scholarly journals Donor-specific antibodies after pediatric liver transplantation: a cross-sectional study of 50 patients

2016 ◽  
Vol 29 (4) ◽  
pp. 494-505 ◽  
Author(s):  
Jesper M. Kivelä ◽  
Silja Kosola ◽  
Juha Peräsaari ◽  
Heikki Mäkisalo ◽  
Hannu Jalanko ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Cross Sectional Study ◽  
Pediatric Liver Transplantation ◽  
Sectional Study ◽  
Cross Sectional ◽  
Specific Antibodies ◽  
Pediatric Liver ◽  
Donor Specific Antibodies

scholarly journals Late hepatic artery thrombosis after pediatric liver transplantation: A cross-sectional study of 34 patients

2014 ◽  
Vol 20 (5) ◽  
pp. 591-600 ◽  
Author(s):  
Jesper M. Kivelä ◽  
Silja Kosola ◽  
Teija Kalajoki-Helmiö ◽  
Heikki Mäkisalo ◽  
Hannu Jalanko ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatic Artery ◽  
Cross Sectional Study ◽  
Hepatic Artery Thrombosis ◽  
Pediatric Liver Transplantation ◽  
Sectional Study ◽  
Cross Sectional ◽  
Artery Thrombosis ◽  
Pediatric Liver

scholarly journals Impact of donor-specific antibodies on long-term graft survival with pediatric liver transplantation

2021 ◽  
Vol 13 (6) ◽  
pp. 673-685
Author(s):  
Felicitas Leonie Schotters ◽  
Jan Beime ◽  
Andrea Briem-Richter ◽  
Thomas Binder ◽  
Uta Herden ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Pediatric Liver Transplantation ◽  
Specific Antibodies ◽  
Pediatric Liver ◽  
Donor Specific Antibodies

Long-term Clinical Relevance of De Novo Donor-Specific Antibodies After Pediatric Liver Transplantation

2015 ◽  
Vol 99 (9) ◽  
pp. 1876-1881 ◽  
Author(s):  
Enke Grabhorn ◽  
Thomas M. C. Binder ◽  
Denise Obrecht ◽  
Florian Brinkert ◽  
Anja Lehnhardt ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Clinical Relevance ◽  
De Novo ◽  
Pediatric Liver Transplantation ◽  
Specific Antibodies ◽  
Pediatric Liver ◽  
Donor Specific Antibodies

scholarly journals Autoantibodies and Donor-specific Antibodies are Associated With Graft Dysfunction in Pediatric Liver Transplantation

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Emma Monique Saelens ◽  
Stephanie Van Biervliet ◽  
Saskia Vande Velde ◽  
Myriam Van Winckel ◽  
Xavier Rogiers ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Pediatric Liver Transplantation ◽  
Graft Dysfunction ◽  
Specific Antibodies ◽  
Pediatric Liver ◽  
Donor Specific Antibodies

scholarly journals GROWTH OF CHILDREN AFTER LIVER TRANSPLANTATION (LT): LONGITUDINAL AND CROSS-SECTIONAL STUDY

1993 ◽  
Vol 33 ◽  
pp. S47-S47
Author(s):  
F Buzi ◽  
A M Bontempelli ◽  
D Alberti ◽  
A Pilotta ◽  
A Lombardi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals PREOPERATIVE RISK FACTORS FOR ACUTE KIDNEY INJURY AFTER LIVER TRANSPLANTATION: RESULTS FROM A CROSS-SECTIONAL STUDY IN NORTHEAST OF BRAZIL

2018 ◽  
Vol 55 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Raimundo Martins GOMES JUNIOR ◽  
Lia Cavalcante CEZAR ◽  
Gdayllon Cavalcante MENESES ◽  
Geraldo Bezerra da SILVA JUNIOR ◽  
José Huygenes Parente GARCIA ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Serum Albumin ◽  
Kidney Injury ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Preoperative Risk ◽  
Cross Sectional ◽  
Preoperative Risk Factors

ABSTRACT BACKGROUND: Acute kidney injury (AKI) is a common complication in the immediate postoperative period of patients undergoing liver transplantation. OBJECTIVE: The aim of this study was to evaluate preoperative risk factors for AKI after liver transplantation. METHODS: A cross-sectional study was conducted with adults submitted to orthotopic liver transplantation at a reference hospital in Fortaleza, Northeast of Brazil, from January to December 2016. Preoperative risk factors were evaluated for AKI development in the immediate postoperative period. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. RESULTS: A total of 40 patients were included in the study. AKI was found in 85% of patients in the first 24 hours after transplantation, most of them (40%) classified in KDIGO stage 1. Preoperative data indicate that serum albumin levels were lower in the KDIGO stage 3 group compared to the non-AKI group, as well as the hematocrit levels. Direct bilirubin (DB) was higher in the KDIGO stage 3 group compared to the group without AKI, as well as alkaline phosphatase (AP) and gamma-glutamiltransferase (GGT). In a logistic regression analysis independent risk factors for AKI were increase levels of AP, GGT and DB and decrease level of serum albumin. CONCLUSION: Low levels of serum albumin, and elevated levels of DB, AP and GGT in the preoperative period are risk factors for AKI development after liver transplantation.

scholarly journals Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ahad Eshraghian ◽  
Elham Moasser ◽  
Negar Azarpira ◽  
Mohammad Reza Fattahi ◽  
Saman Nikeghbalian ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Hepatic Steatosis ◽  
Cross Sectional Study ◽  
Genetic Variations ◽  
Transplant Recipients ◽  
Sectional Study ◽  
Proprotein Convertase ◽  
Cross Sectional ◽  
Liver Transplant Recipients

Abstract Background Genetic abnormalities might have important role in pathogenesis of hepatic steatosis after liver transplantation. We aimed to investigate association between genetic variations in transmembrane 6 superfamily member 2 (TM6SF2) rs58542926, proprotein convertase subtilisin/kexin type 9 (PCSK9) rs505151 and proprotein convertase subtilisin/kexin type 7 (PCSK7) rs2277287 with hepatic steatosis in liver transplant recipients. Methods In a cross-sectional study, adult (> 18 years) liver transplant recipients who were referred for their routine post-transplant follow-up between June 2018 and September 2018 were included in the study. Hepatic steatosis in transplant recipients was assessed by controlled attenuation parameter (CAP). Polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) was used to study TM6SF2 rs58542926, PCSK7 rs2277287 and PCSK9 rs505151 genotypes. Results 107 liver transplant recipients were included. There was no association between different genotypes of PCSK9 rs505151 and PCSK7 rs2277287 with hepatic steatosis in liver transplant recipients (P value > 0.05). The presence of TT genotype of TM6SF2 rs58542926 was higher in patients with hepatic steatosis measured by CAP after liver transplantation. In patients with moderate and severe hepatic steatosis (grade 2 and 3 steatosis), AG + GG genotypes of PCSK9 rs505151 were more prevalent than AA genotype (OR 8.667; 95% CI 1.841–40.879; P value = 0.004) compared to patients with mild steatosis (grade 1). In multivariate regression model, AG + GG genotypes of PCSK9 rs505151 were associated with moderate and severe steatosis in liver transplant recipients (OR 5.747; 95% CI 1.086–30.303; P value = 0.040). Conclusions Genetic variations in TM6SF2 rs58542926 and PCSK9 rs505151 might be associated with hepatic steatosis in liver transplant recipients.

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