Method validation, reference values, and characterization of acute‐phase protein responses to experimentally induced inflammation and bluetongue virus infection in the Iberian ibex

2019 ◽  
Vol 48 (4) ◽  
pp. 695-701
Author(s):  
Josep Pastor ◽  
Ester Bach ◽  
Arián Ráez‐Bravo ◽  
Jorge Ramón López‐Olvera ◽  
Asta Tvarijonaviciute ◽  
...  
Keyword(s):  
Virus Infection ◽  
Method Validation ◽  
Acute Phase ◽  
Reference Values ◽  
Bluetongue Virus ◽  
Acute Phase Protein ◽  
Iberian Ibex ◽  
Phase Protein ◽  
Experimentally Induced

scholarly journals The Concentration of Apolipoprotein A-I Decreases during Experimentally Induced Acute-Phase Processes in Pigs

2005 ◽  
Vol 73 (5) ◽  
pp. 3184-3187 ◽  
Author(s):  
R. Carpintero ◽  
M. Piñeiro ◽  
M. Andrés ◽  
M. Iturralde ◽  
M. A. Alava ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Protein ◽  
Streptococcus Suis ◽  
Actinobacillus Pleuropneumoniae ◽  
Sterile Inflammation ◽  
Initial Values ◽  
Apolipoprotein A ◽  
Phase Protein ◽  
Experimentally Induced

ABSTRACT In this work, apolipoprotein A-I (ApoA-I) was purified from pig sera. The responses of this protein after sterile inflammation and in animals infected with Actinobacillus pleuropneumoniae or Streptococcus suis were investigated. Decreases in the concentrations of ApoA-I, two to five times lower than the initial values, were observed at 2 to 4 days. It is concluded that ApoA-I is a negative acute-phase protein in pigs.

scholarly journals CHARACTERIZATION OF A HUMAN ACUTE PHASE PROTEIN FOUND IN ASSOCIATION WITH RUBELLA VIRUS INFECTION

1974 ◽  
Vol 139 (3) ◽  
pp. 497-511 ◽  
Author(s):  
Roger Cappel ◽  
Ann Schluederberg ◽  
Robert H. Gifford ◽  
Dorothy M. Horstmann
Keyword(s):  
Rheumatoid Arthritis ◽  
Virus Infection ◽  
Acute Phase ◽  
Rubella Virus ◽  
Acute Phase Protein ◽  
Phase Protein ◽  
Rubella Virus Infection ◽  
In Pregnancy

A precipitating antigen, rho, was first detected in the blood of persons with rubella and in rubella virus-infected cell culture fluids (1). Partially purified antigens from both sources were examined and shown to have similar properties, although antigen from serum sedimented more heterogeneously, with estimated coefficients from 15 to 21 S, while that from culture fluids sedimented in the 11–14 S region. In each case, antigen was located in the ß-1 zone after electrophoresis in agarose, and at a density of 1.305 g/ml after centrifugation in CsCl. Stability characteristics were typical of protein antigens. Immunofluorescent microscopy revealed that rubella virus induced the appearance of rho antigen scattered throughout the cytoplasm of infected cells. When cells containing antigen were exposed for 24 h to 5 µg/ml actinomycin D rho was no longer detectable, indicating the probable cellular origin of the antigen. Also, titers in medium of infected cultures showed a reduction after actinomycin treatment, but levels of the virus-specified antigen, iota, were relatively unaffected. Rho appears to be a protein common to man and many animals. In vitro, it was induced by rubella virus and by adenovirus. In vivo, rho titers were shown to be elevated after rubella virus infection and, to a lesser extent, after infection with certain other viruses. High titers were also demonstrated in women late in pregnancy and in patients with rheumatoid arthritis. In man and the chimpanzee, the appearance and decline of rho in the blood after rubella virus infection were temporally similar to the patterns of CRP, although rho seemed to be a more sensitive indicator of infection. The data presented indicate that rho is a newly recognized acute phase protein inducible by certain virus infections and by other unidentified stimuli present prominently in pregnancy and rheumatoid arthritis.

scholarly journals Characterization of the contributions of Hp-MMP 9 to the serum acute phase protein response of lipopolysaccharide challenged calves

2014 ◽  
Vol 10 (1) ◽  
Author(s):  
Charles A Hinds ◽  
Andrew J Niehaus ◽  
Christopher Premanandan ◽  
Paivi J Rajala-Schultz ◽  
Donald M Rings ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Protein ◽  
Acute Phase Protein Response ◽  
Phase Protein ◽  
Protein Response
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