Evaluation of a modified proportional margin approach for complete surgical excision of canine cutaneous mast cell tumours and its association with clinical outcome

2020 ◽  
Author(s):  
Harvey Saunders ◽  
Maurine J. Thomson ◽  
Kathleen O'Connell ◽  
Janis P. Bridges ◽  
Lincoln Chau
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Surgical Excision ◽  
Complete Surgical Excision ◽  
Cutaneous Mast Cell

Recurrence Rates and Sites for Grade II Canine Cutaneous Mast Cell Tumors Following Complete Surgical Excision

2002 ◽  
Vol 38 (1) ◽  
pp. 71-73 ◽  
Author(s):  
Chick Weisse ◽  
Frances S. Shofer ◽  
Karin Sorenmo
Keyword(s):  
Mast Cell ◽  
Tumor Recurrence ◽  
Surgical Excision ◽  
Adjuvant Radiation ◽  
Recurrence Rates ◽  
Mast Cell Tumors ◽  
Complete Surgical Excision ◽  
Grade Ii ◽  
Cutaneous Mast Cell ◽  
Distant Tumor

A retrospective study was performed on 31 dogs with completely excised, grade II, cutaneous mast cell tumors in order to determine recurrence rates and sites. Distant tumor recurrence developed in 22% of dogs, and local tumor recurrence developed in 11% of dogs; however, the vast majority of these animals were incompletely staged initially. Complete surgical excision of grade II mast cell tumors was associated with effective local control in 89% of these dogs. Therefore, adjuvant radiation therapy might not be indicated in the majority of dogs with complete surgical excision.

scholarly journals Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors

2021 ◽  
pp. 030098582098513
Author(s):  
Mafalda Casanova ◽  
Sandra Branco ◽  
Inês Berenguer Veiga ◽  
André Barros ◽  
Pedro Faísca
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Prognostic Value ◽  
Histological Grade ◽  
Intraobserver Variability ◽  
Low Grade ◽  
High Grade ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell ◽  
Grade Iii

Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume ([Formula: see text]), a stereological estimation that provides information about nuclear size and its variability. [Formula: see text] of 55 ccMCTs was estimated using the “point-sampled intercept” method and compared with histological grade and clinical outcome. The clinical history of dogs treated with surgical excision alone was available for 30 ccMCTs. Statistical differences in [Formula: see text] were found between grade II ([Formula: see text]= 115 ± 29 µm3) and grade III ccMCTs ([Formula: see text]= 197 ± 63 µm3), as well as between low-grade ([Formula: see text]= 113 ± 28 µm3) and high-grade ccMCTs ([Formula: see text]= 184 ± 63 µm3). An optimal cutoff value of [Formula: see text] ≥ 150 µm3 and [Formula: see text] ≥ 140 µm3 was determined for grade III and high-grade ccMCTs, respectively. In terms of prognosis, [Formula: see text] was not able to predict the clinical outcome in 42% of the cases; however, cases with [Formula: see text]<125 µm3 had a favorable outcome. These results indicate that, despite having limited prognostic value when used as a solitary parameter, [Formula: see text] is highly reproducible and is associated with histological grade as well as with benign behavior.

Periocular cutaneous mast cell tumors in cats: evaluation of surgical excision (33 cases)

2010 ◽  
Vol 13 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Keith W. Montgomery ◽  
Alexandra van der Woerdt ◽  
Susette M. Aquino ◽  
John S. Sapienza ◽  
Eric C. Ledbetter
Keyword(s):  
Mast Cell ◽  
Surgical Excision ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell

Cutaneous mast cell tumors in cats: 32 cases (1991-1994)

1998 ◽  
Vol 34 (4) ◽  
pp. 281-284 ◽  
Author(s):  
H Molander-McCrary ◽  
CJ Henry ◽  
K Potter ◽  
JW Tyler ◽  
MS Buss
Keyword(s):  
Mast Cell ◽  
Tumor Recurrence ◽  
Patient Survival ◽  
Prognostic Significance ◽  
Surgical Excision ◽  
Recurrence Rates ◽  
Histopathological Grade ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell ◽  
Patient Survival Time

