scholarly journals Prevalence of serologic markers of transfusion and sexually transmitted infections and their correlation with clinical features in a large cohort of Brazilian patients with sickle cell disease

Transfusion ◽  
2019 ◽  
Vol 60 (2) ◽  
pp. 343-350 ◽  
Author(s):  
Paula F. Blatyta ◽  
Shannon Kelly ◽  
Ester Sabino ◽  
Liliana Preiss ◽  
Franciane Mendes ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sexually Transmitted Infections ◽  
Clinical Features ◽  
Sickle Cell ◽  
Large Cohort ◽  
Cell Disease ◽  
Sexually Transmitted ◽  
Serologic Markers

The painful crisis of homozygous sickle cell disease: clinical features

1994 ◽  
Vol 87 (3) ◽  
pp. 586-591 ◽  
Author(s):  
Graham R. Serjeant ◽  
Charles D. E. Ceulaer ◽  
Rosemary Lethbridge ◽  
Joanne Morris ◽  
Atul Singhal and ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Clinical Features ◽  
Sickle Cell ◽  
Cell Disease ◽  
Homozygous Sickle Cell Disease ◽  
Painful Crisis

Clinical Features of Sickle Cell Disease in Eastern Saudi Arab Children

1990 ◽  
Vol 12 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Mohamed I. El Mouzan ◽  
Baker H. Al Awamy ◽  
Mohammed T. Al Torki
Keyword(s):  
Sickle Cell Disease ◽  
Clinical Features ◽  
Sickle Cell ◽  
Cell Disease ◽  
Arab Children

Pneumonia in young children with homozygous sickle cell disease: risk and clinical features

1985 ◽  
Vol 144 (3) ◽  
pp. 255-258 ◽  
Author(s):  
K. De Ceulaer ◽  
K. W. McMullen ◽  
G. H. Maude ◽  
R. Keatinge ◽  
G. R. Serjeant
Keyword(s):  
Sickle Cell Disease ◽  
Young Children ◽  
Clinical Features ◽  
Sickle Cell ◽  
Disease Risk ◽  
Cell Disease ◽  
Homozygous Sickle Cell Disease

scholarly journals Mortality of covid19 in sickle cell disease systematic review

2021 ◽  
Vol 12 (2) ◽  
pp. 151-156
Author(s):  
Waseem Bader Al Talalwah ◽  
Shorok Ali Al Dorazi
Keyword(s):  
Sickle Cell Disease ◽  
Clinical Features ◽  
Sickle Cell ◽  
Pulmonary Arteries ◽  
Beta Thalassemia ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Fourth Decade ◽  
Radiological Changes

The covid19 infection is pandemic disease are more commonly in chronic diseases. As covid19 case pulmonary infection, the current study focuses on sickle cell disease patients are suitable to acute chest syndrome. It will clarify the risk factors for covid19 infection and its clinical features in sickle cell disease. It also reviews the radiological findings to gain more data on this pandemic disease. The current study includes 44 cases of sickle cell disease having covid19 infection. The entire cases include sickle cell disease only in 89% whereas the other sickle cell disease cases are coexisted with beta- thalassemia in 9.1%. The fourth decade is the highest peak incidence. There are several complications found to be in sickle cell disease are acute chest syndrome, chronic leg ulcer, renal failure exceeding 10%. The bronchial asthma found to be in 6.9% and avascular necrosis found to be 11.4% whereas the cerebrovascular accident found to be in 13.8%. The radiological changes include lung tissues, alveoli, pleural cavities and pulmonary arteries in different rate. The incidence of recovery found to be in 93% whereas the death found to be in 7%. It found to be involving in respiratory and gastrointestinal systems result in different clinical features in different rate. This study compares the clinical features, findings investigation and complications between sex and decades. Further, this study clarifies recovery and mortality rate between sex and decades. Knowing and understanding covid19 infection in sickle cell disease, physicians will be able to provide high quality of medical services.

scholarly journals Strokes in children with sickle cell disease at the National Hospital Abuja Nigeria

2013 ◽  
Vol 40 (2) ◽  
pp. 158-164
Author(s):  
O Oniyangi ◽  
P Ahmed ◽  
OT Otuneye ◽  
J Okon ◽  
HA Aikhionbare ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Brain Imaging ◽  
Clinical Features ◽  
Sickle Cell ◽  
Stroke Recurrence ◽  
Cell Disease ◽  
Cerebral Infarcts ◽  
National Hospital ◽  
Transfusion Therapy

Background: Strokes occur in sickle cell disease (SCD), and are associated with significant morbidity and mortality.Objectives: To determine the prevalence of strokes amongst childrenwith SCD, and document the major clinical features, complications, effect of treatment with chronic transfusion therapy (CTT) and outcome.Methods: A descriptive retrospective study of SCD children with strokes seen at the National Hospital Abuja, Nigeria over a 2.5 year period from January 2009 – June 2012. Data was collected by scrutinizing case files obtained from the hospital medical records unit. Information obtained included demographic data, clinical features, packed cell volume (PCV), brain imaging, long term neurologic deficits, effect of CTT, stroke recurrence and outcome.Results: There were 31 children with strokes among 596 children with SCD documented in the register, giving a prevalence of 5.2%. Twenty six (26) case notes were retrieved. There were 12 males and 14 females, M: F ratio of 0.9:1; mean age was 6.4 years (SD 3.4) range: 1 year 7 months – 14 years; mean PCV at the time of strokes was 21.1% (SD 3.9) range 14 –29%. All (100%) had Haemoglobin SS on electrophoresis. Presentationswere convulsions 18, inability to use limbs 11, weakness of limbs 10; long term neurological deficits were hemiplegia 11, cognition loss 11. Three (3) children had no deficits. Brain imaging (Computed Tomography Scan and Magnetic Resonance Imaging) done in 16 (61.5%) children showed cerebral atrophy in 10, acute cerebral infarcts in 9, chronic cerebral infarcts in 6, acute intra cranial haemorrhage in 1 and normal imagings in 4 children. Twelve (12) children (46.2%) children had recurrences of stroke ranging in number from 1 to 4, which occurred 6 months to 3 years afterthe initial stroke. There were no statistical significant differences between the children with recurrences of stroke compared to those without regarding the age, sex, weight or PCVs p > 0.05. Fifteen (15) children (57.7%) wereenrolled in CTT. Two (2) out of 7 children (28.6%) that had regular CTT had stroke recurrence; compared to 5 out of 11 children (45.4%) with no CTT (p > 0.05). Four (4) out of 6 (66.7%) children with irregular CTT and 1 of 2 children who stopped CTT had stroke recurrence.Outcome: 17 children were alive, 7 were lost to follow up, 1 died and 1 was referred to another center.Conclusion: Strokes were an important cause of morbidity in Nigerianchildren with SCD, with major long term neurologic deficits. CTT appearedbeneficial in preventing stroke recurrences. Primary prevention strategy by Trans Cranial Doppler ultrasound studies of the cerebral arteries, with the aim of promptly initiating appropriate preventive therapy for stroke is strongly advocated.Key words: Sickle cell disease, Stroke, Children, Chronic Transfusion Therapy

Clinical features of sickle cell disease at altitude

1992 ◽  
Vol 3 (3) ◽  
pp. 260-268 ◽  
Author(s):  
Festus Adzaku ◽  
Stephen Addae ◽  
Samuel Annobil ◽  
Samir Mohammed
Keyword(s):  
Sickle Cell Disease ◽  
Clinical Features ◽  
Sickle Cell ◽  
Cell Disease
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