Risk of chikungunya virus transmission associated with European travelers returning from southern Thailand (2008–2015)

Transfusion ◽  
2019 ◽  
Vol 59 (8) ◽  
pp. 2612-2621 ◽  
Author(s):  
Hatsadee Appassakij ◽  
Paiwon Khuntikij ◽  
Khachornsakdi Silpapojakul ◽  
Charuporn Promwong ◽  
Pairaya Rujirojindakul ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Virus Transmission ◽  
Southern Thailand

scholarly journals Sequential Infection of Aedes aegypti Mosquitoes with Chikungunya Virus and Zika Virus Enhances Early Zika Virus Transmission

Insects ◽  
2018 ◽  
Vol 9 (4) ◽  
pp. 177 ◽  
Author(s):  
Tereza Magalhaes ◽  
Alexis Robison ◽  
Michael Young ◽  
William Black ◽  
Brian Foy ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Blood Meal ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Virus Transmission ◽  
Mosquito Vector ◽  
Molecular Aspects ◽  
Virus Interactions ◽  
Sequential Infection

In urban settings, chikungunya, Zika, and dengue viruses are transmitted by Aedes aegypti mosquitoes. Since these viruses co-circulate in several regions, coinfection in humans and vectors may occur, and human coinfections have been frequently reported. Yet, little is known about the molecular aspects of virus interactions within hosts and how they contribute to arbovirus transmission dynamics. We have previously shown that Aedes aegypti exposed to chikungunya and Zika viruses in the same blood meal can become coinfected and transmit both viruses simultaneously. However, mosquitoes may also become coinfected by multiple, sequential feeds on single infected hosts. Therefore, we tested whether sequential infection with chikungunya and Zika viruses impacts mosquito vector competence. We exposed Ae. aegypti mosquitoes first to one virus and 7 days later to the other virus and compared infection, dissemination, and transmission rates between sequentially and single infected groups. We found that coinfection rates were high after sequential exposure and that mosquitoes were able to co-transmit both viruses. Surprisingly, chikungunya virus coinfection enhanced Zika virus transmission 7 days after the second blood meal. Our data demonstrate heterologous arbovirus synergism within mosquitoes, by unknown mechanisms, leading to enhancement of transmission under certain conditions.

scholarly journals Presence of Autoimmune Antibody in Chikungunya Infection

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Wirach Maek-a-nantawat ◽  
Udomsak Silachamroon
Keyword(s):  
Muscle Weakness ◽  
Antinuclear Antibody ◽  
Endemic Area ◽  
Chikungunya Virus ◽  
Specific Treatment ◽  
Close Monitoring ◽  
Southern Thailand ◽  
Arbovirus Infection

Chikungunya infection has recently re-emerged as an important arthropod-borne disease in Thailand. Recently, Southern Thailand was identified as a potentially endemic area for the chikungunya virus. Here, we report a case of severe musculoskeletal complication, presenting with muscle weakness and swelling of the limbs. During the investigation to exclude autoimmune muscular inflammation, high titers of antinuclear antibody were detected. This is the report of autoimmunity detection associated with an arbovirus infection. The symptoms can mimic autoimmune polymyositis disease, and the condition requires close monitoring before deciding to embark upon prolonged specific treatment with immunomodulators.

scholarly journals Molecular Characterization of Chikungunya Virus Isolates From Two Localized Outbreaks During 2014-2019 in Kerala, India

2021 ◽  
Author(s):  
Anukumar Balakrishnan ◽  
Asia Devi Thounaojam ◽  
Aishwarya Babu ◽  
Jijo Koshy ◽  
Nikhil T L ◽  
...  
Keyword(s):  
South African ◽  
Chikungunya Virus ◽  
Novel Mutation ◽  
Indian Subcontinent ◽  
Virus Transmission ◽  
Amino Acid Position ◽  
East Central ◽  
Sequencing Studies ◽  
Central South

Abstract After the 2005-2009 chikungunya epidemic, intermittent outbreaks were reported in many parts of India. The outbreaks were caused by either locally circulating strains or imported viruses. Virus transmission route can be traced by complete genome sequencing studies. We investigated two outbreaks in the year 2014 and 2019 in Kerala, India. The chikungunya virus (CHIKV) was isolated from the samples and whole genome was sequenced for a 2014 isolate and a 2019 isolate. The phylogenetic tree revealed that the isolates formed a separate group with 2019 isolate from Pune, Maharashtra and belonged to the East/ Central/ South African (ECSA) genotype, Indian subcontinent sub lineage of Indian Ocean Lineage (IOL). A novel mutation at amino acid position 76 of E2 gene was observed in the group. The phylogenetic results suggest that the outbreaks might have caused by a virus, which has been circulating in India since 2014. Furthermore a detailed study is necessary to find out the evolution of CHIKV in India.

