Comparison between the Mission Plus device and gold standard methods for measuring hemoglobin concentrations and packed cell volumes in cattle

2021 ◽  
Author(s):  
Luciana M. Heller ◽  
Dina M. B. Zapa ◽  
Rubens D. Melo‐Junior ◽  
Alliny S. A. Cavalcante ◽  
Luiz F. M. Couto ◽  
...  
Keyword(s):  
Gold Standard ◽  
Standard Methods ◽  
Cell Volumes

scholarly journals The Slow March toward Rapid Phenotypic Antimicrobial Susceptibility Testing: Are We There Yet?

2018 ◽  
Vol 56 (4) ◽  
pp. e01999-17 ◽  
Author(s):  
Christopher D. Doern
Keyword(s):  
Antimicrobial Susceptibility ◽  
Rapid Growth ◽  
Gold Standard ◽  
Historical Perspective ◽  
Susceptibility Testing ◽  
Turnaround Time ◽  
Antimicrobial Susceptibility Testing ◽  
Standard Methods ◽  
Phenotypic Susceptibility ◽  
Made In

ABSTRACT Antimicrobial susceptibility testing (AST) provides critical information for the management of patients with infections. The gold standard methods for assessing organism susceptibility are still based on growth and require incubation over relatively long periods of time. Until now, little progress has been made in developing rapid, growth-based, phenotypic AST systems. This commentary puts the recently FDA-cleared Accelerate PhenoTest (P. Pancholi et al., J Clin Microbiol 56:e01329-17, 2018, https://doi.org/10.1128/JCM.01329-17) in context by providing a historical perspective on attempts to accelerate phenotypic susceptibility results. In addition, some promising new innovations that promise to shorten the turnaround time for phenotypic AST will be briefly reviewed.

scholarly journals Elucidating Methods for Isolation and Quantification of Exosomes: A Review

2021 ◽  
Author(s):  
Talitha Keren Kurian ◽  
Soumyabrata Banik ◽  
Dharshini Gopal ◽  
Shweta Chakrabarti ◽  
Nirmal Mazumder
Keyword(s):  
Gold Standard ◽  
Tumor Metastasis ◽  
Biological Fluids ◽  
Size Exclusion ◽  
Nanoparticle Tracking Analysis ◽  
Standard Methods ◽  
Advantages And Disadvantages ◽  
Resistive Pulse ◽  
Tunable Resistive Pulse Sensing ◽  
Exclusion Chromatography

AbstractExosomes are the smallest extracellular vesicles present in most of the biological fluids. They are found to play an important role in cell signaling, immune response, tumor metastasis, etc. Studies have shown that these vesicles also have diagnostic and therapeutic roles for which their accurate detection and quantification is essential. Due to the complexity in size and structure of exosomes, even the gold standard methods face challenges. This comprehensive review discusses the various standard methods such as ultracentrifugation, ultrafiltration, size-exclusion chromatography, precipitation, immunoaffinity, and microfluidic technologies for the isolation of exosomes. The principle of isolation of each method is described, as well as their specific advantages and disadvantages. Quantification of exosomes by nanoparticle tracking analysis, flow cytometry, tunable resistive pulse sensing, electron microscopy, dynamic light scattering, and microfluidic devices are also described, along with the applications of exosomes in various biomedical domains.

scholarly journals Validity of Wrist-Worn Activity Trackers for Estimating VO2max and Energy Expenditure

2019 ◽  
Vol 16 (17) ◽  
pp. 3037 ◽  
Author(s):  
Stefanie Passler ◽  
Julian Bohrer ◽  
Lukas Blöchinger ◽  
Veit Senner
Keyword(s):  
Health Care ◽  
Energy Expenditure ◽  
Gold Standard ◽  
Healthy Subjects ◽  
Intraclass Correlation ◽  
Standard Methods ◽  
Paired Sample ◽  
Activity Trackers ◽  
Health Care Applications ◽  
Scientific Validation

Activity trackers are a simple and mostly low-priced method to capture physiological parameters. Despite the high number of wrist-worn devices, there is a lack of scientific validation. The purpose of this study was to assess whether the activity trackers represent a valid alternative to gold-standard methods in terms of estimating energy expenditure (EE) and maximum oxygen uptake (VO2max). Twenty-four healthy subjects participated in this study. In total, five commercially available wrist-worn devices were tested with regard to their validity of EE and/or VO2max. Estimated values were compared with indirect calorimetry. Validity of the activity trackers was determined by paired sample t-tests, mean absolute percentage errors (MAPE), Intraclass Correlation Coefficient, and Bland-Altman plots. Within the tested devices, differences in scattering in VO2max and EE could be observed. This results in a MAPE > 10% for all evaluations, except for the VO2max-estimation of the Garmin Forerunner 920XT (7.3%). The latter significantly underestimates the VO2max (t(23) = –2.37, p = 0.027), whereas the Garmin Vivosmart HR significantly overestimates the EE (t(23) = 2.44, p = 0.023). The tested devices did not show valid results concerning the estimation of VO2max and EE. Hence, the current wrist-worn activity trackers are most likely not accurate enough to be used for neither purposes in sports, nor in health care applications.

