Effect of topical florfenicol, terbinafine and mometasone furoate ear drops on adrenocortical function in healthy small breed dogs with bilateral otitis externa

2021 ◽  
Author(s):  
Sarrah Hoppers ◽  
Elizabeth Drake ◽  
Linda A. Frank ◽  
Xiaocun Sun
Keyword(s):  
Otitis Externa ◽  
Mometasone Furoate ◽  
Adrenocortical Function ◽  
Ear Drops ◽  
Small Breed

A Double-Blind Comparative Study of Otoseptil Ear Drops and Otosporin Ear Drops in Otitis Externa

1976 ◽  
Vol 4 (1) ◽  
pp. 79-81 ◽  
Author(s):  
D J G Bain
Keyword(s):  
Comparative Study ◽  
Otitis Externa ◽  
Fungal Infections ◽  
Double Blind ◽  
Ear Drops

A double-blind comparative study of Otoseptil Ear Drops and Otosporin Ear Drops in otitis externa in fifty-eight patients revealed them both to be equally effective in a series with very few fungal infections. In view of the normally high proportion of infections including fungi, there are obvious advantages in using Otoseptil Ear Drops.

Ciprofloxacin plus fluocinolone acetonide versus ciprofloxacin alone in the treatment of diffuse otitis externa

2014 ◽  
Vol 128 (7) ◽  
pp. 591-598 ◽  
Author(s):  
J Lorente ◽  
F Sabater ◽  
M P Rivas ◽  
J Fuste ◽  
J Risco ◽  
...  
Keyword(s):  
Adverse Events ◽  
Clinical Cure ◽  
Otitis Externa ◽  
Fluocinolone Acetonide ◽  
Double Blind Study ◽  
Double Blind ◽  
Parallel Group ◽  
Excellent Safety Profile ◽  
The Mean ◽  
Ear Drops

AbstractObjective:We aimed to evaluate the clinical efficacy of ciprofloxacin plus fluocinolone acetonide (antibiotic plus corticosteroid) ear drops compared to ciprofloxacin (antibiotic) ear drops in diffuse otitis externa.Methods:This was a multicentre, randomised, parallel-group, double-blind study involving 590 patients of both sexes aged 7 years or older.Results:The rate of clinical cure was higher (p = 0.01) with ciprofloxacin plus fluocinolone acetonide than with ciprofloxacin alone. The mean total symptom score was lower with ciprofloxacin plus fluocinolone acetonide (p = 0.005). No differences were found in the percentage of patients reporting resolution of otalgia between patients receiving ciprofloxacin plus fluocinolone acetonide and patients receiving only ciprofloxacin. Resolution of oedema and otorrhoea (p = 0.003 and p = 0.002, respectively) was higher with ciprofloxacin plus fluocinolone acetonide, as was eradication or presumed eradication (p = 0.003). There were eight mild adverse events, three with the ciprofloxacin plus fluocinolone acetonide combination (not related to the treatment) and five when ciprofloxacin was administered alone (directly related to the treatment).Conclusions:Ciprofloxacin plus fluocinolone acetonide is a more effective treatment for diffuse otitis externa than ciprofloxacin alone. The ciprofloxacin plus fluocinolone acetonide combination also has an excellent safety profile.

Dexamethasone phosphate in antibiotic ear drops for the treatment of acute bacterial otitis externa

2008 ◽  
Vol 24 (8) ◽  
pp. 2339-2347 ◽  
Author(s):  
Ralph Mösges ◽  
Timo Schröder ◽  
Christian M. Baues ◽  
Kurtuluş Şahin
Keyword(s):  
Otitis Externa ◽  
Dexamethasone Phosphate ◽  
Ear Drops

Relapsing malignant otitis externa successfully treated with ciprofloxacin

1988 ◽  
Vol 102 (10) ◽  
pp. 872-876 ◽  
Author(s):  
G. A. J. Morrison ◽  
C. M. Bailey
Keyword(s):  
Cranial Nerve ◽  
Otitis Externa ◽  
Diabetic Control ◽  
Cranial Nerve Involvement ◽  
Parenteral Antibiotic ◽  
Malignant Otitis Externa ◽  
Oral Ciprofloxacin ◽  
Antibiotic Agents ◽  
Ear Drops ◽  
Antibiotic Courses