An outbreak of yellow fever with concurrent chikungunya virus transmission in South Kordofan, Sudan, 2005

2008 ◽  
Vol 102 (12) ◽  
pp. 1247-1254 ◽  
Author(s):  
L. Hannah Gould ◽  
Magdi S. Osman ◽  
Eileen C. Farnon ◽  
Kevin S. Griffith ◽  
Marvin S. Godsey ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Chikungunya Virus ◽  
Virus Transmission ◽  
South Kordofan

scholarly journals Bridging the Gap Between Experimental Data and Model Parameterization for Chikungunya Virus Transmission Predictions

2016 ◽  
Vol 214 (suppl 5) ◽  
pp. S466-S470 ◽  
Author(s):  
Rebecca C. Christofferson ◽  
Christopher N. Mores ◽  
Helen J. Wearing
Keyword(s):  
Experimental Data ◽  
Chikungunya Virus ◽  
Virus Transmission ◽  
Model Parameterization

scholarly journals Defining the Risk of Zika and Chikungunya Virus Transmission in Human Population Centers of the Eastern United States

2017 ◽  
Vol 11 (1) ◽  
pp. e0005255 ◽  
Author(s):  
Carrie A. Manore ◽  
Richard S. Ostfeld ◽  
Folashade B. Agusto ◽  
Holly Gaff ◽  
Shannon L. LaDeau
Keyword(s):  
United States ◽  
Human Population ◽  
Chikungunya Virus ◽  
Virus Transmission ◽  
Eastern United States

scholarly journals Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential

2014 ◽  
Vol 281 (1792) ◽  
pp. 20141078 ◽  
Author(s):  
Karima Zouache ◽  
Albin Fontaine ◽  
Anubis Vega-Rua ◽  
Laurence Mousson ◽  
Jean-Michel Thiberge ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Environmental Variability ◽  
Vector Competence ◽  
Virus Transmission ◽  
Mosquito Population ◽  
Mosquito Vector ◽  
Human Pathogens ◽  
Public Health Importance ◽  
Transmission Potential ◽  
Vector Borne Diseases

Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic and environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently and may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains and two ambient temperatures (20°C and 28°C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain and temperature. Such genotype-by-genotype-by-environment (G × G × E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens and environmental factors to accurately assess the potential of vector-borne diseases to emerge.

scholarly journals Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

2012 ◽  
Vol 6 (07) ◽  
pp. 563-571 ◽  
Author(s):  
Priyanka Singh ◽  
Veena Mittal ◽  
Moshahid A Rizvi ◽  
Dipesh Bhattacharya ◽  
Mala Chhabra ◽  
...  
Keyword(s):  
South African ◽  
Chikungunya Virus ◽  
South India ◽  
Indian Subcontinent ◽  
Virus Transmission ◽  
Central India ◽  
Nucleotide Sequencing ◽  
East Central ◽  
Northern India ◽  
Central South

Introduction: Re-emergence of chikungunya virus in South India after a gap of 32 years in 2006 affected over a million people in the Indian subcontinent. We kept a close vigil over the emerging trend of this virus between 2006-2010 with a view to establish the identity of the circulating genotype(s) and to determine the route of virus transmission in different parts of India. Methodology: Nucleotide sequencing of the E1 gene region from 36 strains of chikungunya virus from three states in northern India was performed for this present study. Forty-four previously reported E1 sequences, retrieved from the global genome data base were used for making a phylogenetic tree. Results: BLAST search revealed 99% homology of the northern Indian strains of the 2006-2010 outbreak with the Reunion Island isolates of 2006. Northern Indian strains of this study clustered with the East Central South African (ECSA) genotype. Conclusions: Findings indicate that the currently circulating strain of chikungunya virus in northern India had its origin from the 2006 epidemic strain of South India that moved toward northern India via the western central India between 2006-2010 in a phased manner with dominance of the ECSA genotype and not the Asian genotype.

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