scholarly journals Extensive staging has no prognostic value in dogs with low‐risk mast cell tumors

2021 ◽  
Author(s):  
Csilla Fejös ◽  
Karin Troedson ◽  
Nataliia Ignatenko ◽  
Yury Zablotski ◽  
Johannes Hirschberger
Keyword(s):  
Mast Cell ◽  
Prognostic Value ◽  
Low Risk ◽  
Mast Cell Tumors

scholarly journals Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors

2021 ◽  
pp. 030098582098513
Author(s):  
Mafalda Casanova ◽  
Sandra Branco ◽  
Inês Berenguer Veiga ◽  
André Barros ◽  
Pedro Faísca
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Prognostic Value ◽  
Histological Grade ◽  
Intraobserver Variability ◽  
Low Grade ◽  
High Grade ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell ◽  
Grade Iii

Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume ([Formula: see text]), a stereological estimation that provides information about nuclear size and its variability. [Formula: see text] of 55 ccMCTs was estimated using the “point-sampled intercept” method and compared with histological grade and clinical outcome. The clinical history of dogs treated with surgical excision alone was available for 30 ccMCTs. Statistical differences in [Formula: see text] were found between grade II ([Formula: see text]= 115 ± 29 µm3) and grade III ccMCTs ([Formula: see text]= 197 ± 63 µm3), as well as between low-grade ([Formula: see text]= 113 ± 28 µm3) and high-grade ccMCTs ([Formula: see text]= 184 ± 63 µm3). An optimal cutoff value of [Formula: see text] ≥ 150 µm3 and [Formula: see text] ≥ 140 µm3 was determined for grade III and high-grade ccMCTs, respectively. In terms of prognosis, [Formula: see text] was not able to predict the clinical outcome in 42% of the cases; however, cases with [Formula: see text]<125 µm3 had a favorable outcome. These results indicate that, despite having limited prognostic value when used as a solitary parameter, [Formula: see text] is highly reproducible and is associated with histological grade as well as with benign behavior.

Internal Tandem Duplication of Exon 8 of c-kit Is Associated With Longer Total Survival in Canine Cutaneous Mast Cell Tumors

2020 ◽  
pp. 030098582097346
Author(s):  
Bouvien A. W. Brocks ◽  
Christof A. Bertram ◽  
Alexander Bartel ◽  
Jolle Kirpensteijn ◽  
Alexandra Collins-Webb ◽  
...  
Keyword(s):  
Mast Cell ◽  
Poor Prognosis ◽  
Prognostic Value ◽  
Cellular Proliferation ◽  
Biological Behavior ◽  
Kit Mutation ◽  
Mast Cell Tumors ◽  
Mutational Status ◽  
Cutaneous Mast Cell ◽  
Exon 11

Canine cutaneous mast cell tumors (ccMCTs) have a highly variable biological behavior and accurate prognostication is essential for therapeutic intervention. Internal tandem duplications (ITD) of exon 11 are the most commonly detected c-kit mutation in ccMCTs and are associated with poor prognosis and increased cellular proliferation. The prognostic value of detecting mutations in other exons of c-kit has not been systematically examined. In this study, we analyzed the prognostic value of ITD mutations of exon 8 in c-kit of ccMCTs in comparison to ccMCTs with ITD mutations of exon 11 and ccMCTs without mutations of exon 8 or 11. The mutational status, histological grade, KIT expression pattern, Ki67 index, AgNOR (argyrophilic nucleolar organizing region) score, and Ag67 score were determined in 221 ccMCTs, and outcome was available for 101 dogs. ITD mutations of exon 8 were found in 73/221 (33%), of exon 11 in 100/221 (45%), and none of these mutations in 50/221 (22%) of ccMCTs. None of the dogs with mutations of exon 8 died due to suspected ccMCT-related cause, but 23% dogs with ccMCTs with mutations of exon 11 died due to suspected ccMCT-related cause. Prognostic parameters in ccMCTs with exon 11 mutations were commonly associated with a high proliferative activity and poor prognosis, while prognostic markers in ccMCTs with mutations of exon 8 had lower values similar to those observed in ccMCTs without mutations in exons 8 or 11 of c-kit. This study indicates that screening for ITD mutations in exon 8 in ccMCTs may be helpful to identify less aggressive ccMCTs and may be recommended as a supplementary prognostic test.

