Prehospital transfusion of low titer cold‐stored whole blood through the intraosseous route in a trauma patient with hemorrhagic shock

Transfusion ◽  
2020 ◽  
Vol 60 (4) ◽  
pp. 875-878
Author(s):  
Raviv Allon ◽  
Danny Epstein ◽  
Itai Shavit
Keyword(s):  
Hemorrhagic Shock ◽  
Trauma Patient ◽  
Whole Blood

Use of levarterenol in treatment of irreversible hemorrhagic shock

1959 ◽  
Vol 196 (5) ◽  
pp. 1029-1032 ◽  
Author(s):  
H. A. Fozzard ◽  
J. P. Gilmore
Keyword(s):  
Hemorrhagic Shock ◽  
Survival Time ◽  
Whole Blood ◽  
Hemorrhagic Hypotension ◽  
Effective Adjunct

The effectiveness of levarterenol in the treatment of shock resulting from prolonged oligemia was studied in the dog. The survival time of animals receiving levarterenol and whole blood therapy was significantly greater than that of animals receiving a placebo and whole blood. The results of the experiments indicate that levarterenol is an effective adjunct to whole blood therapy in the treatment of shock resulting from prolonged hemorrhagic hypotension.

Systemic and microcirculatory effects of autologous whole blood resuscitation in severe hemorrhagic shock

1999 ◽  
Vol 276 (6) ◽  
pp. H2035-H2043 ◽  
Author(s):  
Heinz Kerger ◽  
Klaus F. Waschke ◽  
Klaus V. Ackern ◽  
Amy G. Tsai ◽  
Marcos Intaglietta
Keyword(s):  
Metabolic Acidosis ◽  
Hemorrhagic Shock ◽  
Whole Blood ◽  
Tissue Perfusion ◽  
Capillary Density ◽  
Shed Blood ◽  
Syrian Golden Hamsters ◽  
Autologous Whole Blood ◽  
Significant Impairment ◽  
Main Determinants

Systemic and microcirculatory effects of autologous whole blood resuscitation after 4-h hemorrhagic shock with a mean arterial pressure (MAP) level of 40 mmHg were investigated in 63 conscious Syrian golden hamsters. Microcirculation of skeletal skin muscle and subcutaneous connective tissue was visualized in a dorsal skinfold. Shed blood was retransfused within 30 min after 4 h. Animals were grouped into survivors in good (SG) and poor condition (SP) and nonsurvivors (NS) according to 24-h outcome after resuscitation and studied before shock, during shock (60, 120, and 240 min), and 30 min and 24 h after resuscitation. Microvascular and interstitial[Formula: see text] values were determined by phosphorescence decay. Shock caused a significant increase of arterial[Formula: see text] and decrease of[Formula: see text], pH, and base excess. In the microcirculation, there was a significant decrease in blood flow (Q˙B), functional capillary density (FCD; capillaries with red blood cell flow), and interstitial [Formula: see text][1.8 ± 0.8 mmHg (SG), 1.3 ± 1.3 mmHg (SP), and 0.9 ± 1.1 mmHg (NS) vs. 23.0 ± 6.1 mmHg at control]. Blood resuscitation caused immediate MAP recompensation in all animals, whereas metabolic acidosis, hyperventilation, and a significant interstitial [Formula: see text] decrease (40–60% of control) persisted. In NS (44.4% of the animals), systemic and microcirculatory alterations were significantly more severe both in shock and after resuscitation than in survivors. Whereas in SG (31.8% of the animals) there was only a slight (15–30%) but still significant impairment of microscopic tissue perfusion (Q˙B, FCD) and oxygenation at 24 h, SP (23.8% of the animals) showed severe metabolic acidosis and substantial decreases (≥50%) of FCD and interstitial[Formula: see text]. FCD, interstitial[Formula: see text], and metabolic state were the main determinants of shock outcome.

scholarly journals Give the trauma patient what they bleed, when and where they need it: establishing a comprehensive regional system of resuscitation based on patient need utilizing cold‐stored, low‐titer O+ whole blood

