Oral dexamethasone sodium phosphate solution significantly reduces pruritus and clinical lesions in feline hypersensitivity dermatitis: an open‐label study

2021 ◽  
Author(s):  
Dayle McClintock ◽  
Michaela Austel ◽  
Robert M. Gogal ◽  
Frane Banovic
Keyword(s):  
Sodium Phosphate ◽  
Phosphate Solution ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Dexamethasone Sodium Phosphate ◽  
Oral Dexamethasone ◽  
Sodium Phosphate Solution

P23 Tolerability of prednisolone and dexamethasone in children in saudi arabia and the united kingdom

2018 ◽  
Vol 103 (2) ◽  
pp. e2.26-e2
Author(s):  
Fahad Aljebab ◽  
Mofadhi Alanazi ◽  
Imti Choonara ◽  
Sharon Conroy
Keyword(s):  
Saudi Arabia ◽  
Abdominal Pain ◽  
Sodium Phosphate ◽  
Oral Prednisolone ◽  
Phosphate Solution ◽  
List Type ◽  
Dexamethasone Sodium Phosphate ◽  
Significant Difference ◽  
Sodium Phosphate Solution ◽  
The Uk

BackgroundCorticosteroids are used to treat conditions including acute asthma and croup where they are often given in short-courses. This study evaluated the tolerability and palatability of oral prednisolone and dexamethasone in children in Saudi Arabia (SA) and the UK.MethodsA prospective observational/interview study was performed. Palatability was evaluated by asking patient/parent’s opinions of the taste and acceptability of the medication. Children pointed at the appropriate face on a scale depicting: 1 ‘dislike very much’, 2 ‘dislike a little’, 3 ‘not sure’, 4 ‘like a little’ and 5 ‘like very much’.1 Tolerability, in particular nausea, vomiting and abdominal pain was evaluated by direct questioning of the patient/parents after each administration. Data was collected over three months in each centre. Patients aged 2–18 years treated with oral prednisolone or dexamethasone in hospital were approached to participate.ResultsIn SA, 122 patients (89 asthma, 33 croup), aged 2–10 years (mean=4.3) were recruited: 52 received prednisolone base tablets; 37 prednisolone sodium phosphate syrup; 33 dexamethasone elixir. In the UK, of 133 patients (80 asthma, 53 croup) aged 2–16 years (mean=4.9): 38 received prednisolone base tablets; 42 prednisolone sodium phosphate soluble tablets; 53 dexamethasone sodium phosphate oral solution.SA: Day 1 prednisolone base tablet palatability scores: 1 (88.5%); 2 (11.5%). Day 2 scores: 1 (64.4%); 2 (28.9%); 3 (6.7%). Day 1 prednisolone sodium phosphate solution palatability scores: 1 (48.6%); 2 (40.5%); 3 (10.8%). Day 2 scores: 1 (10.8%); 2 (67.6%); 3 (21.6%). Day 1 dexamethasone elixir palatability scores: 1 (27.3%); 2 (48.5%); 3 (24.2%).UK: Day 1 prednisolone base tablet palatability scores: 1 (76.3%); 2 (13.1%); 3 (5.3%); 4 (5.3%). Day 2 scores: 1 (61.3%); 2 (19.4%); 3 (16.1%); 4 (3.2%). Day 1 prednisolone sodium phosphate soluble tablet palatability scores: 1 (35.7%); 2 (26.2%); 3 (23.8%); 4 (11.9%) 5 (2.4%). Day 2 scores: 1 (16.7%); 2 (58.2%); 3 (16.7%); 4 (4.2%); 5 (4.2%). Day 1 dexamethasone sodium phosphate solution palatability scores: 1 (5.7%); 2 (28.3%); 3 (37.7%); 4 (17%); 5 (11.3%).Dexamethasone sodium phosphate solution had the highest palatability scores (P<706;0.0001). The score was lowest for prednisolone base tablets in both centres (P<0.0001).In SA prednisolone base tablets were associated with more cases of nausea (24 vs 7) and vomiting (5 vs 0) than prednisolone sodium phosphate syrup (p=0.008 and p=0.073 respectively). In the UK vomiting occurred significantly more frequently with prednisolone base tablets (8) than prednisolone sodium phosphate soluble tablets (2) (p=0.041).In both centres dexamethasone was associated with less side effects but with no significant difference between the formulations. Vomiting (1 vs 0), nausea (7 vs 3) and abdominal pain (10 vs 8) occurred more with dexamethasone sodium phosphate solution than dexamethasone elixir (p=1, p=0.53 and p=0.55 respectively).ConclusionsDexamethasone sodium phosphate solution was the most palatable preparation. Prednisolone base tablets were rated the least palatable and were also the least well tolerated. Palatability scores seemed to improve with second doses.ReferenceH. Hames H, Seabrook JA, Matsui D, Rieder MJ, Joubert GI. A palatability study of a flavoured dexamethasone preparation versus prednisolone liquid in children. Can. J. Clin. PharmacolJanuary 2008;15(1):e95–8.

