scholarly journals Our experience in riboflavin and ultraviolet light pathogen reduction technology for platelets: from platelet production to patient care

Transfusion ◽  
2018 ◽  
Vol 58 (8) ◽  
pp. 1881-1889 ◽  
Author(s):  
Teresa Jimenez-Marco ◽  
Marta Garcia-Recio ◽  
Enrique Girona-Llobera
Keyword(s):  
Patient Care ◽  
Ultraviolet Light ◽  
Platelet Production ◽  
Pathogen Reduction

Effects of riboflavin and ultraviolet light treatment on pathogen reduction and platelets

Transfusion ◽  
2020 ◽  
Vol 60 (11) ◽  
pp. 2647-2654
Author(s):  
Yundi Yin ◽  
Ling Li ◽  
Li Gong ◽  
Haixia Xu ◽  
Zhong Liu
Keyword(s):  
Ultraviolet Light ◽  
Light Treatment ◽  
Pathogen Reduction

Riboflavin-ultraviolet light pathogen reduction treatment does not impact the immunogenicity of murine red blood cells

Transfusion ◽  
2015 ◽  
Vol 56 (4) ◽  
pp. 863-872 ◽  
Author(s):  
Christopher A. Tormey ◽  
Manjula Santhanakrishnan ◽  
Nicole H. Smith ◽  
Jingchun Liu ◽  
Susanne Marschner ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Ultraviolet Light ◽  
Blood Cells ◽  
Reduction Treatment ◽  
Pathogen Reduction

Two pathogen reduction technologies-methylene blue plus light and shortwave ultraviolet light-effectively inactivate hepatitis C virus in blood products

Transfusion ◽  
2012 ◽  
Vol 53 (5) ◽  
pp. 1010-1018 ◽  
Author(s):  
Eike Steinmann ◽  
Ute Gravemann ◽  
Martina Friesland ◽  
Juliane Doerrbecker ◽  
Thomas H. Müller ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Ultraviolet Light ◽  
Blood Products ◽  
Pathogen Reduction

scholarly journals Pathogen reduction with riboflavin and ultraviolet light induces a quasi‐apoptotic state in blood leukocytes

Transfusion ◽  
2019 ◽  
Vol 59 (11) ◽  
pp. 3501-3510 ◽  
Author(s):  
Johnson Q. Tran ◽  
Marcus O. Muench ◽  
John W. Heitman ◽  
Rachael P. Jackman
Keyword(s):  
Ultraviolet Light ◽  
Blood Leukocytes ◽  
Pathogen Reduction

Pathogen reduction of fresh plasma using riboflavin and ultraviolet light: effects on plasma coagulation proteins

Transfusion ◽  
2009 ◽  
Vol 49 (10) ◽  
pp. 2167-2172 ◽  
Author(s):  
Valerie S. Hornsey ◽  
Olive Drummond ◽  
Alex Morrison ◽  
Loraine McMillan ◽  
Ian R. MacGregor ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Plasma Coagulation ◽  
Coagulation Proteins ◽  
Fresh Plasma ◽  
Light Effects ◽  
Pathogen Reduction

Riboflavin and ultraviolet light for pathogen reduction of murine cytomegalovirus in blood products

Transfusion ◽  
2014 ◽  
Vol 55 (4) ◽  
pp. 858-863 ◽  
Author(s):  
Shawn D. Keil ◽  
Natia Saakadze ◽  
Richard Bowen ◽  
James L. Newman ◽  
Sulaiman Karatela ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Murine Cytomegalovirus ◽  
Blood Products ◽  
Pathogen Reduction

Efficacy of apheresis platelets treated with riboflavin and ultraviolet light for pathogen reduction

Transfusion ◽  
2005 ◽  
Vol 45 (8) ◽  
pp. 1335-1341 ◽  
Author(s):  
James P. AuBuchon ◽  
Louise Herschel ◽  
Jill Roger ◽  
Harry Taylor ◽  
Pamela Whitley ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Pathogen Reduction ◽  
Apheresis Platelets

scholarly journals Treatment of blood with a pathogen reduction technology using ultraviolet light and riboflavin inactivates Ebola virus in vitro

Transfusion ◽  
2016 ◽  
Vol 56 ◽  
pp. S6-S15 ◽  
Author(s):  
Andrew P. Cap ◽  
Heather F. Pidcoke ◽  
Shawn D. Keil ◽  
Hilary M. Staples ◽  
Manu Anantpadma ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Ebola Virus ◽  
Pathogen Reduction

Evaluating pathogen reduction of Trypanosoma cruzi with riboflavin and ultraviolet light for whole blood

Transfusion ◽  
2011 ◽  
Vol 52 (2) ◽  
pp. 409-416 ◽  
Author(s):  
Laura Tonnetti ◽  
Aaron M. Thorp ◽  
Heather L. Reddy ◽  
Shawn D. Keil ◽  
Raymond P. Goodrich ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Ultraviolet Light ◽  
Whole Blood ◽  
Pathogen Reduction

Thrombopoietin: From Theory to Reality

1999 ◽  
Vol 82 (08) ◽  
pp. 312-317 ◽  
Author(s):  
Kenneth Kaushansky
Keyword(s):  
Patient Care ◽  
Tissue Distribution ◽  
Cytokine Receptor ◽  
Alternative Route ◽  
Platelet Production ◽  
Cloned Cdna ◽  
And Function

IntroductionThe term thrombopoietin (TPO) was first penned in 1958 to describe the primary regulator of platelet production. Multiple efforts to purify the hormone were unsuccessful throughout the 1970s and 1980s because the protein was scarce and starting materials for purification biochemically complex. Even purification of thrombocytopenic plasma, which is the richest source of TPO, was unsuccessful.1,2 However, the cloning of the proto-oncogene c-mpl 3 opened an alternative route to the identification of TPO. Detailed study of the c-mpl gene revealed that it encoded an orphan hematopoietic cytokine receptor. Its tissue distribution and experiments designed to eliminate its expression suggested that c-mpl encoded the TPO receptor.4,5 In 1994, using three distinct strategies, five separate groups either purified protein or cloned cDNA for TPO.6 This review will focus on the physiology of TPO production and function, concentrating on recent findings that help to explain platelet homeostasis and how our understanding of TPO can translate into better patient care for thrombocytopenic patients.

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