Hepatitis E virus blood donor NAT screening: as much as possible or as much as needed?

Transfusion ◽  
2018 ◽  
Vol 59 (2) ◽  
pp. 612-622 ◽  
Author(s):  
T. Vollmer ◽  
J. Diekmann ◽  
C. Knabbe ◽  
J. Dreier
Keyword(s):  
Blood Donor ◽  
Hepatitis E Virus ◽  
Hepatitis E

scholarly journals Hepatitis E virus (HEV) in Scotland: evidence of recent increase in viral circulation in humans

2018 ◽  
Vol 23 (12) ◽  
Author(s):  
Katrina Thom ◽  
Pamela Gilhooly ◽  
Karen McGowan ◽  
Kristen Malloy ◽  
Lisa M Jarvis ◽  
...  
Keyword(s):  
Blood Donor ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Transplant Recipients ◽  
Genotype 3 ◽  
Transplant Patients ◽  
Low Threshold ◽  
Low Levels ◽  
Clade 1 ◽  
Liver Transplant Recipients

Background Previous studies showed low levels of circulating hepatitis E virus (HEV) in Scotland. We aimed to reassess current Scottish HEV epidemiology. Methods: Blood donor samples from five Scottish blood centres, the minipools for routine HEV screening and liver transplant recipients were tested for HEV antibodies and RNA to determine seroprevalence and viraemia. Blood donor data were compared with results from previous studies covering 2004–08. Notified laboratory-confirmed hepatitis E cases (2009-16) were extracted from national surveillance data. Viraemic samples from blood donors (2016) and chronic hepatitis E transplant patients (2014–16) were sequenced. Results: Anti-HEV IgG seroprevalence varied geographically and was highest in Edinburgh where it increased from 4.5% in 2004–08) to 9.3% in 2014–15 (p = 0.001). It was most marked in donors < 35 years. HEV RNA was found in 1:2,481 donors, compared with 1:14,520 in 2011. Notified laboratory-confirmed cases increased by a factor of 15 between 2011 and 2016, from 13 to 206. In 2011–13, 1 of 329 transplant recipients tested positive for acute HEV, compared with six cases of chronic infection during 2014–16. Of 10 sequenced viraemic donors eight and all six patients were infected with genotype 3 clade 1 virus, common in European pigs. Conclusions: The seroprevalence, number of viraemic donors and numbers of notified laboratory-confirmed cases of HEV in Scotland have all recently increased. The causes of this change are unknown, but need further investigation. Clinicians in Scotland, particularly those caring for immunocompromised patients, should have a low threshold for testing for HEV.

scholarly journals A Comparative Study of Assay Performance of Commercial Hepatitis E Virus Enzyme-Linked Immunosorbent Assay Kits in Australian Blood Donor Samples

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Ashish C. Shrestha ◽  
Robert L. P. Flower ◽  
Clive R. Seed ◽  
Susan L. Stramer ◽  
Helen M. Faddy
Keyword(s):  
Blood Donor ◽  
Disease Burden ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Antibody Detection ◽  
Enzyme Linked Immunosorbent Assay ◽  
Poor Agreement ◽  
Igm Elisa ◽  
Assay Performance ◽  
Antibody Elisa

Hepatitis E virus (HEV) is transfusion-transmissible and therefore poses a risk to blood transfusion safety. Seroprevalence studies are useful for estimating disease burden and determining risk factors. Considerable variability in the sensitivity of HEV antibody detection assays exists. This study aimed to compare the performances of commercially available HEV enzyme-linked immunosorbent assays (ELISA) in Australian blood donor samples. Plasma samples that tested positive (n=194) or negative (n=200) for HEV IgG (Wantai HEV IgG ELISA) were selected. Of the 194 HEV IgG positive samples, 4 were positive for HEV IgM (Wantai HEV IgM ELISA). All samples were tested with the MP Diagnostics: HEV IgG ELISA, total (IgG, IgM, and IgA) HEV antibody ELISA, and HEV IgM ELISA. Of the 194 Wantai HEV IgG positive samples, 92 (47%) tested positive with the MP Diagnostics HEV IgG ELISA (κ=0.47) and 126 (65%) with MP Diagnostics total HEV antibody assay (κ=0.65). There was poor agreement between Wantai and MP Diagnostics HEV IgM assays. This study demonstrated poor agreement between the assays tested. These observations are consistent with previous reports demonstrating significant variability between HEV ELISAs, highlighting that results of HEV serology should be interpreted with caution.

scholarly journals Disparities in detection of antibodies against hepatitis E virus in US blood donor samples using commercial assays

Transfusion ◽  
2018 ◽  
Vol 58 (5) ◽  
pp. 1254-1263 ◽  
Author(s):  
Mohammad Zafrullah ◽  
Xiugen Zhang ◽  
Coleen Tran ◽  
Megan Nguyen ◽  
Saleem Kamili ◽  
...  
Keyword(s):  
Blood Donor ◽  
Hepatitis E Virus ◽  
Hepatitis E

Hepatitis E virus infection in the Irish blood donor population

Transfusion ◽  
2016 ◽  
Vol 56 (11) ◽  
pp. 2868-2876 ◽  
Author(s):  
Joan O'Riordan ◽  
Fiona Boland ◽  
Padraig Williams ◽  
Joe Donnellan ◽  
Boris M. Hogema ◽  
...  
Keyword(s):  
Virus Infection ◽  
Blood Donor ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Donor Population

scholarly journals Blood Donor Screening for Hepatitis E Virus in the European Union

2019 ◽  
Vol 46 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Fiona Boland ◽  
Auxiliadora Martinez ◽  
Louise Pomeroy ◽  
Niamh O&apos;Flaherty
Keyword(s):  
European Union ◽  
Blood Donor ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
The European Union ◽  
Donor Screening ◽  
Blood Donor Screening

scholarly journals Effect of Hepatitis E Virus RNA Universal Blood Donor Screening, Catalonia, Spain, 2017‒2020

2022 ◽  
Vol 28 (1) ◽  
Author(s):  
Marta Bes ◽  
Maria I. Costafreda ◽  
Mar Riveiro-Barciela ◽  
Maria Piron ◽  
Angie Rico ◽  
...  
Keyword(s):  
Blood Donor ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Donor Screening ◽  
Virus Rna ◽  
Blood Donor Screening

scholarly journals Knowledge Is Safety: The Time Is Ripe for Hepatitis E Virus Blood Donor Screening

2016 ◽  
Vol 43 (6) ◽  
pp. 425-427 ◽  
Author(s):  
Tanja Vollmer ◽  
Cornelius Knabbe ◽  
Jens Dreier
Keyword(s):  
Blood Donor ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Donor Screening ◽  
Blood Donor Screening

Hepatitis E Virus in LeberBiopsien von Patienten mit akuter Hepatitis unbekannter Ätiologie

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
C Dorloff ◽  
J Hemberger ◽  
M Odenthal ◽  
H Holzmann ◽  
S Aberle ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E
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