 2 critically ill dogs administered human serum albumin

2013 ◽  
Vol 23 (6) ◽  
pp. 598-604 ◽  
Author(s):  
Cassandra Powell ◽  
Lisa Thompson ◽  
Robert J. Murtaugh
Keyword(s):  
Human Serum Albumin ◽  
Hypersensitivity Reaction ◽  
Serum Albumin ◽  
Human Serum ◽  
Critically Ill ◽  
Immune Complex ◽  
Type Iii ◽  
Immune Complex Deposition ◽  
Complex Deposition

scholarly journals Estimation of Group B Streptococcus Type III Polysaccharide-Specific Antibody Concentrations in Human Sera Is Antigen Dependent

1998 ◽  
Vol 66 (12) ◽  
pp. 5848-5853 ◽  
Author(s):  
Reva Bhushan ◽  
Bascom F. Anthony ◽  
Carl E. Frasch
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Conjugate Vaccine ◽  
Group B Streptococcus ◽  
Antigenic Specificity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type Iii ◽  
Human Sera ◽  
Group B

ABSTRACT The presence of immunoglobulin G (IgG) antibodies against group B streptococcus (GBS) type III polysaccharide (PS) has been correlated with protection against GBS disease. The GBS type III PS is structurally similar to the pneumococcal type 14 PS, differing only in the presence of sialic acid residues. Four different preparations of GBS type III PS were evaluated for their specificity in enzyme-linked immunosorbent assay (ELISA): free PS, free PS mixed with methylated human serum albumin (mHSA), PS conjugated to biotin and PS conjugated to human serum albumin. Three groups of human sera were used to evaluate these PS preparations: sera from recipients of a GBS PS vaccine, sera from women receiving a GBS type III PS-tetanus toxoid conjugate vaccine, and sera from nonimmunized healthy women of childbearing age. Estimated antibody concentrations were different depending on the PS preparation used. Using any of the four preparations, we were able to measure ≤0.05 μg of IgG antibody to the GBS type III PS per ml. The specificity of the assay was determined by competitive inhibition with homologous and heterologous PS. The pneumococcal type 14 PS did not inhibit binding of antibody to the native GBS type III PS in sera from adults receiving the GBS PS vaccine or in sera from nonimmunized adults (except serum G9). The pneumococcal type 14 PS inhibited 50% in sera from recipients of GBS type III conjugate vaccine and in serum G9 when GBS type III PS conjugated to biotin or to HSA was used as antigen in ELISA. These data show that free GBS type III PS or PS mixed with mHSA is a sensitive and specific antigen for ELISA and that conjugation can alter the antigenic specificity of a PS.

scholarly journals Expert consensus on the use of human serum albumin in critically ill patients

2021 ◽  
Vol 134 (14) ◽  
pp. 1639-1654
Author(s):  
Yue-Tian Yu ◽  
Jiao Liu ◽  
Bo Hu ◽  
Rui-Lan Wang ◽  
Xiang-Hong Yang ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Expert Consensus

Immediate hypersensitivity reaction to human serum albumin in a child undergoing plasmapheresis

Transfusion ◽  
2019 ◽  
Vol 59 (6) ◽  
pp. 1921-1923 ◽  
Author(s):  
Kathleen Y. Wang ◽  
David F. Friedman ◽  
Sigrid Payne DaVeiga
Keyword(s):  
Human Serum Albumin ◽  
Hypersensitivity Reaction ◽  
Serum Albumin ◽  
Human Serum ◽  
Immediate Hypersensitivity
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