scholarly journals Safety profile of low‐titer group O whole blood in pediatric patients with massive hemorrhage

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Katrina M. Morgan ◽  
Mark H. Yazer ◽  
Darrell J. Triulzi ◽  
Stephen Strotmeyer ◽  
Barbara A. Gaines ◽  
...  
Keyword(s):  
Safety Profile ◽  
Whole Blood ◽  
Pediatric Patients ◽  
Massive Hemorrhage ◽  
Titer Group

Safety profile and impact of low-titer group O whole blood for emergency use in trauma

2020 ◽  
Vol 88 (1) ◽  
pp. 87-93 ◽  
Author(s):  
James Williams ◽  
Nicholas Merutka ◽  
David Meyer ◽  
Yu Bai ◽  
Samuel Prater ◽  
...  
Keyword(s):  
Safety Profile ◽  
Whole Blood ◽  
Titer Group

Safety profile of uncrossmatched, cold-stored, low-titer, group O+ whole blood in civilian trauma patients

Transfusion ◽  
2018 ◽  
Vol 58 (10) ◽  
pp. 2280-2288 ◽  
Author(s):  
Jansen N. Seheult ◽  
Marshall Bahr ◽  
Vincent Anto ◽  
Louis H. Alarcon ◽  
Alain Corcos ◽  
...  
Keyword(s):  
Safety Profile ◽  
Whole Blood ◽  
Trauma Patients ◽  
Civilian Trauma ◽  
Titer Group

scholarly journals Survey to inform trial of low‐titer group O whole‐blood compared to conventional blood components for children with severe traumatic bleeding

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Julia H. Kolodziej ◽  
Julie C. Leonard ◽  
Cassandra D. Josephson ◽  
Barbara A. Gaines ◽  
Stephen R. Wisniewski ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Components ◽  
Titer Group ◽  
Traumatic Bleeding

Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients

2001 ◽  
Vol 29 (4) ◽  
pp. 870-877 ◽  
Author(s):  
Jeremy Lyons ◽  
Astrid Rauh-Pfeiffer ◽  
Yong Ming-Yu ◽  
Xiao-Ming Lu ◽  
David Zurakowski ◽  
...  
Keyword(s):  
Whole Blood ◽  
Pediatric Patients ◽  
Glutathione Synthesis ◽  
Cysteine Metabolism

scholarly journals Monitoring Tacrolimus Concentrations in Whole Blood and Peripheral Blood Mononuclear Cells: Inter- and Intra-Patient Variability in a Cohort of Pediatric Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Amedeo De Nicolò ◽  
Michele Pinon ◽  
Alice Palermiti ◽  
Antonello Nonnato ◽  
Alessandra Manca ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Whole Blood ◽  
Peripheral Blood ◽  
Pediatric Patients ◽  
Mononuclear Cells ◽  
Individual Variability ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Intracellular Concentrations ◽  
The One

Tacrolimus (TAC) is a first-choice immunosuppressant for solid organ transplantation, characterized by high potential for drug-drug interactions, significant inter- and intra-patient variability, and narrow therapeutic index. Therapeutic drug monitoring (TDM) of TAC concentrations in whole blood (WB) is capable of reducing the incidence of adverse events. Since TAC acts within lymphocytes, its monitoring in peripheral blood mononuclear cells (PBMC) may represent a valid future alternative for TDM. Nevertheless, TAC intracellular concentrations and their variability are poorly described, particularly in the pediatric context. Therefore, our aim was describing TAC concentrations in WB and PBMC and their variability in a cohort of pediatric patients undergoing constant immunosuppressive maintenance therapy, after liver transplantation. TAC intra-PBMCs quantification was performed through a validated UHPLC–MS/MS assay over a period of 2–3 months. There were 27 patients included in this study. No significant TAC changes in intracellular concentrations were observed (p = 0.710), with a median percent change of −0.1% (IQR −22.4%–+46.9%) between timings: this intra-individual variability was similar to the one in WB, −2.9% (IQR −29.4–+42.1; p = 0.902). Among different patients, TAC weight-adjusted dose and age appeared to be significant predictors of TAC concentrations in WB and PBMC. Intra-individual seasonal variation of TAC concentrations in WB, but not in PBMC, have been observed. These data show that the intra-individual variability in TAC intracellular exposure is comparable to the one observed in WB. This opens the way for further studies aiming at the identification of therapeutic ranges for TAC intra-PBMC concentrations.

Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Barbara A. Gaines ◽  
Mark H. Yazer ◽  
Darrell J. Triulzi ◽  
Jason L. Sperry ◽  
Matthew D. Neal ◽  
...  
Keyword(s):  
Whole Blood ◽  
Massive Transfusion ◽  
Titer Group

25482 Secukinumab efficacy and safety profile in pediatric patients with severe chronic plaque psoriasis up to 1 year

2021 ◽  
Vol 85 (3) ◽  
pp. AB59
Author(s):  
Christine Bodemer ◽  
Andrzej Kaszuba ◽  
Külli Kingo ◽  
Athanasios Tsianakas ◽  
Akimichi Morita ◽  
...  
Keyword(s):  
Plaque Psoriasis ◽  
Safety Profile ◽  
Pediatric Patients ◽  
Efficacy And Safety ◽  
Chronic Plaque Psoriasis
Sign in / Sign up

Export Citation Format

Share Document