What is your diagnosis? Lytic bone lesion in a dog

2019 ◽  
Vol 48 (4) ◽  
pp. 783-785
Author(s):  
Maggie R. McCourt ◽  
Erin Stayton ◽  
Caleb Weir ◽  
Alana Pavuk ◽  
Theresa E. Rizzi
Keyword(s):  
Bone Lesion ◽  
Lytic Bone Lesion

Diagnosing cranial fasciitis based on distinguishing radiological features

2008 ◽  
Vol 2 (5) ◽  
pp. 370-374 ◽  
Author(s):  
Keyne K. Johnson ◽  
Mark J. Dannenbaum ◽  
Meenakshi B. Bhattacharjee ◽  
Anna Illner ◽  
Robert C. Dauser ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Pediatric Population ◽  
Bone Lesion ◽  
Vacuum Extraction ◽  
Histopathological Findings ◽  
Radiological Features ◽  
Cranial Fasciitis ◽  
Lytic Bone Lesion ◽  
Myxoid Matrix ◽  
Painless Mass

Primary skull lesions, albeit rare in the pediatric population, have been well described and classified. These lesions are usually benign and commonly present as a painless mass. The most common lesions are epidermoid, dermoid, and Langerhans cell histiocytosis. Cranial fasciitis, encountered less frequently, is usually not considered in this differential diagnosis. Given such few cases reported, it is commonly misdiagnosed preoperatively. The authors retrospectively reviewed data obtained in 4 patients with cranial fasciitis in whom the diagnosis was based on histopathological findings. In 2 patients the onset of the lesion was spontaneous. One patient had a lesion 4 months following a vacuum extraction and subsequent cephalohematoma formation. One patient developed a lesion following a previous craniectomy. Presentation, imaging studies, and histopathological findings were all reviewed and analyzed. All patients presented with a firm nontender mass. Radiological features included a lytic bone lesion with a mildly sclerotic margin, T1 isodensity, T2 heterogeneous hyperdensity, and heterogeneous enhancement. The enhancing portion was not bright on T2-weighted MR images, likely representing the fibrous component; the nonenhancing portion was bright on T2-weighted images, likely representing the myxoid matrix. Histopathological examination revealed proliferating fibroblasts in a myxoid matrix. Cranial fasciitis is a benign, painless but rapidly growing lesion of the skull mainly limited to the pediatric population. It is histologically similar to nodular fasciitis, a fibroblastic proliferation of varying size. These lesions are often related to trauma but can also be insidious or can develop at a prior craniectomy site. The appropriate clinical picture and distinguishing radiographic features may help to differentiate cranial fasciitis from other lesions of the skull allowing for earlier intervention.

Myoepithelioma of the Skull

Neurosurgery ◽  
2012 ◽  
Vol 71 (4) ◽  
pp. E901-E904 ◽  
Author(s):  
Karen J. Fritchie ◽  
Mitchel D. Bauman ◽  
Quentin J. Durward
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Bone Lesion ◽  
Myoepithelial Cells ◽  
The Past ◽  
Lytic Bone Lesion ◽  
Initial Biopsy

Abstract BACKGROUND AND IMPORTANCE: Myoepithelioma of bone is a rare osseous tumor thought to be related to myoepithelial lesions found at other anatomic sites such as the salivary gland and skin. These tumors are composed of varying proportions of epithelial and myoepithelial cells and exhibit a spectrum of biologic behavior ranging from benign to malignant. We present the first reported case of myoepithelioma of the skull. CLINICAL PRESENTATION: A 20-year-old white woman presented with a persistent right parieto-occipital skull nodule, relating its presence to a fall on the site 2 years previously. The nodule had become painful in the past 2 months. Her past medical history and workup were otherwise unremarkable. The initial biopsy was inconclusive for diagnosis. The lytic bone lesion was subsequently resected, and histopathological examination showed a proliferation of epithelioid cells in a myxochondroid background. Fluorescence in situ hybridization studies revealed a rearrangement of the EWSR1 locus. The morphologic and molecular findings were consistent with the diagnosis of myoepithelioma of bone. CONCLUSION: Six months after surgery, the patient is doing well with no evidence of recurrence. This case illustrates the clinical presentation, histopathology, and molecular findings of a myoepithelioma of the skull with successful surgical treatment. Because myoepitheliomas with benign morphological appearance may rarely act aggressively, long-term clinical follow-up is warranted.

