Laboratory blood analysis in Strigiformes-Part II: plasma biochemistry reference intervals and agreement between the Abaxis Vetscan V2 and the Roche Cobas c501

2015 ◽  
Vol 44 (1) ◽  
pp. 128-140 ◽  
Author(s):  
Mélanie Ammersbach ◽  
Hugues Beaufrère ◽  
Annick Gionet Rollick ◽  
Thomas Tully
Keyword(s):  
Reference Intervals ◽  
Blood Analysis ◽  
Plasma Biochemistry ◽  
Roche Cobas

Reference intervals for reproductive hormones in prepubertal children on the automated Roche cobas e 411 analyzer

2012 ◽  
Vol 45 (15) ◽  
pp. 1206-1212 ◽  
Author(s):  
Ivana Zec ◽  
Ivana Kučak ◽  
Ilijana Begčević ◽  
Ana-Maria Šimundić ◽  
Dubravka Tišlarić-Medenjak ◽  
...  
Keyword(s):  
Reference Intervals ◽  
Reproductive Hormones ◽  
Prepubertal Children ◽  
Roche Cobas

scholarly journals Laboratory blood analysis in Strigiformes-Part I: hematologic reference intervals and agreement between manual blood cell counting techniques

2015 ◽  
Vol 44 (1) ◽  
pp. 94-108 ◽  
Author(s):  
Mélanie Ammersbach ◽  
Hugues Beaufrère ◽  
Annick Gionet Rollick ◽  
Thomas Tully
Keyword(s):  
Blood Cell ◽  
Reference Intervals ◽  
Blood Analysis ◽  
Cell Counting ◽  
Blood Cell Counting

scholarly journals Comparison of method-related reference intervals for thyroid hormones: studies from a prospective reference population and a literature review

2017 ◽  
Vol 55 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Julian H Barth ◽  
Ahai Luvai ◽  
Nuthar Jassam ◽  
Wycliffe Mbagaya ◽  
Eric S Kilpatrick ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Literature Review ◽  
Thyroid Hormones ◽  
Reference Population ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Analytical Platforms ◽  
Abbott Architect ◽  
Roche Cobas ◽  
Stimulating Hormone

Introduction Reference intervals are dependent on the reference population, the analytical methods and the way the data are handled statistically. Individual method-related differences have been studied but the comparative differences in reference intervals have not. Methods We studied a reference population of healthy adult subjects and measured free thyroxine and thyroid-stimulating hormone by the four most commonly used analytical platforms used in the UK. Subjects were excluded if they were > 65 years or had positive thyroid peroxidase antibodies. We also performed a systematic literature review of thyroid hormone reference interval studies in non-pregnant adults. Results In total, 303 subjects were recruited and 42 excluded. The central 95th centile values for thyroid-stimulating hormone (mIU/L) were Abbott Architect (0.51–3.67); Beckman Unicel DxI (0.57–3.60); Roche Cobas (0.60–4.31) and Siemens Advia Centaur XP (0.63–4.29). The 95th centile values for thyroxine (pmol/L) were Abbott Architect (10.6–15.5); Beckman Unicel DxI (7.9–13.0); Roche Cobas (12.5–19.6) and Siemens Advia Centaur XP (11.8–19.0). We identified 55 papers describing thyroid reference intervals in male and non-pregnant female adults. The values for upper and lower reference intervals by manufacturer varied but were not significantly different for thyroid-stimulating hormone but were for thyroxine. Discussion Our study demonstrates clearly that there are marked variations in the reference intervals for thyroid hormones between analytical platforms. There is an urgent need for standardization of thyroid hormone assays to permit transferability of results. Until then, guidelines will need to reflect this method-related difference.

scholarly journals Assessments of feline plasma biochemistry reference intervals for three in-house analysers and a commercial laboratory analyser

2014 ◽  
Vol 17 (8) ◽  
pp. 667-679 ◽  
Author(s):  
Randolph M Baral ◽  
Navneet K Dhand ◽  
Mark B Krockenberger ◽  
Merran Govendir
Keyword(s):  
Reference Intervals ◽  
Plasma Biochemistry ◽  
Commercial Laboratory

Paediatric reference intervals for 17 Roche cobas 8000 e602 immunoassays in the CALIPER cohort of healthy children and adolescents

2019 ◽  
Vol 57 (12) ◽  
pp. 1968-1979 ◽  
Author(s):  
Mary Kathryn Bohn ◽  
Victoria Higgins ◽  
Shervin Asgari ◽  
Felix Leung ◽  
Barry Hoffman ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Reference Values ◽  
Laboratory Tests ◽  
Clinical Decision Making ◽  
Reference Intervals ◽  
Healthy Children ◽  
Serum Samples ◽  
Clinical Laboratories ◽  
Age And Sex ◽  
Roche Cobas

