Characterisation of the serum cytokine profile in feline atopic skin syndrome

2021 ◽  
Author(s):  
Cheryl Vargo ◽  
Robert Gogal ◽  
James Barber ◽  
Michaela Austel ◽  
Frane Banovic
Keyword(s):  
Cytokine Profile ◽  
Serum Cytokine ◽  
Atopic Skin

Kinetics of Serum Cytokine Profile in Mice after Injection of Supernatants of Group A Streptococci Culture

2019 ◽  
Vol 167 (3) ◽  
pp. 367-370 ◽  
Author(s):  
Т. А. Danilova ◽  
G. А. Danilina ◽  
А. А Аdzhieva ◽  
A. G. Minko
Keyword(s):  
Cytokine Profile ◽  
Group A Streptococci ◽  
Serum Cytokine ◽  
Group A ◽  
Kinetics Of

scholarly journals Analysis of Serum Cytokine Profile in Pemphigus

2017 ◽  
Vol 29 (4) ◽  
pp. 438 ◽  
Author(s):  
Sang Hee Lee ◽  
Won Jin Hong ◽  
Soo-Chan Kim
Keyword(s):  
Cytokine Profile ◽  
Serum Cytokine

scholarly journals Serum Cytokine Profile, Beta-Hexosaminidase A Enzymatic Activity and GM2 Ganglioside Levels in the Plasma of a Tay-Sachs Disease Patient after Cord Blood Cell Transplantation and Curcumin Administration: A Case Report

Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1007
Author(s):  
Alisa A. Shaimardanova ◽  
Daria S. Chulpanova ◽  
Valeriya V. Solovyeva ◽  
Ekaterina E. Garanina ◽  
Ilnur I. Salafutdinov ◽  
...  
Keyword(s):  
Blood Cell ◽  
Enzymatic Activity ◽  
Cord Blood ◽  
Cell Transplantation ◽  
Cytokine Profile ◽  
Serum Cytokine ◽  
Α Subunit ◽  
Cord Blood Cell ◽  
Tay Sachs Disease ◽  
Hexosaminidase A

Tay-Sachs disease (TSD) is a progressive neurodegenerative disorder that occurs due to a deficiency of a β hexosaminidase A (HexA) enzyme, resulting in the accumulation of GM2 gangliosides. In this work, we analyzed the effect of umbilical cord blood cell transplantation (UCBCT) and curcumin administration on the course of the disease in a patient with adult TSD. The patient’s serum cytokine profile was determined using multiplex analysis. The level of GM2 gangliosides in plasma was determined using mass spectrometry. The enzymatic activity of HexA in the plasma of the patient was assessed using a fluorescent substrate assay. The HexA α-subunit (HexA) concentration was determined using ELISA. It was shown that both UCBCT and curcumin administration led to a change in the patient’s cytokine profile. The UCBCT resulted in an increase in the concentration of HexA in the patient’s serum and in an improvement in the patient’s neurological status. However, neither UCBCT nor curcumin were able to alter HexA activity and the level of GM2 in patient’s plasma. The data obtained indicate that UCBCT and curcumin administration can alter the immunity of a patient with TSD, reduce the level of inflammatory cytokines and thereby improve the patient’s condition.

Analysis of the Serum Cytokine Profile in Allergic Patients Opens a Way to Personalized Treatment of Allergy

2019 ◽  
Vol 166 (6) ◽  
pp. 770-773
Author(s):  
I. V. Bogdanov ◽  
E. I. Finkina ◽  
D. N. Melnikova ◽  
A. A. Tagaev ◽  
Т. V. Ovchinnikova
Keyword(s):  
Cytokine Profile ◽  
Personalized Treatment ◽  
Serum Cytokine

Serum cytokine profile during subcutaneous implantation of the decellularized esophagus matrix in rats

2020 ◽  
Vol 35 (3) ◽  
pp. 446-455
Author(s):  
Karina Melkonyan ◽  
Ramazan Nakokhov ◽  
Tatyana Rusinova ◽  
Yana Yutskevich ◽  
Ilya Bykov ◽  
...  
Keyword(s):  
Dynamic Change ◽  
Healing Process ◽  
Cytokine Profile ◽  
Control Group ◽  
Wound Healing Process ◽  
Subcutaneous Implantation ◽  
Serum Cytokine ◽  
Serum Samples ◽  
Rat Serum ◽  
Gm Csf

Aim to study non-specific immune response characteristics (serum cytokine profile) in rats after subcutaneous implantation of the decellularized esophagus matrix. Methods Data were obtained in Wistar rats. The rats underwent subcutaneous implantation of decellularized esophagus (DE) and native allogeneic esophagus (NE). Explantation of sampling were carried out on the 7th, 14th and 21st day of the experiment. Explanted NEs and DEs were processed for histologic examination. The content of IL1α, IL2, IL4, IL17А, TNFα, IFNγ and GM-CSF in serum samples were tested by ELISA. Results In rat serum with DEs on the 7th day of the experiment it was significant increase in IL1α level in comparison with control group, IL2, TNFα, IL4 levels did not differ from the control group levels that indicates the stabilization of inflammation. The content of IL17A, IFNγ and GM-CSF significantly decreased compared to control. On the 14th day, IL17A concentration analysis showed a sharp decrease in comparison with the the 7th experimental day. We found decrease in IL1α level vs control group and decrease in IFNγ level vs 7th day. On the 21st experimental day was shown a significant decrease in the IL17A, IFNγ and IL1α content in DE rats. Conclusions It was found dynamic change in studied rat cytokine concentrations that correspond to favourable clinical picture in DE group in comparison with an active inflammatory reaction in NE group. IL1α, IL4, IL17A and IFNγ concentrations reflect positive dynamics of the wound healing process and the absence of local inflammation and rejection of decellularized matrices.

Thrombocytopenia in critically ill patients with severe sepsis/septic shock: Prognostic value and association with a distinct serum cytokine profile

2016 ◽  
Vol 32 ◽  
pp. 9-15 ◽  
Author(s):  
Panagiotis Tsirigotis ◽  
Spiros Chondropoulos ◽  
Frantzeska Frantzeskaki ◽  
Maria Stamouli ◽  
Konstantinos Gkirkas ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Prognostic Value ◽  
Cytokine Profile ◽  
Serum Cytokine

Serum Cytokine Profile and IGG4 Levels in Japanese Patients with Inflammatory Bowel Disease

2017 ◽  
Vol 152 (5) ◽  
pp. S767
Author(s):  
Ryo Katsumata ◽  
Manabu Ishii ◽  
Kyosuke Goda ◽  
Shinya Fukushima ◽  
Takahisa Murao ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Japanese Patients ◽  
Cytokine Profile ◽  
Serum Cytokine ◽  
Inflammatory Bowel
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