scholarly journals Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma

2013 ◽  
Vol 13 (3) ◽  
pp. 203-217 ◽  
Author(s):  
C. K. Martin ◽  
W. P. Dirksen ◽  
M. M. Carlton ◽  
L. G. Lanigan ◽  
S. P. Pillai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Zoledronic Acid ◽  
Bone Loss ◽  
Oral Squamous Cell Carcinoma ◽  
Mouse Model ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumour Growth ◽  
Orthotopic Mouse Model

scholarly journals Zoledronic Acid Reduces Bone Loss and Tumor Growth in an Orthotopic Xenograft Model of Osteolytic Oral Squamous Cell Carcinoma

2010 ◽  
Vol 70 (21) ◽  
pp. 8607-8616 ◽  
Author(s):  
Chelsea K. Martin ◽  
Jillian L. Werbeck ◽  
Nanda K. Thudi ◽  
Lisa G. Lanigan ◽  
Tobie D. Wolfe ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Zoledronic Acid ◽  
Bone Loss ◽  
Oral Squamous Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Xenograft Model ◽  
Orthotopic Xenograft ◽  
Orthotopic Xenograft Model

Inhibitory effect of neoadjuvant chemotherapy on metastasis of oral squamous cell carcinoma in a mouse model

Oral Oncology ◽  
2009 ◽  
Vol 45 (9) ◽  
pp. 794-797 ◽  
Author(s):  
Shuichi Kawashiri ◽  
Natsuyo Noguchi ◽  
Akira Tanaka ◽  
Hiromitsu Nakaya ◽  
Koroku Kato ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Oral Squamous Cell Carcinoma ◽  
Mouse Model ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inhibitory Effect

scholarly journals A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma

2019 ◽  
Vol 18 (3) ◽  
pp. 324-341 ◽  
Author(s):  
Ali Khammanivong ◽  
Jhuma Saha ◽  
Angela K. Spartz ◽  
Brent S. Sorenson ◽  
Alexander G. Bush ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumour Growth ◽  
Mitochondrial Metabolism ◽  
Dual Inhibitor

Zoledronic acid and irradiation in oral squamous cell carcinoma

2014 ◽  
Vol 44 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Pia Lopez Jornet ◽  
Sanchez Carrillo Susana ◽  
Tudela Mulero Rosario ◽  
Pons-Fuster Alvaro
Keyword(s):  
Squamous Cell Carcinoma ◽  
Zoledronic Acid ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals A Versatile Orthotopic Nude Mouse Model for Study of Esophageal Squamous Cell Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Joseph Chok Yan Ip ◽  
Josephine Mun Yee Ko ◽  
Valen Zhuoyou Yu ◽  
Kwok Wah Chan ◽  
Alfred K. Lam ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Mouse Model ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Orthotopic Model ◽  
Nude Mouse Model ◽  
Orthotopic Mouse Model

Increasing evidence indicates tumor-stromal interactions play a crucial role in cancer. Anin vivoesophageal squamous cell carcinoma (ESCC) orthotopic animal model was developed with bioluminescence imaging established with a real-time monitoring platform for functional and signaling investigation of tumor-stromal interactions. The model was produced by injection of luciferase-labelled ESCC cells into the intraesophageal wall of nude mice. Histological examination indicates this orthotopic model is highly reproducible with 100% tumorigenesis among the four ESCC cell lines tested. This new model recapitulates many clinical and pathological properties of human ESCC, including esophageal luminal stricture by squamous cell carcinoma with nodular tumor growth, adventitia invasion, lymphovascular invasion, and perineural infiltration. It was tested using an AKT shRNA knockdown of ESCC cell lines and thein vivotumor suppressive effects of AKT knockdown were observed. In conclusion, this ESCC orthotopic mouse model allows investigation of gene functions of cancer cells in a more natural tumor microenvironment and has advantages over previous established models. It provides a versatile platform with potential application for metastasis and therapeutic regimen testing.

scholarly journals IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma

2009 ◽  
Vol 124 (6) ◽  
pp. 1440-1448 ◽  
Author(s):  
Mitomu Kioi ◽  
Takeshi Shimamura ◽  
Hideyuki Nakashima ◽  
Makoto Hirota ◽  
Iwai Tohnai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Antitumor Activity ◽  
Oral Squamous Cell Carcinoma ◽  
Mouse Model ◽  
Cell Carcinoma ◽  
Squamous Cell
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