scholarly journals Screening for iron deficiency in surgical patients based on noninvasive zinc protoporphyrin measurements

Transfusion ◽  
2019 ◽  
Vol 60 (1) ◽  
pp. 62-72
Author(s):  
Christoph Füllenbach ◽  
Philipp Stein ◽  
Patricia Glaser ◽  
Chris Triphaus ◽  
Simone Lindau ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Surgical Patients ◽  
Zinc Protoporphyrin

scholarly journals Prenatal Iron Deficiency and Replete Iron Status Are Associated with Adverse Birth Outcomes, but Associations Differ in Ghana and Malawi

2019 ◽  
Vol 149 (3) ◽  
pp. 513-521 ◽  
Author(s):  
Brietta M Oaks ◽  
Josh M Jorgensen ◽  
Lacey M Baldiviez ◽  
Seth Adu-Afarwuah ◽  
Ken Maleta ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Birth Outcomes ◽  
Regression Models ◽  
Iron Status ◽  
Secondary Data ◽  
Hemoglobin Concentration ◽  
Late Pregnancy ◽  
Zinc Protoporphyrin ◽  
Adverse Birth Outcomes ◽  
Soluble Transferrin Receptor

ABSTRACTBackgroundPrevious literature suggests a U-shaped relation between hemoglobin concentration and adverse birth outcomes. There is less evidence on associations between iron status and birth outcomes.ObjectiveOur objective was to determine the associations of maternal hemoglobin concentration and iron status with birth outcomes.MethodsWe conducted a secondary data analysis of data from 2 cohorts of pregnant women receiving iron-containing nutritional supplements (20–60 mg ferrous sulfate) in Ghana (n = 1137) and Malawi (n = 1243). Hemoglobin concentration and 2 markers of iron status [zinc protoporphyrin and soluble transferrin receptor (sTfR)] were measured at ≤20 weeks and 36 weeks of gestation. We used linear and Poisson regression models and birth outcomes included preterm birth (PTB), newborn stunting, low birth weight (LBW), and small-for-gestational-age.ResultsPrevalence of iron deficiency (sTfR >6.0 mg/L) at enrollment was 9% in Ghana and 20% in Malawi. In early pregnancy, iron deficiency was associated with PTB (9% compared with 17%, adjusted RR: 1.63; 95% CI: 1.14, 2.33) and stunting (15% compared with 23%, adjusted RR: 1.44; 95% CI: 1.09, 1.94) in Malawi but not Ghana, and was not associated with LBW in either country; replete iron status (sTfR <10th percentile) was associated with stunting (9% compared with 15%, adjusted RR: 1.71; 95% CI: 1.06, 2.77) in Ghana, but not PTB or LBW, and was not associated with any birth outcomes in Malawi. In late pregnancy, iron deficiency was not related to birth outcomes in either country and iron-replete status was associated with higher risk of LBW (8% compared with 16%, adjusted RR: 1.90; 95% CI: 1.17, 3.09) and stunting (6% compared with 13%, adjusted RR: 2.14; 95% CI: 1.21, 3.77) in Ghana, but was not associated with birth outcomes in Malawi.ConclusionsThe associations of low or replete iron status with birth outcomes are population specific. Research to replicate and extend these findings would be beneficial. These trials were registered at clinicaltrials.gov as NCT00970866 (Ghana) and NCT01239693 (Malawi).

Detection of iron-deficiency anemia in hospitalized patients by zinc protoporphyrin

1996 ◽  
Vol 244 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Shan S. WongA ◽  
Ala S. Qutishat ◽  
Jason Lange ◽  
Terrie G. Gornet ◽  
L. Maximilian Buja
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Hospitalized Patients ◽  
Deficiency Anemia ◽  
Zinc Protoporphyrin

scholarly journals Zinc Protoporphyrin/Heme Ratios (ZnPP/H) as a Potential Newborn Screen for Iron Deficiency.

2010 ◽  
Vol 83 (Suppl_1) ◽  
pp. 585-585
Author(s):  
Steven Marmer ◽  
Melinda Chen ◽  
Beth Fischer ◽  
Vidya Sridhar ◽  
Sharon Blohowiak ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Zinc Protoporphyrin ◽  
Newborn Screen

Cord Blood Zinc Protoporphyrin/Heme Ratio in Minority Neonates at Risk for Iron Deficiency

2008 ◽  
Vol 153 (1) ◽  
pp. 133-136 ◽  
Author(s):  
Nicole L. Baumann-Blackmore ◽  
Elizabeth Goetz ◽  
Sharon E. Blohowiak ◽  
Olamide Zaka ◽  
Pamela J. Kling
Keyword(s):  
At Risk ◽  
Iron Deficiency ◽  
Cord Blood ◽  
Zinc Protoporphyrin ◽  
Blood Zinc

Effectiveness of Preoperative Iron Supplementation in Major Surgical Patients with Iron Deficiency

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Chris Triphaus ◽  
Leonie Judd ◽  
Patricia Glaser ◽  
Marie H. Goehring ◽  
Elke Schmitt ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Supplementation ◽  
Surgical Patients

Erythrocyte Zinc Protoporphyrin Testing for Iron Deficiency Anemia in Pregnancy

1994 ◽  
Vol 3 (6) ◽  
pp. 275-278
Author(s):  
Lubor Malina ◽  
Stanislav Janous˘ek ◽  
Ladislav Rosa ◽  
Rajmund Porkorny ◽  
Ladislav Pelech
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Zinc Protoporphyrin ◽  
Anemia In Pregnancy ◽  
In Pregnancy

scholarly journals nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse

Blood ◽  
2005 ◽  
Vol 106 (10) ◽  
pp. 3625-3631 ◽  
Author(s):  
Robert S. Ohgami ◽  
Dean R. Campagna ◽  
Brendan Antiochos ◽  
Emily B. Wood ◽  
John J. Sharp ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Uptake ◽  
Genetic Locus ◽  
Failure To Thrive ◽  
Microcytic Anemia ◽  
Zinc Protoporphyrin ◽  
Hematopoietic Stem ◽  
Hypochromic Microcytic Anemia ◽  
Iron Deficient ◽  
Sparse Hair

AbstractHypochromic, microcytic anemias are typically the result of inadequate hemoglobin production because of globin defects or iron deficiency. Here, we describe the phenotypic characteristics and pathogenesis of a new recessive, hypochromic, microcytic anemia mouse mutant, nm1054. Although the mutation nm1054 is pleiotropic, also resulting in sparse hair, male infertility, failure to thrive, and hydrocephaly, the anemia is the focus of this study. Hematologic analysis reveals a moderately severe, congenital, hypochromic, microcytic anemia, with an elevated red cell zinc protoporphyrin, consistent with functional erythroid iron deficiency. However, serum and tissue iron analyses show that nm1054 animals are not systemically iron deficient. From hematopoietic stem cell transplantation and iron uptake studies in nm1054 reticulocytes, we provide evidence that the nm1054 anemia is due to an intrinsic hematopoietic defect resulting in inefficient transferrin-dependent iron uptake by erythroid precursors. Linkage studies demonstrate that nm1054 maps to a genetic locus not previously implicated in microcytic anemia or iron phenotypes.

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