scholarly journals When Anemia, Atypical Plasma Cells, and a Lytic Bone Lesion are not Myeloma

2015 ◽  
Vol 8 (4) ◽  
pp. 151-152
Author(s):  
Bharat Malhotra ◽  
Thomas Schulz ◽  
K James Kallail
Keyword(s):  
Plasma Cells ◽  
Bone Lesion ◽  
Lytic Bone Lesion

scholarly journals Brown tumor due to primary hyperparathyroidism resulting in acute paraparesis: Case report and literature review

2020 ◽  
Vol 11 ◽  
pp. 355
Author(s):  
Ahmed Taha Elsayed Shaaban ◽  
Mostafa Ibrahem ◽  
Ahmed Saleh ◽  
Abdulrazzaq Haider ◽  
Abdulnasser Alyafai
Keyword(s):  
Primary Hyperparathyroidism ◽  
Bone Lesion ◽  
Excisional Biopsy ◽  
Brown Tumor ◽  
Parathyroid Tumor ◽  
Osteitis Fibrosa Cystica ◽  
Lytic Bone Lesion ◽  
Brown Tumors ◽  
Acute Paraparesis ◽  
Operative Decompression

Background: Brown tumor (Osteoclastoma) is a rare benign, focal, lytic bone lesion most commonly attributed to a parathyroid adenoma; it occurs in approximately 5% of patients with primary hyperparathyroidism, and 13% of patients with secondary hyperparathyroidism. Most tumors are located in the mandible, pelvis, ribs, and large bones; only rarely is it found in the axial spine. Case Description: A 37-year-old male with primary hyperparathyroidism presented with an MR-documented T4 and T5 brown tumor (Osteitis Fibrosa Cystica) resulting in an acute paraparesis. The patient successfully underwent excisional biopsy of an expansile, enhancing, bony destructive lesion at the T4-5 level. Subsequently, he required subtotal excision of a left upper parathyroid tumor. Conclusion: Patient with primary hyperparathyroidism may acutely present with paraparesis attributed to brown tumors of the spine warranting emergent operative decompression.

CLINICOPATHOLOGICAL STUDY OF MULTIPLE MYELOMA WITH EXPRESSION OF CD56

2021 ◽  
pp. 2-3
Author(s):  
Jina Bhattacharyya ◽  
Gabyanjali Devi
Keyword(s):  
Multiple Myeloma ◽  
Plasma Cells ◽  
Bone Lesion ◽  
Immunoglobulin Superfamily ◽  
Bone Lesions ◽  
Plasma Cell Neoplasm ◽  
Disease Characteristics ◽  
Multisystem Involvement ◽  
Lytic Bone Lesion ◽  
Cd56 Expression

Background: Multiple myeloma (MM) is a plasma cell neoplasm with spectrum of clinical presentation and multisystem involvement. CD56 (a neural cell adhesion molecule, NCAM) is a membrane glycoprotein belonging to the immunoglobulin superfamily. Normal plasma cells do not express CD56, but it is frequently expressed by malignant plasma cells in patients with MM. The present study was conducted to evaluate the expression of CD56 in MM and its association with disease characteristics. Methods: We analysed CD56 expression in 34 newly diagnosed MM cases using immunohistochemistry in bone marrow core biopsies processed routinely. Results: CD56 expression was found in 70.97% cases. The clinicopathological disease characteristics such as age, serum creatinine level, serum β2-microglobulin level and plasmablastic morphology showed no statistically signicant difference between CD56 positive and negative groups. Bone lesions were signicantly higher in positive cases than in negative cases. Conclusion: CD56 expression dene a unique clinicopathological entity in MM. Expression of CD56 correlate well with lytic bone lesion and may correlate with its pathogenesis.

Solitary Lytic Bone Lesion in an Adult with Chronic Myelogenous Leukemia

Radiology ◽  
1955 ◽  
Vol 64 (5) ◽  
pp. 724-726 ◽  
Author(s):  
James Nesbitt ◽  
Robert E. Roth
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
Bone Lesion ◽  
Myelogenous Leukemia ◽  
Lytic Bone Lesion

Lytic Bone Lesion by Brucella spp.: A Delayed Diagnosis

2017 ◽  
Vol 13 (03) ◽  
pp. 252-254 ◽  
Author(s):  
Ana Dias ◽  
Paula Estanqueiro ◽  
Manuel Salgado
Keyword(s):  
Bone Lesion ◽  
Delayed Diagnosis ◽  
Lytic Bone Lesion
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