Granulocyte antibodies in male blood donors: can they trigger transfusion-related acute lung injury?

Transfusion ◽  
2018 ◽  
Vol 58 (8) ◽  
pp. 1894-1901 ◽  
Author(s):  
Xuan-Duc Nguyen ◽  
Torsten J. Schulze ◽  
Peter Bugert ◽  
Stephanie Lauber-Härtl ◽  
Monika Schulz-Linkholt ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Blood Donors ◽  
Granulocyte Antibodies

Transfusion-Related Acute Lung Injury Secondary to Biologically Active Mediators

2001 ◽  
Vol 125 (4) ◽  
pp. 523-526
Author(s):  
Susan E. Lenahan ◽  
Ronald E. Domen ◽  
Christopher C. Silliman ◽  
Charles P. Kingsley ◽  
Paula J. Romano
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Distress Syndrome ◽  
Biologically Active ◽  
Blood Components ◽  
Hla Antibodies ◽  
Granulocyte Antibodies ◽  
Priming Activity ◽  
Stored Blood

Abstract Transfusion-related acute lung injury is seen following the transfusion of blood components. The reported incidence is approximately 1 in 2000 transfusions. Clinically, it is similar to adult respiratory distress syndrome. The pathophysiology is unclear but has been attributed to HLA antibodies, granulocyte antibodies, and more recently to biologically active mediators in stored blood components. We report a case with laboratory evidence that supports the role of biologically active mediators in the pathogenesis of transfusion-related acute lung injury. To our knowledge, the case reported here is the first to use lipid extractions of patient samples to determine that lipid-priming activity was present at the time transfusion-related acute lung injury was identified clinically.

Alloexposed blood donors and transfusion-related acute lung injury: a case-referent study

Transfusion ◽  
2011 ◽  
Vol 51 (10) ◽  
pp. 2111-2117 ◽  
Author(s):  
Rutger A. Middelburg ◽  
Daniëlle van Stein ◽  
Femke Atsma ◽  
Johanna C. Wiersum-Osselton ◽  
Leendert Porcelijn ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Blood Donors

scholarly journals The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: implications for a transfusion-related acute lung injury risk reduction strategy

Transfusion ◽  
2009 ◽  
Vol 49 (9) ◽  
pp. 1825-1835 ◽  
Author(s):  
Darrell J. Triulzi ◽  
Steven Kleinman ◽  
Ram M. Kakaiya ◽  
Michael. P. Busch ◽  
Philip J. Norris ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Risk Reduction ◽  
Injury Risk ◽  
Blood Donors ◽  
Previous Pregnancy ◽  
Reduction Strategy ◽  
Risk Reduction Strategy
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