Abstract Background The diagnostic utility of laboratory tests in paediatric medicine relies heavily on the availability of appropriate reference intervals (RIs). The Canadian Laboratory Initiative on Paediatric Reference Intervals (CALIPER) has established a comprehensive database of covariate-stratified RIs for many paediatric laboratory tests using a large, healthy reference population. Several automated analysers in widespread use in clinical laboratories have already been studied. Here, we extend the testing to Roche immunoassays and report, for the first time, comprehensive paediatric RIs for 17 endocrine and special chemistry markers. Methods A total of 741 healthy children and adolescents (1 day to <19 years) were recruited and serum samples were analysed for 17 immunoassays on the Roche cobas 8000 e602 Immunoassay Analyzer. Age and sex-specific RIs were established and corresponding 90% confidence intervals (CIs) were calculated in accordance with Clinical and Laboratory Standards Institute guidelines. Results Reference values for all analytes measured required age partitioning, particularly during early life and throughout adolescence. Of the 17 analytes measured, eight required sex partitioning, including ferritin, thyroid stimulating hormone (TSH), total triiodothyronine (TT3) and all fertility/sex hormones, except prolactin. Conclusions This is the first study to determine accurate paediatric RIs for Roche immunoassays. RIs were generally similar to those previously published by CALIPER on other analytical platforms, highlighting the reproducibility of age- and sex-specific trends in reference values observed across the paediatric age range. The RIs established in this study will improve the accuracy of test result interpretation and clinical decision-making in clinical laboratories utilising Roche immunoassays.

EXPLORATORY PLASMA BIOCHEMISTRY REFERENCE INTERVALS FOR URAL OWLS(STRIX URALENSIS, PALLAS 1771)FROM THE AUSTRIAN REINTRODUCTION PROJECT

2016 ◽  
Vol 47 (2) ◽  
pp. 486-492
Author(s):  
Alexandra Scope ◽  
Ilse Schwendenwein ◽  
Gabriela Stanclova ◽  
Angela Vobornik ◽  
Richard Zink
Keyword(s):  
Reference Intervals ◽  
Plasma Biochemistry

Pediatric reference intervals for 28 chemistries and immunoassays on the Roche cobas® 6000 analyzer—A CALIPER pilot study

2010 ◽  
Vol 43 (13-14) ◽  
pp. 1045-1050 ◽  
Author(s):  
Vathany Kulasingam ◽  
Benjamin P. Jung ◽  
Ivan M. Blasutig ◽  
Sanaz Baradaran ◽  
Man Khun Chan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Reference Intervals ◽  
Roche Cobas

scholarly journals Method comparison of three serum free light chain assays on the Roche Cobas 6000 c501 chemistry analyzer

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Dieuwertje Augustijn ◽  
Joannes F. M. Jacobs ◽  
Henk Russcher
Keyword(s):  
Method Comparison ◽  
Therapy Response ◽  
Reference Intervals ◽  
Light Chains ◽  
Reference Ranges ◽  
Free Light Chains ◽  
Monoclonal Gammopathies ◽  
Serum Free Light Chain ◽  
Roche Diagnostics ◽  
Roche Cobas

Abstract Objectives Free light chains (FLC) are important in the diagnosis, prognosis and monitoring of therapy response of patients with monoclonal gammopathies. In this study, we performed a method comparison of three FLC assays on the Cobas 6000 c501 chemistry analyzer of Roche Diagnostics. Methods Samples of 119 patients with various monoclonal gammopathies and 26 control patients were measured with the Freelite (The Binding Site), Diazyme (Diazyme Laboratories) and KLoneus (Trimero Diagnostics) FLC assays. A method comparison was performed and reference intervals of the three assays were validated. Results The analysis of the Bland-Altman agreement showed bias between the three FLC assays, ranging from −62.7 to 5.1% for κFLC and between −29.2 to 80.5% for λFLC. The Freelite and Diazyme assays have the highest agreement. The concordance of the FLC-ratio ranges from 41 to 75%, with the highest concordance between the Freelite and KLoneus assays. The FLC-ratio in 25 sera from healthy controls were within the reference ranges of the Freelite and KLoneus assays. The FLC-ratio was elevated in all 25 samples tested with the Diazyme assay. Conclusions The agreement for the free light chains is highest between the Freelite and the Diazyme assay and fair for the KLoneus assay. However, concordance of the FLC-ratio is highest when the Freelite and KLoneus assays were compared. Our data suggest that concordance for the Diazyme assay could be improved by recalibration. Because of absolute differences between the three methods in individual patients, none of the three FLC assays can be used interchangeably.

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