scholarly journals Hemolytic markers following the transfusion of uncrossmatched, cold‐stored, low‐titer, group O+ whole blood in civilian trauma patients

Transfusion ◽  
2020 ◽  
Vol 60 (S3) ◽  
Author(s):  
Ian M. Harrold ◽  
Jansen N. Seheult ◽  
Louis H. Alarcon ◽  
Alain Corcos ◽  
Jason L. Sperry ◽  
...  
Keyword(s):  
Whole Blood ◽  
Trauma Patients ◽  
Civilian Trauma ◽  
Titer Group

The use of low-titer group O whole blood for the resuscitation of civilian trauma patients in 2018

Transfusion ◽  
2018 ◽  
Vol 58 (11) ◽  
pp. 2744-2746 ◽  
Author(s):  
Mark H. Yazer ◽  
Philip C. Spinella
Keyword(s):  
Whole Blood ◽  
Trauma Patients ◽  
Civilian Trauma ◽  
Titer Group

A Pilot Study of Stored Low Titer Group O Whole Blood + Component Therapy versus Component Therapy Only for Civilian Trauma Patients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Anaar E. Siletz ◽  
Kevin J. Blair ◽  
Richelle J. Cooper ◽  
N. Charity Nguyen ◽  
Scott J. Lewis ◽  
...  
Keyword(s):  
Pilot Study ◽  
Whole Blood ◽  
Blood Component ◽  
Trauma Patients ◽  
Civilian Trauma ◽  
Blood Component Therapy ◽  
Titer Group

Safety profile of uncrossmatched, cold-stored, low-titer, group O+ whole blood in civilian trauma patients

Transfusion ◽  
2018 ◽  
Vol 58 (10) ◽  
pp. 2280-2288 ◽  
Author(s):  
Jansen N. Seheult ◽  
Marshall Bahr ◽  
Vincent Anto ◽  
Louis H. Alarcon ◽  
Alain Corcos ◽  
...  
Keyword(s):  
Safety Profile ◽  
Whole Blood ◽  
Trauma Patients ◽  
Civilian Trauma ◽  
Titer Group

Clinical outcomes among low-titer group O whole blood recipients compared to recipients of conventional components in civilian trauma resuscitation

Transfusion ◽  
2018 ◽  
Vol 58 (8) ◽  
pp. 1838-1845 ◽  
Author(s):  
Jansen N. Seheult ◽  
Vincent Anto ◽  
Louis H. Alarcon ◽  
Jason L. Sperry ◽  
Darrell J. Triulzi ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Whole Blood ◽  
Trauma Resuscitation ◽  
Civilian Trauma ◽  
Titer Group

Whole Blood Versus Conventional Blood Component Massive Transfusion Protocol Therapy in Civilian Trauma Patients

2021 ◽  
pp. 000313482110497
Author(s):  
Janet S. Lee ◽  
Abid D. Khan ◽  
Franklin L. Wright ◽  
Robert C. McIntyre ◽  
Warren C. Dorlac ◽  
...  
Keyword(s):  
Whole Blood ◽  
Injury Severity ◽  
Massive Transfusion ◽  
Blood Component ◽  
Trauma Patients ◽  
Massive Transfusion Protocol ◽  
Civilian Trauma ◽  
Transfusion Volume ◽  
Blood Component Therapy ◽  
Transfusion Protocol

Background Military data demonstrating an improved survival rate with whole blood (WB) have led to a shift toward the use of WB in civilian trauma. The purpose of this study is to compare a low-titer group O WB (LTOWB) massive transfusion protocol (MTP) to conventional blood component therapy (BCT) MTP in civilian trauma patients. Methods Trauma patients 15 years or older who had MTP activations from February 2019 to December 2020 were included. Patients with a LTOWB MTP activation were compared to BCT MTP patients from a historic cohort. Results 299 patients were identified, 169 received LTOWB and 130 received BCT. There were no differences in age, gender, or injury type. The Injury Severity Score was higher in the BCT group (27 vs 25, P = .006). The LTOWB group had a longer transport time (33 min vs 26 min, P < .001) and a lower arrival temperature (35.8 vs 36.1, P < .001). Other hemodynamic parameters were similar between the groups. The LTOWB group had a lower in-hospital mortality rate compared to the BCT group (19.5% vs 30.0%, P = .035). There were no differences in total transfusion volumes at 4 hours and 24 hours. No differences were seen in transfusion reactions or hospital complications. Multivariable logistic regression identified ISS, age, and 24-hour transfusion volume as predictors of mortality. Discussion Resuscitating severely injured trauma patient with LTOWB is safe and may be associated with an improved survival.

Whole Blood for Civilian Urban Trauma Resuscitation: Historical, Present, and Future Considerations

2020 ◽  
Vol 46 (02) ◽  
pp. 221-234
Author(s):  
Mark Walsh ◽  
Dietmar Fries ◽  
Ernest Moore ◽  
Hunter Moore ◽  
Scott Thomas ◽  
...  
Keyword(s):  
Whole Blood ◽  
Urban Population ◽  
Fixed Ratio ◽  
Trauma Patients ◽  
Trauma Population ◽  
Civilian Trauma ◽  
European Experience ◽  
Improved Outcomes ◽  
Austere Environment ◽  
Different Populations

AbstractWhole blood (WB) has been used for more than a century for far-forward combat resuscitation. Following the Iraq/Afghanistan combat, maritime, and austere environment use of WB for the resuscitation of severely hemorrhaging patients, there has been an increasing use of WB for the civilian urban resuscitation environment population. The impetus for this was not just improved outcomes in far-forward hospitals, which had different populations and different needs than the civilian urban population, but also an application of the lessons suggested by recent 1:1:1 plasma:platelets:packed red cells fixed-ratio studies for patients with massive transfusion needs. Mechanistic, logistic, and standardization concerns have been addressed and are evolving as the WB project advances. A small number of studies have been published on WB in the civilian urban trauma population. In addition, European experience with viscoelastic testing and resuscitation with fibrinogen and prothrombin complex concentrate has provided another viewpoint regarding the choice of resuscitation strategies for severely bleeding trauma patients in urban civilian environments. There are randomized controlled trials in process, which are testing the hypothesis that WB may be beneficial for the civilian urban population. Whether WB will improve mortality significantly is now a matter of intense study, and this commentary reviews the history, mechanistic foundations, and logistical aspects for the use of WB in the civilian trauma population.

Initial safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian trauma patients

2016 ◽  
Vol 81 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Mark H. Yazer ◽  
Byron Jackson ◽  
Jason L. Sperry ◽  
Louis Alarcon ◽  
Darrell J. Triulzi ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Whole Blood ◽  
Trauma Patients ◽  
Civilian Trauma
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