scholarly journals Brief report: Production of anti‐SARS‐CoV ‐2 hyperimmune globulin from convalescent plasma

Transfusion ◽  
2021 ◽  
Author(s):  
Peter Vandeberg ◽  
Maria Cruz ◽  
Jose Maria Diez ◽  
W. Keither Merritt ◽  
Benjamin Santos ◽  
...  
Keyword(s):  
Hyperimmune Globulin

scholarly journals Preparation and development of equine hyperimmune globulin F(ab')2 against severe acute respiratory syndrome coronavirus1

2005 ◽  
Vol 26 (12) ◽  
pp. 1479-1484 ◽  
Author(s):  
Jai-hai LU ◽  
Zhong-min GUO ◽  
Wen-yu HAN ◽  
Guo-ling WANG ◽  
Ding-mei ZHANG ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Hyperimmune Globulin

scholarly journals A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus

2014 ◽  
Vol 370 (14) ◽  
pp. 1316-1326 ◽  
Author(s):  
Maria Grazia Revello ◽  
Tiziana Lazzarotto ◽  
Brunella Guerra ◽  
Arsenio Spinillo ◽  
Enrico Ferrazzi ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Congenital Cytomegalovirus ◽  
Hyperimmune Globulin

Comparison of combined prophylaxis of cytomegalovirus hyperimmune globulin plus ganciclovir versus cytomegalovirus hyperimmune globulin alone in high-risk heart transplant recipients1

2004 ◽  
Vol 77 (6) ◽  
pp. 890-897 ◽  
Author(s):  
Nikolaos E. Bonaros ◽  
Alfred Kocher ◽  
Daniela Dunkler ◽  
Michael Grimm ◽  
Andreas Zuckermann ◽  
...  
Keyword(s):  
High Risk ◽  
Heart Transplant ◽  
Hyperimmune Globulin

A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection

2022 ◽  
Vol 77 (1) ◽  
pp. 16-18
Author(s):  
Brenna L. Hughes ◽  
Rebecca G. Clifton ◽  
Dwight J. Rouse ◽  
George R. Saade ◽  
Mara J. Dinsmoor ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Hyperimmune Globulin

scholarly journals Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas

Vaccines ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 135 ◽  
Author(s):  
Takako Tabata ◽  
Matthew Petitt ◽  
June Fang-Hoover ◽  
Daniel C. Freed ◽  
Fengsheng Li ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Human Cytomegalovirus ◽  
Virus Transmission ◽  
Passive Immunization ◽  
First Trimester ◽  
Clinical Strain ◽  
Stromal Fibroblasts ◽  
Virion Assembly ◽  
Effective Strategies ◽  
Hyperimmune Globulin

Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown. We measured the efficacy of human monoclonal antibodies (mAbs) to HCMV attachment/entry factors glycoprotein B (gB) and the pentameric complex, gH/gL-pUL128–131, in preventing infection and spread of a clinical strain in primary placental cells and explants of developing anchoring villi. A total of 109 explants from five first-trimester placentas were cultured, and infection was analyzed in over 400 cell columns containing ~120,000 cytotrophoblasts (CTBs). mAbs to gB and gH/gL, 3-25 and 3-16, respectively, neutralized infection in stromal fibroblasts and trophoblast progenitor cells. mAbs to pUL128-131 of the pentameric complex, 1-103 and 2-18, neutralized infection of amniotic epithelial cells better than mAbs 3-25 and 3-16 and hyperimmune globulin. Select mAbs neutralized infection of cell column CTBs, with mAb 2-18 most effective, followed by mAb 3-25. Treatment of anchoring villi with mAbs postinfection reduced spread in CTBs and impaired formation of virion assembly compartments, with mAb 2-18 achieving better suppression at lower concentrations. These results predict that antibodies generated by HCMV vaccines or used for passive immunization have the potential to reduce transplacental transmission and congenital disease.

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