scholarly journals Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress

Transfusion ◽  
2020 ◽  
Author(s):  
Kelsey Hazegh ◽  
Fang Fang ◽  
Marjorie D. Bravo ◽  
Johnson Q. Tran ◽  
Marcus O. Muench ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Cold Storage ◽  
Blood Donor ◽  
Red Blood Cell ◽  
Cell Metabolism ◽  
And Oxidative Stress

scholarly journals Blood Donor Exposome and Impact of Common Drugs on Red Blood Cell Metabolism

2020 ◽  
Author(s):  
Travis Nemkov ◽  
Davide Stefanoni ◽  
Aarash Bordbar ◽  
Aaron Issaian ◽  
Bernhard Palsson ◽  
...  
Keyword(s):  
Blood Cell ◽  
Blood Donor ◽  
Red Blood Cell ◽  
Cell Metabolism

scholarly journals Blood donor exposome and impact of common drugs on red blood cell metabolism

JCI Insight ◽  
2020 ◽  
Author(s):  
Travis Nemkov ◽  
Davide Stefanoni ◽  
Aarash Bordbar ◽  
Aaron Issaian ◽  
Bernhard O. Palsson ◽  
...  
Keyword(s):  
Blood Cell ◽  
Blood Donor ◽  
Red Blood Cell ◽  
Cell Metabolism

Abnormal red blood cell morphological changes in thalassaemia associated with iron overload and oxidative stress

2019 ◽  
Vol 72 (8) ◽  
pp. 520-524 ◽  
Author(s):  
Pornthip Chaichompoo ◽  
Ariz Qillah ◽  
Pornpan Sirankapracha ◽  
Jirada Kaewchuchuen ◽  
Poramate Rimthong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Red Blood Cell ◽  
Morphological Changes ◽  
Normal Subjects ◽  
Target Cells ◽  
Red Cell ◽  
And Oxidative Stress

AimsIron overload is a major factor contributing to the overall pathology of thalassaemia, which is primarily mediated by ineffective erythropoiesis and shorter mature red blood cell (RBC) survival. Iron accumulation in RBCs generates reactive oxygen species (ROS) that cause cellular damage such as lipid peroxidation and RBC membrane deformation. Abnormal RBCs in patients with thalassaemia are commonly known as microcytic hypochromic anaemia with poikilocytosis. However, iron and ROS accumulation in RBCs as related to RBC morphological changes in patients with thalassaemia has not been reported.MethodsTwenty-one patients with thalassaemia, including HbH, HbH with Hb Constant Spring and β-thalassaemia/HbE (splenectomy and non-splenectomy) genotypes, and five normal subjects were recruited. RBC morphology was analysed by light and scanning electron microscopy. Systemic and RBC iron status and oxidative stress were examined.ResultsDecreased normocytes were observed in the samples of patients with thalassaemia, with RBC morphological abnormality being related to the type of disease (α-thalassaemia or β-thalassaemia) and splenic status. Target cells and crenated cells were mainly found in splenectomised patients with β-thalassaemia/HbE, while target cells and teardrop cells were found in non-splenectomised patients. Patients with thalassaemia had high levels of serum ferritin, red cell ferritin and ROS in RBCs compared with normal subjects (p<0.05). Negative correlations between the amount of normocytes and serum ferritin (rs=−0.518, p=0.011), red cell ferritin (rs=−0.467, p=0.025) or ROS in RBCs (rs=−0.672, p<0.001) were observed.ConclusionsIron overload and its consequent intracellular oxidative stress in RBCs were associated with reduce normocytes in patients with thalassaemia.

Effects of oxidative stress on red blood cell rheology in sickle cell patients

2014 ◽  
Vol 166 (4) ◽  
pp. 601-606 ◽  
Author(s):  
Régine Hierso ◽  
Xavier Waltz ◽  
Pierre Mora ◽  
Marc Romana ◽  
Nathalie Lemonne ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Cell Rheology

scholarly journals The Effects of Cyanate In Vitro on Red Blood Cell Metabolism and Function in Sickle Cell Anemia

1972 ◽  
Vol 51 (3) ◽  
pp. 566-574 ◽  
Author(s):  
Frank G. De Furia ◽  
Denis R. Miller ◽  
Anthony Cerami ◽  
James M. Manning
Keyword(s):  
Blood Cell ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Red Blood Cell ◽  
Cell Metabolism ◽  
And Function

scholarly journals Deformability based sorting of stored red blood cells reveals donor-dependent aging curves

Lab on a Chip ◽  
2020 ◽  
Vol 20 (2) ◽  
pp. 226-235 ◽  
Author(s):  
Emel Islamzada ◽  
Kerryn Matthews ◽  
Quan Guo ◽  
Aline T. Santoso ◽  
Simon P. Duffy ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Cold Storage ◽  
Red Blood Cell ◽  
Cell Sorting ◽  
Blood Cells ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Cell sorting using microfluidic ratchets enables sensitive and consistent characterization of donor red blood cell deformability. Using this capability, we show the degradation of red blood cell deformability during cold storage is donor-dependent.

scholarly journals Impact of taurine on red blood cell metabolism and implications for blood storage

Transfusion ◽  
2020 ◽  
Vol 60 (6) ◽  
pp. 1212-1226 ◽  
Author(s):  
Lorenzo Bertolone ◽  
Micaela Kalani Roy ◽  
Ariel M. Hay ◽  
Evan J. Morrison ◽  
Davide Stefanoni ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Metabolism ◽  
Blood Storage
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