A single dose of intravenous combretastatin A4-phosphate is reasonably well tolerated and significantly reduces tumour vascularization in canine spontaneous cancers

2018 ◽  
Vol 16 (4) ◽  
pp. 467-477 ◽  
Author(s):  
E. Abma ◽  
W. De Spiegelaere ◽  
K. Vanderperren ◽  
E. Stock ◽  
L. Van Brantegem ◽  
...  
Keyword(s):  
Single Dose ◽  
Combretastatin A4 ◽  
Tumour Vascularization

scholarly journals Histopathological and functional changes in a single-dose model of combretastatin A4 disodium phosphate-induced myocardial damage in rats

2018 ◽  
Vol 31 (4) ◽  
pp. 307-313 ◽  
Author(s):  
Ryota Tochinai ◽  
Kayoko Komatsu ◽  
Junta Murakami ◽  
Yuriko Nagata ◽  
Minoru Ando ◽  
...  
Keyword(s):  
Single Dose ◽  
Myocardial Damage ◽  
Functional Changes ◽  
Disodium Phosphate ◽  
Combretastatin A4 ◽  
Dose Model

scholarly journals Cardiovascular Safety Profile of Combretastatin A4 Phosphate in a Single-Dose Phase I Study in Patients with Advanced Cancer

2004 ◽  
Vol 10 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Matthew M. Cooney ◽  
Tomas Radivoyevitch ◽  
Afshin Dowlati ◽  
Beth Overmoyer ◽  
Nathan Levitan ◽  
...  
Keyword(s):  
Single Dose ◽  
Phase I ◽  
Advanced Cancer ◽  
Safety Profile ◽  
Phase I Study ◽  
Cardiovascular Safety ◽  
Combretastatin A4

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

A Single Dose of Adjuvant H1N1 Vaccine May Be OK

2010 ◽  
Vol 44 (2) ◽  
pp. 16
Author(s):  
HEIDI SPLETE
Keyword(s):  
Single Dose ◽  
H1n1 Vaccine
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