scholarly journals Short-term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study

Transfusion ◽  
2017 ◽  
Vol 58 (3) ◽  
pp. 795-803 ◽  
Author(s):  
Michael Jordi Wilson ◽  
Jan Willem Dekker ◽  
Emma Bruns ◽  
Wernard Borstlap ◽  
Johannes Jeekel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Cancer Patients ◽  
Intravenous Iron ◽  
Term Effect ◽  
Iron Therapy ◽  
Short Term ◽  
Short Term Effect ◽  
Intravenous Iron Therapy ◽  
Colorectal Cancer Patients

scholarly journals Multimorbidity and short-term overall mortality among colorectal cancer patients in Spain: A population-based cohort study

2020 ◽  
Vol 129 ◽  
pp. 4-14
Author(s):  
Miguel A. Luque-Fernandez ◽  
Karen Gonçalves ◽  
Elena Salamanca-Fernández ◽  
Daniel Redondo-Sanchez ◽  
Shing F. Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Cancer Patients ◽  
Population Based ◽  
Short Term ◽  
Colorectal Cancer Patients ◽  
Overall Mortality

Short term outcome for colorectal cancer patients undergoing surgery in Tertiary care center in Eastern India

2021 ◽  
Vol 47 (2) ◽  
pp. e50-e51
Author(s):  
Abhitesh Singh ◽  
Anshul Jain ◽  
Dillip Muduly ◽  
Mahesh Sultania ◽  
Jyoti Ranjan Swain ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Eastern India ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Colorectal Cancer Patients

scholarly journals Oral and Intravenous Iron Therapy Differentially Alter the On- and Off-Tumor Microbiota in Anemic Colorectal Cancer Patients

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1341
Author(s):  
Oliver Phipps ◽  
Hafid O. Al-Hassi ◽  
Mohammed N. Quraishi ◽  
Edward A. Dickson ◽  
Jonathan Segal ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ferrous Sulphate ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Ferric Carboxymaltose ◽  
Β Diversity ◽  
Post Surgery ◽  
Intravenous Iron Therapy

Iron deficiency anemia is a common complication of colorectal cancer and may require iron therapy. Oral iron can increase the iron available to gut bacteria and may alter the colonic microbiota. We performed an intervention study to compare oral and intravenous iron therapy on the colonic tumor-associated (on-tumor) and paired non-tumor-associated adjacent (off-tumor) microbiota. Anemic patients with colorectal adenocarcinoma received either oral ferrous sulphate (n = 16) or intravenous ferric carboxymaltose (n = 24). On- and off-tumor biopsies were obtained post-surgery and microbial profiling was performed using 16S ribosomal RNA analysis. Off-tumor α- and β-diversity were significantly different between iron treatment groups. No differences in on-tumor diversity were observed. Off-tumor microbiota of oral iron-treated patients showed higher abundances of the orders Clostridiales, Cytophagales, and Anaeroplasmatales compared to intravenous iron-treated patients. The on-tumor microbiota was enriched with the orders Lactobacillales and Alteromonadales in the oral and intravenous iron groups, respectively. The on- and off-tumor microbiota associated with intravenous iron-treated patients infers increased abundances of enzymes involved in iron sequestration and anti-inflammatory/oncogenic metabolite production, compared to oral iron-treated patients. Collectively, this suggests that intravenous iron may be a more appropriate therapy to limit adverse microbial outcomes compared to oral iron.

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