Case records of 32 cats with cutaneous mast cell tumors (CMCTs) were reviewed. Using the Patnaik system for grading canine mast cell tumors, the relationships between histopathological grade and patient survival time and tumor recurrence were examined. Tumor histopathological grade had no prognostic significance. One-, two-, and three-year tumor recurrence rates following surgical excision were 16%, 19%, and 13%, respectively. Incomplete excision was not associated with a higher rate of tumor recurrence.

scholarly journals Grading Cutaneous Mast Cell Tumors in Cats

2018 ◽  
Vol 56 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Silvia Sabattini ◽  
Giuliano Bettini
Keyword(s):  
Mast Cell ◽  
Case Series ◽  
Surgical Excision ◽  
Skin Neoplasms ◽  
Grading System ◽  
Low Grade ◽  
Tumor Diameter ◽  
High Grade ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell

Cutaneous mast cell tumors (cMCTs) account for approximately 20% of skin neoplasms in cats. As there is no grading system for these tumors, prognosis is difficult to estimate. Although the typical presentation is a benign tumor that can be cured by surgical excision, a small but important proportion of feline cMCTs is biologically aggressive and can spread to local lymph nodes, precede the onset of disseminated cutaneous disease, or be associated with visceral involvement. A number of macroscopic and histologic features were retrospectively evaluated in cases of feline cMCTs treated with surgical excision with or without medical therapy. Cats were divided into 2 groups based on the clinical outcome. Group 1 included cats alive with no mast cell tumor–related disease at 1000 days from surgery; group 2 included cats developing histologically confirmed metastatic or cutaneous disseminated disease. The criteria allowing the best differentiation between the groups were used to develop a grading scheme. Groups 1 and 2 were composed by 48 (76%) and 15 (24%) cases, respectively. Tumors were classified as high grade if there were >5 mitotic figures in 10 fields (400×) and at least 2 of the following criteria: tumor diameter >1.5 cm, irregular nuclear shape, and nucleolar prominence/chromatin clusters. According to this scheme, the 15 (24%) high-grade cMCTs had significantly reduced survival time (median, 349 days; 95% CI, 0–739 days) as compared with the 48 low-grade tumors (median not reached; P < .001). Further studies are warranted to validate this grading system and test reproducibility on a larger case series.

scholarly journals Genomic copy number variation associated with clinical outcome in canine cutaneous mast cell tumors

2017 ◽  
Vol 111 ◽  
pp. 26-30 ◽  
Author(s):  
Paulo C Jark ◽  
Deborah B.P. Mundin ◽  
Marcio de Carvalho ◽  
Raquel B. Ferioli ◽  
Letícia A Anai ◽  
...  
Keyword(s):  
Mast Cell ◽  
Clinical Outcome ◽  
Copy Number Variation ◽  
Copy Number ◽  
Genomic Copy Number ◽  
Mast Cell Tumors ◽  
Genomic Copy ◽  
Number Variation ◽  
Cutaneous Mast Cell ◽  
Genomic Copy Number Variation

Prognosis Following Surgical Excision of Canine Cutaneous Mast Cell Tumors With Histopathologically Tumor-Free Versus Nontumor-Free Margins: A Retrospective Study of 31 Cases

2002 ◽  
Vol 38 (5) ◽  
pp. 458-466 ◽  
Author(s):  
Gina M. Michels ◽  
Deborah W. Knapp ◽  
Dennis B. DeNicola ◽  
Nita Glickman ◽  
Patty Bonney
Keyword(s):  
Mast Cell ◽  
Retrospective Study ◽  
Small Sample Size ◽  
Surgical Excision ◽  
Local Relapse ◽  
Small Sample ◽  
Mast Cell Tumors ◽  
Statistical Support ◽  
Cutaneous Mast Cell ◽  
Tumor Related Death

The purpose of this study was to determine if the presence of histopathologically tumor-free versus nontumor-free margins was prognostic for relapse or tumor-related death in dogs following surgical excision of single or multiple cutaneous mast cell tumors confined to the skin without evidence of metastasis to lymph nodes or other noncutaneous sites. Differences in tumor-related death or frequency of relapse between the two groups were not significant. Failure to achieve histopathological tumor-free margins frequently did not lead to local relapse. All tumor-related deaths occurred following local relapse. The lack of statistical support for an association between prognosis and histopathological tumor-free versus nontumor-free margins may be a result of small sample size.

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