Outcome of Dogs with Bone Marrow Suppression Secondary to Sertoli Cell Tumor

2021 ◽  
Author(s):  
Sarah A. Salyer ◽  
Janis M. Lapsley ◽  
Carrie A. Palm ◽  
William T. N. Culp ◽  
Alycen P. Lundberg ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Sertoli Cell ◽  
Bone Marrow Suppression ◽  
Cell Tumor ◽  
Sertoli Cell Tumor

scholarly journals Intra-abdominal Sertoli Cell Tumor in Dog with Local and Systemic Repercussions

2018 ◽  
Vol 46 ◽  
pp. 7
Author(s):  
Mirlla Baracho Ferreira ◽  
Keylla Suellen Batalha Rocha Feranandes ◽  
Alessandra Moreira Da Silva ◽  
Kayana Cunha Marques ◽  
Brizza Zorayd Luz Lopes Rocha ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Testicular Cancer ◽  
Malignant Transformation ◽  
Sertoli Cell ◽  
Abdominal Mass ◽  
Cell Tumor ◽  
Sertoli Cell Tumor ◽  
Left Testis ◽  
Bone Marrow Hypoplasia ◽  
Adjacent Structures

Background: In dogs, abdominal testes have higher risk of malignant transformation, and the Sertoli cell tumor is the most common type of testicular cancer in the species. This neoplasia can lead to an increase on estrogen production, causing a paraneoplastic feminization syndrome with dermatologic, behavioral and blood repercussions. When located inside theabdomen, the Sertoli cell tumor can compress adjacent organs, worsening the prognosis. Thus, this study aimed to report a case of an intra-abdominal Sertoli cell tumor in a dog associated to multiple organic complications.Case: A 4-year-old male Shih-tzu was admitted at the Veterinary Hospital of Universidade Federal Rural do Semi-Árido (UFERSA), with a history of abdominal cryptorchidism and the development of dermatological signs, such as alopecia and hyperpigmentation, with an evolution of two months. At physical examination it was observed alopecia on lumbosacral regionand on hind limbs, hyperpigmentation, gynecomastia and pendulous prepuce, suggestive of feminization syndrome. A firm mass was palpated on caudal abdomen. The following exams were requested: complete blood cell count, serum biochemistry (alanine aminotransferase, alkaline phosphatase, creatinine and urea), abdominal ultrasonography and fine needle aspiration cytology of the abdominal mass. Hematological and biochemistry profile were within the normal range for the species. Onthe ultrasonography, regular and rounded structures were observed, suggesting ectopic testes (left testis: 2.37 x 2.95 cm; right testis: 1.92 x 1.38 cm). The left testis presented characteristics of malignant transformation. The cytology of the abdominal mass suggested Sertoli cell tumor. The dog was submitted to an exploratory laparotomy. The right testis was atrophied and its orchiectomy was performed. The contralateral testis was completed adhered to great vessels, such as abdominal aorta and caudal vena cava, and also to adjacent viscera. Thus, the exeresis of the tumor was not possible and fragments of the mass were collected and referred to histopathology. The left testicle presented tumoral polyedric cells, alonged at the longitudinal axis, propagating disorderly, and with central rounded nucleus, and a clear and vacuolar cytoplasm. It was alsoobserved desmoplasia, anisocytosis, anisocariasis, nuclear atypia and evident nucleoli. The mitotic index was less than one mitotic figure/40x, with aberrant mitotic figures. The histopathological evaluation was compatible with Sertoli cell tumor, confirming the presumptive diagnosis. Chemotherapy was proposed, but the animal’s owner refused. After four months the dog was readmitted presenting a series of complications due to the tumor growth, including bone marrow hypoplasia, gallbladder compression and hydronephrosis. Because of the poor prognosis and severity of complications a decision to euthanize the animal was made.Discussion: Intra-abdominal Sertoli cell tumors have good prognosis when the diagnosis and surgical treatment are made early. Nevertheless, this neoplasia can be associated to critical and irreversible damages to various organs, such as bone marrow hypoplasia, and compression of abdominal organs when the tumor grows rapidly and invades adjacent structures,making the complete surgical exeresis impossible. Therefore, the orchiectomy of cryptorchidic dogs is recommended as soon as possible to prevent the development of testicular cancer in these animals.Keywords: cryptorchidism, testicular neoplasia, Canis lupus familiaris.

scholarly journals Bone marrow bi-hypoplasia in a dog with a sertoli cell tumor

2017 ◽  
Vol 69 (1) ◽  
pp. 95-100
Author(s):  
P.C.L.G. Valente ◽  
R.M. Couto ◽  
C.O. Gamba ◽  
A.V. Vasconcelos ◽  
F.O.P. Leme ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Sertoli Cell ◽  
Complete Blood Count ◽  
Cell Tumor ◽  
Severe Thrombocytopenia ◽  
Sertoli Cell Tumor ◽  
Erythroid Precursor ◽  
Molecular Tests ◽  
Bone Marrow Hypoplasia ◽  
Hemostatic Disorders

