Atorvastatin preferentially inhibits the growth of high ZEB ‐expressing canine cancer cells

2021 ◽  
Author(s):  
Takuro Ishikawa ◽  
Tomohiro Osaki ◽  
Akihiro Sugiura ◽  
Jiro Tashiro ◽  
Tomoko Warita ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Canine Cancer

scholarly journals Comprehensive Live-cell Imaging Analysis of Cryptotanshinone and Synergistic Drug-Screening Effects in Various Human and Canine Cancer Cell Lines

2020 ◽  
Author(s):  
Michael L. Bittner ◽  
Rosana Lopes ◽  
Jianping Hua ◽  
Chao Sima ◽  
Aniruddha Datta ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Drug Screening ◽  
Drug Exposure ◽  
Salvia Miltiorrhiza ◽  
Cancer Cell Lines ◽  
Drug Combinations ◽  
Live Cell ◽  
Canine Cancer

ABSTRACTBackgroundSeveral studies have highlighted both the extreme anticancer effects of Cryptotanshinone (CT), a Stat3 crippling component from Salvia miltiorrhiza, as well as other STAT3 inhibitors to fight cancer.MethodsData presented in this experiment incorporates 2 years of in vitro studies applying a comprehensive live-cell drug-screening analysis of human and canine cancer cells exposed to CT at 20 μM concentration, as well as to other drug combinations. As previously observed in other studies, dogs are natural cancer models, given to their similarity in cancer genetics, epidemiology and disease progression compared to humans.ResultsResults obtained from several types of human and canine cancer cells exposed to CT and varied drug combinations, verified CT efficacy at combating cancer by achieving an extremely high percentage of apoptosis within 24 hours of drug exposure.ConclusionsCT anticancer efficacy in various human and canine cancer cell lines denotes its ability to interact across different biological processes and cancer regulatory cell networks, driving inhibition of cancer cell survival.

scholarly journals Cell line-specific efficacy of thermoradiotherapy in human and canine cancer cells in vitro

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216744 ◽  
Author(s):  
Katarzyna J. Nytko ◽  
Pauline Thumser-Henner ◽  
Mathias S. Weyland ◽  
Stephan Scheidegger ◽  
Carla Rohrer Bley
Keyword(s):  
Cancer Cells ◽  
Cell Line ◽  
Canine Cancer

scholarly journals Cytotoxic Effects of Loperamide Hydrochloride on Canine Cancer Cells

2014 ◽  
Vol 76 (12) ◽  
pp. 1563-1568 ◽  
Author(s):  
Rebecca Cohen REGAN ◽  
Robert Michael GOGAL Jr ◽  
James Perry BARBER ◽  
Richard Cary TUCKFIELD ◽  
Elizabeth Wynne HOWERTH ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cytotoxic Effects ◽  
Canine Cancer

Inhibition of telomerase in canine cancer cells following telomestatin treatment

2007 ◽  
Vol 5 (2) ◽  
pp. 99-107 ◽  
Author(s):  
S. Long ◽  
D. J. Argyle ◽  
E. A. Gault ◽  
L. Nasir
Keyword(s):  
Cancer Cells ◽  
Canine Cancer

scholarly journals Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells

2019 ◽  
Author(s):  
Yousef Alharbi ◽  
Arvinder Kapur ◽  
Mildred Felder ◽  
Lisa Barroilhet ◽  
Timothy Stein ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Cells ◽  
Oxygen Radicals ◽  
Outward Current ◽  
Radical Scavenger ◽  
Cancer Therapies ◽  
Drug Induced ◽  
Whole Cell Patch Clamp ◽  
Short Term Exposure ◽  
Canine Cancer

AbstractThe Na+/K+-ATPase (NKA) complex is the master regulator of membrane potential and a target for anti-cancer therapies. Here, we investigate the effect of drug-induced oxidative stress on NKA activity. The natural product, plumbagin increases oxygen radicals through inhibition of oxidative phosphorylation. As a result, plumbagin treatment results in decreased production of ATP and a rapid increase in intracellular oxygen radicals. We show that plumbagin induces apoptosis in canine cancer cells via oxidative stress. We use this model to test the effect of oxidative stress on NKA activity. Using whole-cell patch-clamp electrophysiology we demonstrate that short-term exposure (4 min) to plumbagin results in 48% decrease in outward current at +50 mV. Even when exogenous ATP was supplied to the cells, plumbagin treatment resulted in 46% inhibition outward current through NKA at +50 mV. In contrast, when the canine cancer cells were pre-treated with the oxygen radical scavenger, N-acetylcysteine, the NKA inhibitory activity of plumbagin was abrogated. These experiments demonstrate that the oxidative stress-causing agents such as plumbagin and its analogues, are a novel avenue to regulate NKA activity in tumors.

scholarly journals Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yousef Alharbi ◽  
Arvinder Kapur ◽  
Mildred Felder ◽  
Lisa Barroilhet ◽  
Timothy Stein ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Cells ◽  
Canine Cancer
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