Transfusion ◽  
2019 ◽  
Vol 59 (S2) ◽  
pp. 1429-1438 ◽  
Author(s):  
Caroline S. Zhu ◽  
Douglas M. Pokorny ◽  
Brian J. Eastridge ◽  
Susannah E. Nicholson ◽  
Eric Epley ◽  
...  
Keyword(s):  
Trauma Patient ◽  
Whole Blood ◽  
Regional System

Intraosseous hydroxocobalamin versus intravenous hydroxocobalamin compared to intraosseous whole blood or no treatment for hemorrhagic shock in a swine model

2015 ◽  
Vol 10 (3) ◽  
pp. 205-215 ◽  
Author(s):  
Vikhyat S. Bebarta, MD, FACEP, FACMT ◽  
Normalynn Garrett, PhD ◽  
Susan Boudreau, RN, BSN ◽  
Maria Castaneda, MS
Keyword(s):  
Hemorrhagic Shock ◽  
Whole Blood ◽  
Swine Model

Whole blood for the acutely haemorrhaging civilian trauma patient: a novel idea or rediscovery?

2016 ◽  
Vol 26 (6) ◽  
pp. 406-414 ◽  
Author(s):  
M. P. Bahr ◽  
M. H. Yazer ◽  
D. J. Triulzi ◽  
R. A. Collins
Keyword(s):  
Trauma Patient ◽  
Whole Blood ◽  
Civilian Trauma

scholarly journals Is the Whole Greater than the Sum of Its Parts? The Implementation and Outcomes of a Whole Blood Program in Ecuador

2021 ◽  
Author(s):  
Amber Nicole Himmler ◽  
Monica Eulalia Galarza Armijos ◽  
Jeovanni Reinoso Naranjo ◽  
Sandra Gioconda Peña Patiño ◽  
Doris Sarmiento Altamirano ◽  
...  
Keyword(s):  
Latin America ◽  
Hemorrhagic Shock ◽  
Whole Blood ◽  
Vital Signs ◽  
Human Albumin ◽  
Acute Care Surgery ◽  
Trauma Patients ◽  
Transfusion Reaction ◽  
Shock Index ◽  
Care Surgery

Abstract Background: Hemorrhagic shock is a major cause of mortality in low-and-middle-income countries (LMICs). Many institutions in LMICs lack the resources to adequately prescribe balanced resuscitation. This study aims to describe the implementation of a whole blood program in Latin America and to discuss the outcomes of the patients that received whole blood (WB).Methods: We conducted a retrospective review of patients resuscitated with WB from 2013-2019. Five units of O+ WB were made available on a consistent basis for patients presenting in hemorrhagic shock. Variables collected included: gender, age, service treating the patient, units of WB administered, units of components administered, admission vital signs, admission hemoglobin, Shock Index, Revised Trauma Score (RTS) in trauma patients, intraoperative crystalloid (lactated ringers or normal saline) and colloid (5% human albumin) administration, symptoms of transfusion reaction, length-of-stay and in-hospital mortality.Results: The sample includes a total of 101 patients, 57 of whom were trauma and acute care surgery (TACS) patients and 44 of whom were obstetrics and gynecology patients. No patients developed symptoms consistent with a transfusion reaction. Average shock index was 1.16 (±0.55). On average, patients received 1.66 (±0.80) units of whole blood. Overall mortality was 14/101 (13.86%) in the first 24 hours and 6/101 (5.94%) after 24 hours.Conclusion: Implementing a WB protocol is achievable in LMICs. Whole blood allows for more efficient delivery of hemostatic resuscitation and is ideal for resource-restrained settings. To our knowledge, this is the first description of a whole blood program implemented in a civilian hospital in Latin America.

Treatment of combined traumatic brain injury and hemorrhagic shock with fractionated blood products versus fresh whole blood in a rat model

2018 ◽  
Vol 45 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Akiva Leibowitz ◽  
Evgeni Brotfain ◽  
Leonid Koyfman ◽  
Moti Klein ◽  
Shmuel Hess ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Rat Model ◽  
Whole Blood ◽  
Blood Products
Sign in / Sign up

Export Citation Format

Share Document