ABSTRACT A 20-year-old unneutered male poodle presented prostration, apathy, staggering gait, lack of appetite and tick infestation. The dog was diagnosed with a Sertoli cell tumor in an undescended testicle by cytological, histopathological and immunohistochemical tests. Pancytopenia with moderate nonregenerative anemia, leukopenia and severe thrombocytopenia were detected in the complete blood count. Cytological and histopathological evaluation of the bone marrow revealed a cellularity of 30%, with erythroid (59%), lymphoid (40%) and mast cells (1%), and an absence of granulocytic, monocytic and megakaryocytic lineage cells. In post-mortem examinations, changes related to hemostatic disorders were found. The absence of microorganisms in molecular tests and an estrogen serum concentration over reference values confirmed hyperestrogenism as a possible cause of pancytopenia. The literature describes a Sertoli cell tumor hyperestrogenism that induced pancytopenia, along with bone marrow hypoplasia of all hematopoietic lineages. In contrast, in the present case, the erythroid precursor cells were preserved in the bone marrow, although there were no reticulocytes circulating in the blood. This case, therefore, should be considered in future investigations of pancytopenia induced by Sertoli cell tumor hyperestrogenism.

Inoperable Ovarian Sertoli Cell Tumor in an Elderly Patient, Case Report and Review of Literature

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Bedoudou H ◽  
Aboueljaoud B ◽  
Mai A ◽  
Banani A ◽  
Alaoui Lamrani Y ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Case Report ◽  
Sertoli Cell ◽  
Cell Tumor ◽  
Review Of Literature ◽  
Sertoli Cell Tumor ◽  
Patient Case

Testicular Tumors—Some New and a Few Perennial Problems

2008 ◽  
Vol 132 (4) ◽  
pp. 548-564 ◽  
Author(s):  
Robert H. Young
Keyword(s):  
Germ Cell ◽  
Sertoli Cell ◽  
Leydig Cell ◽  
Yolk Sac ◽  
Cell Tumor ◽  
Yolk Sac Tumor ◽  
Female Gonad ◽  
Sertoli Cell Tumor ◽  
Older Patient ◽  
Testicular Tumors

Abstract The histopathology of testicular tumors is presented, emphasizing new, unusual, or underemphasized aspects. Within the category of seminoma of the usual type, the recent literature has drawn attention to the presence in occasional tumors of solid or hollow tubules or spaces of varying sizes and shape that may result in cribriform or microcystic patterns, causing potential confusion with other neoplasms, most notably Sertoli cell tumor or yolk sac tumor. Although regions of typical neoplasia and awareness of this phenomenon usually will be diagnostic, immunohistochemistry may play a role in excluding Sertoli cell tumor or yolk sac tumor. Although immunohistochemistry can play an undoubted helpful role in this and selected other areas of testicular tumor evaluation, careful evaluation of the gross and routine microscopic features will solve the vast majority of diagnostic problems. An excellent review of immunohistochemistry in this area by R. E. Emerson, MD, and T. M. Ulbright, MD, is cited herein. Spermatocytic seminoma remains a crucial pitfall in diagnosis, and the pathologist must always be alert to the possible diagnosis when looking at a seminomatous neoplasm, particularly in an older patient, although about one third of these tumors occur in the usual seminoma age range. The embryonal carcinoma has a great diversity of patterns, which are briefly noted. The enigmatic and picturesque tumor, polyembryoma, which virtually never occurs in pure form but may be a confusing component of a variety of mixed germ cell tumors, is discussed and illustrated. The phenomenon of burnt-out germ cell neoplasia is also briefly noted and an excellent recent contribution is referred to. Within the sex cord–stromal family of neoplasms, recent contributions and elaborations of unusual morphologic features of Leydig cell tumors and Sertoli cell tumors are presented. Within the Leydig cell family, cyst formation, adipose metaplasia, calcification or ossification, and spindle cell patterns may be particularly confusing, and in the Sertoli cell family, a great array of patterns caused by differing admixtures of tubular, solid, and stromal components occur. The peculiar lesion, intratubular large cell hyalinizing Sertoli cell tumor, of young boys with Peutz-Jeghers syndrome, is briefly discussed. Some of the problems in the family of hematopoietic neoplasms are reviewed, these processes posing diverse problems in differential diagnosis and their correct recognition having crucial therapeutic implications. Although secondary tumors to the testis have not received the same attention in the literature as the similar phenomenon in the female gonad, remarkable examples of testicular spread of diverse neoplasms, usually carcinoma but rarely melanoma, are seen, and the pathologist should be alert to this possibility, particularly when examining an unusual morphology in an older patient. Finally, a few comments are made on the common paratesticular neoplasm, the adenomatoid tumor, highlighting its varied patterns and recent description of some of the issues that may arise when they undergo total or subtotal infarction.

Sertoli Cell Tumor

2022 ◽  
pp. 1349-1354
Author(s):  
Cynthia M. Faux ◽  
Marcie L. Logsdon
Keyword(s):  
Sertoli Cell ◽  
Cell Tumor ◽  
Sertoli Cell Tumor

NSE positive Sertoli cell tumor of the testis: case report and literature review

2020 ◽  
Vol 216 (8) ◽  
pp. 152990
Author(s):  
Gregor Mikuz ◽  
Elisabeth Wadl ◽  
Pavlos Raptis ◽  
Klaus Jeschke ◽  
Hermann Rogatsch
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Sertoli Cell ◽  
Cell Tumor ◽  
Sertoli Cell Tumor
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