Total protein measurement in canine cerebrospinal fluid: agreement between a turbidimetric assay and 2 dye-binding methods and determination of reference intervals using an indirect a posteriori method

2014 ◽  
Vol 43 (1) ◽  
pp. 78-88 ◽  
Author(s):  
B. Riond ◽  
F. Steffen ◽  
O. Schmied ◽  
R. Hofmann-Lehmann ◽  
H. Lutz
Keyword(s):  
Cerebrospinal Fluid ◽  
Total Protein ◽  
Reference Intervals ◽  
A Posteriori ◽  
Dye Binding ◽  
Turbidimetric Assay ◽  
Total Protein Measurement ◽  
Protein Measurement

scholarly journals Calcium, Magnesium, Albumin, and Total Protein Measurement in Serum as Assessed with 20 Fresh-Frozen Single-Donation Sera

2012 ◽  
Vol 58 (11) ◽  
pp. 1597-1599 ◽  
Author(s):  
Sofie K Van Houcke ◽  
Pål Rustad ◽  
Hedwig CM Stepman ◽  
Gunn BB Kristensen ◽  
Dietmar Stöckl ◽  
...  
Keyword(s):  
Total Protein ◽  
Fresh Frozen ◽  
Calcium Magnesium ◽  
Total Protein Measurement ◽  
Protein Measurement

Sulfasalazine interference in total protein measurement on the Beckman CX7

1993 ◽  
Vol 39 (9) ◽  
pp. 2028-2028 ◽  
Author(s):  
S Muir ◽  
P Turner ◽  
V O'Toole ◽  
T C Badrick
Keyword(s):  
Total Protein ◽  
Total Protein Measurement ◽  
Protein Measurement

Multicommutated flow analysis system for determination of total protein in cerebrospinal fluid

Talanta ◽  
2014 ◽  
Vol 128 ◽  
pp. 38-43 ◽  
Author(s):  
Kamil Strzelak ◽  
Agnieszka Wiśniewska ◽  
Dagna Bobilewicz ◽  
Robert Koncki
Keyword(s):  
Cerebrospinal Fluid ◽  
Total Protein ◽  
Flow Analysis ◽  
Analysis System

scholarly journals Cerebrospinal Fluid Total Protein Reference Intervals Derived from 20 Years of Patient Data

2017 ◽  
Vol 63 (12) ◽  
pp. 1856-1865 ◽  
Author(s):  
Christopher R McCudden ◽  
John Brooks ◽  
Priya Figurado ◽  
Pierre R Bourque
Keyword(s):  
Cerebrospinal Fluid ◽  
Quantile Regression ◽  
Total Protein ◽  
Blood Cells ◽  
White Blood Cells ◽  
Age Groups ◽  
Reference Intervals ◽  
Patient Data ◽  
Age Dependence ◽  
Data Set

Abstract BACKGROUND Reference intervals are vital for interpretation of laboratory results. Many existing reference intervals for cerebrospinal fluid total protein (CSF-TP) are derived from old literature because of the invasive nature of sampling. The objective of this study was to determine reference intervals for CSF-TP using available patient data. METHODS Twenty years of hospital database information was mined for previously reported CSF-TP results. Associated demographic, laboratory, and clinical diagnosis (International Classification of Diseases 9/10 codes) details were extracted. CSF-TP results included 3 different analytical platforms: the Siemens Vista 1500, Beckman Lx20, and Roche Hitachi 917. From an initial data set of 19591 samples, the following exclusion criteria were applied: incomplete data, white blood cells (WBCs) >5 × 106/L, red blood cells (RBCs) >50 × 106/L, and glucose <2.5 mmol/L. Patient charts were reviewed in detail to exclude 60 different conditions for which increases in CSF-TP would be expected. A total of 6068 samples were included; 63% of the samples were from females. Continuous reference intervals were determined using quantile regression. Age- and sex-partitioned intervals were established using the quantile regression equation and splitting age-groups into 5-year bins. RESULTS CSF-TP showed a marked age dependence, and males had significantly higher CSF-TP than females across all ages. CSF-TP results from the 3 different instruments and manufacturers showed small (approximately 0.04 g/L), but statistically significant, differences. CSF-TP showed weak, but again statistically significant, correlation with WBC and RBC but was independent of serum total protein and creatinine. CONCLUSIONS The age dependence of CSF-TP supports that age-partitioned reference intervals will be more accurate than a single cutoff, particularly in patients with advancing age.

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