Immunohistochemical Expression of Vascular Endothelial Growth Factor as a Prognostic Marker for Canine Mast Cell Tumors

2021 ◽  
Vol 42 ◽  
pp. 100506
Author(s):  
Samanta Rios Melo ◽  
Eric Vieira Januário ◽  
Erika Zanuto ◽  
Bruna de Castro Miranda ◽  
Thais Rodrigues Macedo ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Mast Cell ◽  
Growth Factor ◽  
Prognostic Marker ◽  
Vascular Endothelial ◽  
Immunohistochemical Expression ◽  
Mast Cell Tumors ◽  
Endothelial Growth Factor

Correlation of histologic grading of canine mast cell tumors with Ki67/PCNA/AgNOR/c-Kit scores: 38 cases (2002-2003)

2004 ◽  
Vol 2 (2) ◽  
pp. 98-98 ◽  
Author(s):  
P. J. Bergman ◽  
D. M. Craft ◽  
S. J. Newman ◽  
K. Baer ◽  
M. A. Camps-Palau ◽  
...  
Keyword(s):  
Mast Cell ◽  
Histologic Grading ◽  
Mast Cell Tumors

scholarly journals Cutaneous Tumors in Swiss Dogs: Retrospective Data From the Swiss Canine Cancer Registry, 2008–2013

2018 ◽  
Vol 55 (6) ◽  
pp. 809-820 ◽  
Author(s):  
Ramona Graf ◽  
Andreas Pospischil ◽  
Franco Guscetti ◽  
Daniela Meier ◽  
Monika Welle ◽  
...  
Keyword(s):  
Mast Cell ◽  
Nova Scotia ◽  
Cancer Registry ◽  
Soft Tissue Sarcomas ◽  
Population Data ◽  
Cancer Registries ◽  
Mast Cell Tumors ◽  
Melanocytic Tumors ◽  
Canine Cancer ◽  
Tumor Types

Data collected in animal cancer registries comprise extensive and valuable information, even more so when evaluated in context with precise population data. The authors evaluated 11 740 canine skin tumors collected in the Swiss Canine Cancer Registry from 2008–2013, considering data on breed, sex, age, and anatomic locations. Their incidence rate (IR) per 100 000 dogs/year in the Swiss dog population was calculated based on data from the official and mandatory Swiss dog registration database ANIS. The most common tumor types were mast cell tumors (16.35%; IR, 60.3), lipomas (12.47%; IR, 46.0), hair follicle tumors (12.34%; IR, 45.5), histiocytomas (12.10%; IR, 44.6), soft tissue sarcomas (10.86%; IR, 40.1), and melanocytic tumors (8.63%; IR, 31.8) with >1000 tumors per type. The average IR of all tumor types across the 227 registered breeds was 372.2. The highest tumor incidence was found in the Giant Schnauzer (IR, 1616.3), the Standard Schnauzer (IR, 1545.4), the Magyar Vizsla (IR, 1534.6), the Rhodesian Ridgeback (IR, 1445.0), the Nova Scotia Duck Tolling Retriever (IR, 1351.7), and the Boxer (IR, 1350.0). Mixed-breed dogs (IR, 979.4) had an increased IR compared to the average of all breeds. Previously reported breed predispositions for most tumor types were confirmed. Nevertheless, the data also showed an increased IR for mast cell tumors and melanocytic tumors in the Nova Scotia Duck Tolling Retriever and for histiocytomas in the Flat Coated Retriever. The results from this study can be taken into consideration when selecting purebred dogs for breeding to improve a breed’s health.

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