AbstractTwo cases are presented, both patients with advanced maligant otitis externa.The antibiotic ciprofloxacin has strong anti-pseudomonal activity. It was given orally for six months to both patients, following administration of the traditional parenteral antibiotic courses, and in each case the disease has been extinguished. We therefore recommend that the management of patients shown to have malignant otitis externa should include strict diabetic control, regular local aural toilet, gentamicin ear drops and a six week course of parenteral antipseudomonal antibiotic agents (usually gentamicin and azlocillin) together with metronidazole to cover any anaerobic element in the infection. This regimen should be followed by a six month course of oral ciprofloxacin (750 mg b. d.). Indium scans should be used to monitor recovery. We believe that this regimen can significantly reduce the morbidity and mortality of patients suffering from malignant otitis externa with cranial nerve involvement.

Optimising the use of otowicks in otitis externa

2017 ◽  
Vol 131 (9) ◽  
pp. 809-812 ◽  
Author(s):  
S Bola ◽  
M Rashid ◽  
S Hickey
Keyword(s):  
Bacterial Growth ◽  
Initial Dose ◽  
Otitis Externa ◽  
Agar Plate ◽  
Ear Canal ◽  
Sterile Saline ◽  
Continuous Application ◽  
Ear Canals ◽  
Ear Drops

AbstractObjective:Otowicks are used to treat otitis externa with significant ear canal oedema. This study investigates how well drops penetrate through to reach the deep canal and whether it is safe to leave otowicks in the canal for more than 2 days.Methods:Sterile otowicks were inserted into mock ear canals and vertically over pseudomonas-seeded agar plates whilst gentamicin or ciprofloxacin drops were administered. The time taken for drops to penetrate through the otowick was recorded. Separately, pseudomonas-seeded otowicks were treated with saline or antibacterial drops. The penetrating drops were observed for bacterial growth on sterile agar.Results:It took six drops before penetration occurred for both antibiotics. When sterile saline drops were applied to bacterially contaminated otowicks, the penetrating drops displayed bacterial growth on agar, indicating that pseudomonas penetrated through the otowick. However, when antibiotic drops were applied, penetrating drops showed no bacterial growth on the corresponding agar plate.Conclusion:Bacteria can penetrate otowicks but this is prevented by continuous application of antibacterial ear drops. Ear wicks need priming with six drops before starting a regimen, so that the initial dose is fully absorbed.

scholarly journals The pH of Commonly used Topical Ear Drops in the Treatment of Otitis Externa

2011 ◽  
Vol 90 (4) ◽  
pp. 160-162 ◽  
Author(s):  
Chee-Yean Eng ◽  
Amged S. El-Hawrani
Keyword(s):  
Otitis Externa ◽  
Ear Drops

scholarly journals Experience of using the ear gel «Osurnia» in dogs with otitis externa

2019 ◽  
Vol 2019 (1) ◽  
pp. 40-45
Author(s):  
Лидия Куприянова ◽  
Lidiya Kupriyanova
Keyword(s):  
Clinical Efficacy ◽  
Stress Level ◽  
Significant Influence ◽  
Otitis Externa ◽  
Ear Canal ◽  
Good Tolerability ◽  
High Effectiveness ◽  
Pre Treatment ◽  
Ear Drops

The article presents the data on the clinical efficacy of ear gel «Osurnia» in 20 dogs weighing from 3 to 51 kg with the mixed microbial otitis externa cases at two-times instillation with an interval of 7 days with pre-treatment using cleaning lotion. The drug was studied in comparison with control three-component complex ear drops. The results of the studies were controlled clinically and cytologically after 7 and 14 days, respectively. Our experience has proved the high effectiveness of the drug «Osurnia» in regard to yeast and a coccial microbial. The significant influence of the preparation «Osurnia» on the chronic lichenisation and stenosis in the ear canal as well as the good tolerability «Osurnia» by all the animals are noted. Due to the rare administration of the drug the stress level in animals subjected to treatment is significantly reduced, as well as the risk of non-fulfillment of appointments by owners is minimized.

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