scholarly journals Nailfold videocapillaroscopy in internal medicine

2015 ◽  
Vol 9 (3) ◽  
pp. 234 ◽  
Author(s):  
Paola Faggioli ◽  
Antonio Tamburello ◽  
Alba Sciascera ◽  
Adele Giulia Gilardi ◽  
Antonino Mazzone
Keyword(s):  
Internal Medicine ◽  
Systemic Sclerosis ◽  
Gold Standard ◽  
Imaging Technique ◽  
Raynaud’S Phenomenon ◽  
Nailfold Capillaroscopy ◽  
Nailfold Videocapillaroscopy ◽  
Standard Methods ◽  
Non Invasive ◽  
Rheumatologic Diseases

Capillaroscopy is an actual inexpensive imaging technique, used to examine, non-invasively and safely, the morphology of nailfold dermal papillary capillaries. Many studies agree in the statement that the capillaroscopy is one of the gold standard methods for non-invasive examination of the microcirculation and it plays an important role in screening in Raynaud’s phenomenon and in monitoring of systemic sclerosis and other rheumatologic diseases. There are also many reports on the possible use of nailfold capillaroscopy in the diagnosis and monitoring of many other diseases in internal medicine.

Glycosylated Biomarker Sensors: Advancements in Prostate Cancer Diagnosis

2021 ◽  
Author(s):  
Siti Fatimah Abd Rahman ◽  
Mohd Khairuddin Md Arshad ◽  
Subash Gopinath ◽  
Mohamad Faris Mohamad Fathil ◽  
Frédéric Sarry ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Cancer Diagnosis ◽  
Gold Standard ◽  
Specific Antigen ◽  
Prostate Cancer Diagnosis ◽  
Standard Methods ◽  
Psa Screening

Prostate cancer is currently diagnosed using the conventional gold standard methods using prostate-specific antigen (PSA) as a selective biomarker. However, lack of precision in PSA screening has resulted in needless...

scholarly journals Evaluation of the Intel RealSense T265 for tracking natural human head motion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Peter Hausamann ◽  
Christian B. Sinnott ◽  
Martin Daumer ◽  
Paul R. MacNeilage
Keyword(s):  
Gold Standard ◽  
Angular Position ◽  
Human Head ◽  
Clinical Diagnostics ◽  
Optical Tracking ◽  
Head Motion ◽  
Natural Environments ◽  
Standard Methods ◽  
Wide Range ◽  
Walking Speeds

AbstractAccurate and robust tracking of natural human head motion in natural environments is important for a number of applications including virtual and augmented reality, clinical diagnostics, as well as basic scientific research. IMU provide a versatile solution for recording inertial data including linear acceleration and angular velocity, but reconstructing head position is difficult or impossible. This problem can be solved by incorporating visual data using a technique known as visual-inertial simultaneous localization and mapping (VI-SLAM). A recently released commercial solution, the Intel RealSense T265, uses a proprietary VI-SLAM algorithm to estimate linear and angular position and velocity, but the performance of this device for tracking of natural human head motion in natural environments has not yet been comprehensively evaluated against gold-standard methods. In this study, we used a wide range of metrics to evaluate the performance of the T265 with different walking speeds in different environments, both indoor and outdoor, against two gold-standard methods, an optical tracking system and a so-called perambulator. Overall, we find that performance of the T265 relative to these gold-standard methods is most accurate for slow to normal walking speeds in small- to medium-sized environments. The suitability of this device for future scientific studies depends on the application; data presented here can be useful in making that determination.

Even gold standard methods of body water measurement are not always in perfect agreement

2018 ◽  
Vol 34 (1) ◽  
pp. 185-186 ◽  
Author(s):  
Indranil Dasgupta ◽  
David Keane ◽  
Ulrich Moissl ◽  
Elizabeth Lindley
Keyword(s):  
Gold Standard ◽  
Body Water ◽  
Perfect Agreement ◽  
Standard Methods ◽  
Water Measurement

scholarly journals Validation of two informant-based screening instruments for personality disorders in a psychiatric outpatient population

2013 ◽  
Vol 2 (2) ◽  
pp. 133
Author(s):  
Sara Germans ◽  
Guus L.Van Heck ◽  
Paul PG Hodiamont ◽  
Danielle Elshoff ◽  
Habib Kondakci ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Personality Disorders ◽  
Sensitivity And Specificity ◽  
Predictive Validity ◽  
Gold Standard ◽  
The Other ◽  
Self Report ◽  
Screening Instruments ◽  
Predictive Values ◽  
Standard Methods

Purpose: The predictive validity of two informant-based screening instruments for personality disorders (PDs), the Standardized Assessment of Personality (SAP) and a short eight-item version (SAPAS-INF), were studied in 103 Dutch psychiatric outpatients, using the SCID-II as the ‘gold standard’. Methods: All patients and their informants were interviewed separately and independently by different interviewers who were unaware of the results in the other conditions. Results: According to the SCID-II, 66 patients had at least one personality disorder (PD). The SAP correctly classified 72% of all participants in the category PD present/absent. The sensitivity and specificity were 69% and 76%, respectively. The positive and negative predictive values were 84% and 58%. The SAPAS-INF, using a cut-off score of 3, correctly classified 70%; the sensitivity and specificity were 76% and 58%, respectively. The positive and the negative predictive values were 77% and 57%. Conclusion: These results show that the informant-based SAP as well as the shorter informant-based SAPAS-INF are adequate; though rather moderate screening instruments for identifying PD. The SAP and the SAPAS-INF, however, both performed worse than the SAPAS-SR, which is based on the patient’s self-report. Therefore, it is concluded that the SAP or the SAPAS-INF can be used as a satisfactory screening instruments for the presence/absence of PD in those cases where patients themselves are unable to provide the required information.

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