Impact of radiation dose and pre‐treatment pain levels on survival in dogs undergoing radiotherapy with or without chemotherapy for presumed extremity osteosarcoma

2020 ◽  
Vol 18 (4) ◽  
pp. 538-547
Author(s):  
Michael W. Nolan ◽  
Noah A. Green ◽  
Elizabeth M. DiVito ◽  
B. Duncan X. Lascelles ◽  
Siobhan M. Haney
Keyword(s):  
Radiation Dose ◽  
Pre Treatment ◽  
Extremity Osteosarcoma

Abstract WMP119: 4d Digital Subtraction Angiography (4d-dsa) for Pre-treatment Evaluation of Cerebrovascular Diseases

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Ichiro Yuki ◽  
Shunsuke Hataoka ◽  
Toshihiro Ishibashi ◽  
Chihebeddine Dahmani ◽  
Yukiko Abe ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Digital Subtraction Angiography ◽  
Treatment Planning ◽  
Vascular Malformation ◽  
Vascular Malformations ◽  
Cerebrovascular Diseases ◽  
Acquisition Time ◽  
Digital Subtraction ◽  
Vascular Structures ◽  
Pre Treatment

Purpose: 4D Digital Subtraction Angiography (4D-DSA) is a new imaging technology that provides both high spatial resolution and temporal resolution in one acquisition. It is a special new reconstruction algorithm that made this technology possible. Patients with various types of cerebrovascular diseases were evaluated with 4D-DSA, and its efficacy and limitations were assessed. Methods: The 4D-DSA images of patients with different types of vascular malformations were evaluated. 6 seconds acquisitions were used for the evaluation of arterial phase dynamics and 12 seconds acquisitions for assessing the entire arterial-venous phase. The amount of contrast material and radiation dose used in each acquisition was compared with the conventional rotational 3D-DSA. The unique findings observed in the 4D-DSA in each type of vascular malformation were described, and whether or not the findings are useful for the pre-treatment planning was discussed. Results: The 4D-DSA images of a total of 57 patients were evaluated. 33 aneurysm patients, 6 arteriovenous malformation (AVM) patients, 8 dural arteriovenous fistula (AVF) patients, as well as 4 spinal vascular malformation patients, and 6 others were included. The amount of contrast and radiation dose required for the 4D-DSA (6 seconds acquisition) was similar to the conventional 3D-DSA, whereas 12 seconds acquisitions required almost double the dose. Especially for the vascular malformations with arterio-venous shunting, the 4D-DSA helped understand the detailed vascular anatomy by breaking down the complex vascular structures into the different phases of contrast filling. Motion artifact due to the longer acquisition time, and metal artifact from deployed coils were observed. Conclusions: The temporal information provided by 4D-DSA helps us understand the complex vascular structures and flow dynamics. 4D-DSA can be an effective assessment tool for the pre-treatment planning of brain vascular malformations.

A province-wide retrospective comparison of pathologic response and progression-free survival in locally advanced esophagus cancer patients treated with either cisplatin-5FU (CF) or carboplatin-paclitaxel (CP) concurrent with radiation (XRT) with or without surgery.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 107-107
Author(s):  
Devin Schellenberg ◽  
Renata Peixoto ◽  
Andrea Lee ◽  
Howard John Lim
Keyword(s):  
Radiation Dose ◽  
Locally Advanced ◽  
Progression Free Survival ◽  
Pathologic Response ◽  
Rank Test ◽  
Tumor Characteristics ◽  
Free Survival ◽  
Chi Squared ◽  
Pre Treatment

