scholarly journals Long‐term Kidney Function and Survival in Recipients of Allografts from Living Kidney Donors with Hypertension: A National Cohort Study

2021 ◽  
Author(s):  
Fawaz Al Ammary ◽  
Sile Yu ◽  
Abimereki D. Muzaale ◽  
Dorry L. Segev ◽  
Luckmini Liyanage ◽  
...  
2019 ◽  
Vol 51 (5) ◽  
pp. 1563-1567
Author(s):  
P.R. Bicalho ◽  
L.R. Requião-Moura ◽  
M. Borrelli Júnior ◽  
M.F. Rodrigues da Silva ◽  
A. Pacheco-Silva

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Nidhi Aggarwal ◽  
Anna C. Porter ◽  
Ignatius Y. S. Tang ◽  
Bryan N. Becker ◽  
Sanjeev K. Akkina

Accurate assessment of kidney function by measurement of glomerular filtration rate (GFR) is essential to the risk assessment of prospective living kidney donors. We evaluated the performance of various estimating equations for creatinine clearance (Cockcroft-Gault), GFR (Modification of Diet in Renal Disease, Chronic Kidney Disease Epidemiology Collaboration), and 24-hour urine collections for creatinine clearance in obese potential kidney donors. We evaluated 164 potential kidney donors including 49 with a BMI of 30–35 and 32 with a BMI >35 that have completed a routine living donor evaluation with a measured GFR. All the estimating equations performed poorly in obese donors. While 24-hour urine collections performed better, only 15% had an adequate 24-hour urine collection. Since obese kidney donors may be at higher than average risk for kidney failure, accurate assessment of kidney function in these donors is crucial to ensure their long-term health postdonation.


2011 ◽  
Vol 11 (3) ◽  
pp. 463-469 ◽  
Author(s):  
K. Clemens ◽  
N. Boudville ◽  
M. A. Dew ◽  
C. Geddes ◽  
J. S. Gill ◽  
...  

2014 ◽  
Vol 98 ◽  
pp. 483-484
Author(s):  
K. Keung ◽  
G. Wong ◽  
F. Yuan ◽  
P. OʼConnell ◽  
J. Chapman ◽  
...  

2020 ◽  
Vol 34 (9) ◽  
Author(s):  
Madeleine M. Waldram ◽  
Alvin G. Thomas ◽  
Yifan Yu ◽  
Courtenay M. Holscher ◽  
Anh Q. Nguyen ◽  
...  

2005 ◽  
Vol 37 (8) ◽  
pp. 3351-3353 ◽  
Author(s):  
H. Goecke ◽  
A.M. Ortiz ◽  
P. Troncoso ◽  
L. Martinez ◽  
A. Jara ◽  
...  

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0000832021
Author(s):  
Atsushi Hesaka ◽  
Yusuke Tsukamoto ◽  
Shigeyuki Nada ◽  
Masataka Kawamura ◽  
Naotsugu Ichimaru ◽  
...  

Background: D-Serine, a long-term undetected enantiomer of serine, is a biomarker that reflects kidney function and disease activity. The physiological functions of D-serine have been unclear. Methods: Dynamics of D-serine was assessed by measuring D-serine in human samples of living kidney donors using two-dimensional high-performance liquid chromatography, and by auto-radiographic studies in mice. Effects of D-serine on kidney were examined by gene expression profiling and metabolic studies using unilateral nephrectomy mice, and genetically modified cells. Results: Unilateral nephrectomy in human living kidney donors decreases urinary excretion and thus increases the blood level of D-serine. D-Serine is quickly and dominantly distributed to the kidney upon injection in mice, suggesting that the kidney is a main target organ. Treatment of D-serine at low dose promotes the enlargement of remnant kidney in mouse model. Mechanistically, D-serine activates the cell cycle for tissue remodeling through an mTOR-related pathway. Conclusions: D-Serine is a physiological molecule that promotes kidney remodeling. Besides its function as a biomarker, D-serine has a physiological activity that influences kidney function.


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