scholarly journals Observational study on the palatability and tolerability of oral prednisolone and oral dexamethasone in children in Saudi Arabia and the UK

2017 ◽  
Vol 103 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Fahad Aljebab ◽  
Mofadhi Alanazi ◽  
Imti Choonara ◽  
Sharon Conroy
Keyword(s):  
Sodium Phosphate ◽  
Oral Prednisolone ◽  
Oral Solution ◽  
Phosphate Solution ◽  
Dexamethasone Sodium Phosphate ◽  
Short Course ◽  
Daily Dose ◽  
Oral Corticosteroids ◽  
Sodium Phosphate Solution ◽  
The Uk

BackgroundShort-course oral corticosteroids are routinely used to treat acute asthma and croup. We evaluated their tolerability and palatability in Saudi Arabian (SA) and UK children.MethodsProspective observational/interview study (3 months in each country). Palatability was evaluated using a 5-point facial Hedonicscale and tolerability by direct questioning of patient/parents.ResultsIn SA, of 122 patients (2–10 years) recruited, 52 received prednisolone base tablets, 37 prednisolone sodium phosphate syrup and 33 received dexamethasone elixir. In the UK, of 133 patients (2–16 years), 38 received prednisolone base tablets (mainly crushed and dispersed), 42 prednisolone sodium phosphate soluble tablets and 53 received dexamethasone sodium phosphate oral solution.In both countries, dexamethasone had the highest palatability scores (SA mean: 1.97; UK mean: 3) and prednisolone base tablets had the lowest (SA mean: 1.12; UK mean: 1.39). Palatability scores improved for all formulations of prednisolone with each subsequent daily dose.In SA, prednisolone base tablets were associated with more nausea (24vs7 patients) and vomiting (5vs0 patients) than sodium phosphate syrup (p=0.008 and p=0.073, respectively). In the UK, vomiting occurred more frequently with prednisolone base (8 patients) than sodium phosphate soluble tablets (2 patients) (p=0.041).In both centres, dexamethasone was associated with less side effects. Vomiting (1vs0 patients), nausea (7vs3 patients) and abdominal pain (10vs8 patients) occurred more with dexamethasone sodium phosphate solution than dexamethasone elixir.ConclusionsDexamethasone sodium phosphate solution was the most palatable preparation. Prednisolone base tablets were rated least palatable and were least well tolerated. Palatability scores improved with each dose taken.

Azathloprise in refractory sprue. Results from a prospective open-label study

2001 ◽  
Vol 120 (5) ◽  
pp. A392-A392 ◽  
Author(s):  
S NIVELONI ◽  
A CHERNAVSKY ◽  
S PEDREIRA ◽  
R MAZURE ◽  
H VAZQUEZ ◽  
...  
Keyword(s):  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Refractory Sprue

Weighing the Evidence: Can We Believe an Open-Label Study?

2006 ◽  
Vol 16 (4) ◽  
pp. 39-39
Author(s):  
B. L. Wiedermann
Keyword(s):  
Open Label ◽  
Open Label Study ◽  
Label Study

Open-Label Study (ARIDO) Evaluating Long-Term Safety of Topical Glycopyrronium Tosylate (GT) in Patients with Axillary Hyperhidrosis

2017 ◽  
Vol 1 ◽  
pp. s95 ◽  
Author(s):  
Dee Anna Glaser ◽  
Adelaide A Hebert ◽  
Alexander Nast ◽  
William P Werschler ◽  
Stephen Shideler ◽  
...  
Keyword(s):  
Axillary Hyperhidrosis ◽  
Open Label ◽  
Open Label Study ◽  
Label Study

Abstract Not AvailableDisclosure: Study supported by Dermira.

Nefazodone Treatment of Adolescent Depression: An Open-Label Study of Response and Biochemistry

2000 ◽  
Vol 12 (2) ◽  
pp. 97-100 ◽  
Author(s):  
Paul Goodnick ◽  
Cecilia Jorge ◽  
Thomas Hunter ◽  
Adarsh Kumar
Keyword(s):  
Adolescent Depression ◽  
Open Label ◽  
Open Label Study ◽  
Label Study

Treatment of Somatization Disorder With Nefazodone: A Prospective, Open-Label Study

2001 ◽  
Vol 13 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Matthew Menza ◽  
Marc Lauritano ◽  
Lesley Allen ◽  
Melissa Warman ◽  
Frank Ostella ◽  
...  
Keyword(s):  
Somatization Disorder ◽  
Open Label ◽  
Open Label Study ◽  
Label Study
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