107 Background: The 2012 CROSS trial demonstrated an overall survival (OS) benefit for neoadjuvant, concurrent Carboplatin-Paclitaxel (CP) and radiation versus surgery alone. Based on this trial, the standard chemotherapy treatment for locally advanced esophageal (LAE) cancer in British Columbia (BC) became CP instead of Cisplatin-5FU (CF). This study evaluates the pCR rates and progression free survival (PFS) of those patients treated immediately prior and immediately after the change in provincial standard. Methods: All BC patients with LAE cancer diagnosed between February 2010 and February 2013 who completed at least 40 Gy of neoadjuvant radiation were analyzed. Standard demographics, chemotherapy delivered, radiation dose, surgical pathology and follow-up data were collected. Pathologic response was compared by chi-squared analysis. Patients were followed until death or last follow-up. Survival was compared by log-rank test. Results: Seventy-three patients received CF and 39 received CP. The tumor characteristics of the subgroups were similar: squamous histology was 57% (CF) vs. 49% (CP), node positivity rate on pre-treatment PET scan was 66 vs. 67%, and median tumor length was 5.7 vs. 5.8 cm. Median radiation dose was 50 Gy in both arms. The CP arm was slightly older (Median 66 vs. 61 yo) and had a greater percentage of males (80% vs. 57%). Forty eight and 49% percent of patients were able to undergo resection. The pCR rates were 49% (CF) vs. 16% (CP) (p<0.01) in the surgical subgroups. Median FU was 14.5 (CF) vs. 9.3 (CP) months. Median PFS for all patients was 16.5 (CF) and 14.6 (CP) (p=0.44). Median PFS in surgical patients was 23.4 months (CF) and 14.6 months (CP) (p=0.16. Conclusions: In patients with similar tumor characteristics, XRT with CF resulted in greater pCR rates than with CP. The pCR rate in the CP subgroup is lower than the 29% seen in the trial. With relatively short follow-up, no difference in PFS has yet been identified. [Table: see text]

Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice

2007 ◽  
Vol 83 (3) ◽  
pp. 311-315 ◽  
Author(s):  
Christina Schütze ◽  
Ralf Bergmann ◽  
Ala Yaromina ◽  
Franziska Hessel ◽  
Jörg Kotzerke ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Local Control ◽  
Nude Mice ◽  
Fdg Uptake ◽  
Pre Treatment

EELS characterization of “Smut” layer films on steel surface prepared for chrome plating by anodic etching

1995 ◽  
Vol 53 ◽  
pp. 538-539
Author(s):  
E Y. Wang ◽  
J. T. Cherian ◽  
A. Madsen ◽  
R. M. Fisher
Keyword(s):  
Steel Surface ◽  
Surface Preparation ◽  
Treatment Method ◽  
Chrome Plating ◽  
Transmission Electron ◽  
Alloy Steels ◽  
Pre Treatment ◽  
Hard Chrome ◽  
Electron Energy Loss

Many steel parts are electro-plated with chromium to protect them against corrosion and to improve their wear-resistance. Good adhesion of the chrome plate to the steel surface, which is essential for long term durability of the part, is extremely dependent on surface preparation prior to plating. Recently, McDonnell Douglas developed a new pre-treatment method for chrome plating in which the steel is anodically etched in a sulfuric acid and hydrofluoric acid solution. On carbon steel surfaces, this anodic pre-treatment produces a dark, loosely adhering material that is commonly called the “smut” layer. On stainless steels and nickel alloys, the surface is only darkened by the anodic pre-treatment and little residue is produced. Anodic pre-treatment prior to hard chrome plating results in much better adherence to both carbon and alloy steels.We have characterized the anodic pre-treated steel surface and the resulting “smut” layer using various techniques including electron spectroscopy for chemical analysis (ESCA) on bulk samples and transmission electron microscopy (TEM) and electron energy-loss spectroscopy (EELS) on stripped films.

Evaluating the effect of a group pre-treatment chemotherapy psycho-education session for chemotherapy-naive gynecologic cancer patients and their caregivers

2021 ◽  
Vol 160 (1) ◽  
pp. 234-243
Author(s):  
Diana Samoil ◽  
Nazek Abdelmutti ◽  
Lisa Ould Gallagher ◽  
Nazlin Jivraj ◽  
Naa Kwarley Quartey ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Gynecologic Cancer ◽  
Education Session ◽  
Pre Treatment
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