Antagonism of serotonin receptor 1B decreases viability and promotes apoptosis in the COS canine osteosarcoma cell line

2014 ◽  
Vol 14 (2) ◽  
pp. e31-e44
Author(s):  
A. K. Viall ◽  
C. P. Goodall ◽  
B. Stang ◽  
K. Marley ◽  
P. E. Chappell ◽  
...  
Keyword(s):  
Cell Line ◽  
Serotonin Receptor ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Canine Osteosarcoma

The Effect of Piroxicam, Etodolac and Flunixin on the D-17 Canine Osteosarcoma Cell Line

2014 ◽  
Vol 150 (1) ◽  
pp. 105
Author(s):  
D. Poradowski ◽  
B. Obmińska-Mrukowicz ◽  
A. Pawlak ◽  
R. Ciaputa ◽  
M. Kandefer-Gola ◽  
...  
Keyword(s):  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Canine Osteosarcoma

scholarly journals The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line

2013 ◽  
Vol 9 (1) ◽  
pp. 251 ◽  
Author(s):  
Shay Bracha ◽  
Austin Viall ◽  
Cheri Goodall ◽  
Bernadette Stang ◽  
Craig Ruaux ◽  
...  
Keyword(s):  
Cell Line ◽  
Serotonin Receptor ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell

scholarly journals Cytotoxic Effects of Artemisia annua L. and Pure Artemisinin on the D-17 Canine Osteosarcoma Cell Line

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Gloria Isani ◽  
Martina Bertocchi ◽  
Giulia Andreani ◽  
Giovanna Farruggia ◽  
Concettina Cappadone ◽  
...  
Keyword(s):  
Cell Line ◽  
Artemisia Annua ◽  
Iron Concentration ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Dependent Manner ◽  
Intracellular Iron ◽  
Cytotoxic Effects ◽  
Hydroalcoholic Extract ◽  
Canine Osteosarcoma

Artemisia annua has been used for centuries in Traditional Chinese Medicine. Although used as an antimalarial drug, its active compound artemisinin and the semisynthetic derivatives have also been investigated for their anticancer properties, with interesting and promising results. The aims of this research were to evaluate (i) the cytotoxicity and the antiproliferative effect of pure artemisinin and a hydroalcoholic extract obtained from A. annua on the D-17 canine osteosarcoma cell line and (ii) the intracellular iron concentration and its correlation with the cytotoxic effects. Both artemisinin and hydroalcoholic extract induced a cytotoxic effect in a dose-dependent manner. Pure artemisinin caused an increase of cells in the S phase, whereas the hydroalcoholic extract induced an evident increase in the G2/M phase. A significant decrease of iron concentration was measured in D-17 cells treated with pure artemisinin and hydroalcoholic extract compared to untreated cells. In conclusion, although preliminary, the data obtained in this study are indicative of a more potent cytotoxic activity of the hydroalcoholic extract than pure artemisinin, indicating a possible synergistic effect of the phytocomplex and a mechanism of action involving iron and possibly ferroptosis. Considering the similarities between human and canine osteosarcomas, progress in deepening knowledge and improving therapeutic protocols will probably be relevant for both species, in a model of reciprocal translational medicine.

Development of a new canine osteosarcoma cell line

2006 ◽  
Vol 4 (4) ◽  
pp. 232-240 ◽  
Author(s):  
B. Séguin ◽  
T. Zwerdling ◽  
J. L. McCallan ◽  
H. E. V. DeCock ◽  
L. L. Dewe ◽  
...  
Keyword(s):  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Canine Osteosarcoma

Doxorubicin induced expression of P-glycoprotein in a canine osteosarcoma cell line

1998 ◽  
Vol 126 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Katrina L Mealey ◽  
Rola Barhoumi ◽  
Kenita Rogers ◽  
Deborah T Kochevar
Keyword(s):  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Induced Expression ◽  
Canine Osteosarcoma ◽  
P Glycoprotein
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