scholarly journals Postdonation iron replacement for maintaining iron stores in female whole blood donors in routine donor practice: results of two feasibility studies in Australia

Transfusion ◽  
2017 ◽  
Vol 57 (8) ◽  
pp. 1922-1929 ◽  
Author(s):  
Sant-Rayn Pasricha ◽  
Denese C. Marks ◽  
Hannah Salvin ◽  
Tania Brama ◽  
Anthony J. Keller ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Feasibility Studies ◽  
Iron Stores ◽  
Iron Replacement

scholarly journals FinDonor 10 000 study: A cohort to identify iron depletion and factors affecting it in Finnish blood donors

2018 ◽  
Author(s):  
Jukka Partanen ◽  
Pia Niittymäki ◽  
Nina Nikiforow ◽  
Elina Palokangas ◽  
Muriel Lobier ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Iron Status ◽  
Time Lag ◽  
Time Of Day ◽  
Cool Temperature ◽  
Factors Affecting ◽  
Iron Stores ◽  
Increased Risk ◽  
Donation Frequency

AbstractBackground and ObjectivesThere is increasing evidence that frequent blood donation depletes the iron stores of some blood donors. The FinDonor 10 000 study was set up to study iron status and factors affecting iron stores in Finnish blood donors. In Finland, iron supplementation for at-risk groups has been in place since the 1980’s.Material and Methods2584 blood donors (N= 8003 samples) were recruited into the study alongside the standard donation at three donation sites in the capital region of Finland between 5/2015 and 12/2017. All participants were asked to fill out a questionnaire about their health and lifestyle. Blood samples were collected from the sample pouch of whole blood collection set, kept in cool temperature and processed centrally. Whole blood count, CRP, ferritin and sTFR were measured from the samples and DNA was isolated for GWAS studies.ResultsParticipant demographics, albeit in general similar to the general blood donor population in Finland, indicated some bias toward older and more frequent donors. Participation in the study increased median donation frequency of the donors. Analysis of the effect of time lag from the sampling to the analysis and the time of day when sample was drawn revealed small but significant time-dependent changes.ConclusionThe FinDonor cohort now provides us with tools to identify potential donor groups at increased risk of iron deficiency as factors explaining this risk. The increase in donation frequency during the study suggests that scientific projects can be used to increase the commitment of blood donors.

scholarly journals Ferritin trajectories over repeated whole blood donations: results from the FIND+ study

2021 ◽  
Author(s):  
Sara Moazzen ◽  
Maike sweegers ◽  
Brois Hogema ◽  
Trynke Hoekstra ◽  
Katja van den Hurk
Keyword(s):  
Whole Blood ◽  
Mixed Models ◽  
Iron Supplementation ◽  
Blood Donors ◽  
Ferritin Level ◽  
Growth Mixture Models ◽  
Iron Stores ◽  
Growth Mixture ◽  
Observational Cohort

Abstract Background: Whole blood donors lose approximately 200-250 mg of iron per donation. Depending on post-donation erythropoiesis, available iron stores, and iron absorption rates, optimal donation intervals may differ between donors. This project aims to define subpopulations of donors with different ferritin trajectories over repeated donations. Methods: Ferritin levels of 300 new whole blood donors were measured from stored (lookback) samples from each donation over a two-year period in an observational cohort study. Latent classes of ferritin level trajectories were investigated using growth mixture models for male and female donors, separately. Associations of ferritin levels with subsequent iron deficiency and/or low haemoglobin were assessed with generalized linear mixed models. Results: In both genders two groups of donors were identified using group-based trajectory modelling. Ferritin levels showed rather linear reductions among 42.9% of male donors and 87.7% of female donors. For the remaining groups of donors, steeper declines in ferritin levels were observed. Ferritin levels at baseline and the end of follow-up varied greatly between groups. Conclusion: Repeated ferritin measurements show depleting iron stores in all new whole blood donors, the level at which mainly depends on baseline ferritin levels. Tailored, less intensive donation strategies might help to prevent low iron in donors, and could be supported with ferritin monitoring and/or iron supplementation.

Superdonors Have Decreased Iron Stores but Can Repeatedly Donate Whole Blood through Use of Iron Supplements and Decreased Serum Hepcidin Concentration.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2887-2887
Author(s):  
Alan E. Mast ◽  
Tisha Foster ◽  
Holly L. Pinder ◽  
Craig A. Beczkiewicz ◽  
Daniel B. Bellissimo ◽  
...  
Keyword(s):  
Polycythemia Vera ◽  
Whole Blood ◽  
Blood Donors ◽  
Iron Absorption ◽  
Blood Donation ◽  
C282y Mutation ◽  
Iron Supplements ◽  
Expected Frequency ◽  
Iron Stores ◽  
Serum Hepcidin

Abstract Examination of the low hematocrit (HCT) deferral rates in whole blood donors based on gender/menstrual status and donation intensity unexpectedly revealed that low HCT deferral rates level off and even begin to decrease in frequent donors (>8 donations in 2 years) suggesting that frequent blood donors are a self-selected population possessing either behavioral or biochemical characteristics that allow greater iron absorption than the general population. To define these characteristics, 138 donors (101 male, 37 female, 136 Caucasian) that had donated 13 times in a 2-year period (“superdonors”) completed a questionnaire and had a blood sample analyzed for ferritin, hepcidin and HFE and JAK-2 genotypes. Ferritin was 31.0±20.3 ug/L for males and 25.2±14.8 ug/L for females. Two-thirds of both men and women had ferritin below 30 ug/L indicating that most have reduced iron stores. Average ferritin was ∼15 ug/L higher in donors taking multiple vitamins with iron or iron supplements than in those who did not take them. Hepcidin is an iron regulatory hormone that negatively regulates intestinal iron absorption. Serum hepcidin levels were determined using a liquid chromatography tandem mass spectrometry assay. The normal serum hepcidin concentration using this assay is 8–11 ng/ml [Blood110:1048 (2007)]. Serum hepcidin was greatly decreased in superdonors (males 2.9±5.4 ng/ml; females 2.8±2.7 ng/ml) and 55 had no detectable hepcidin (<1 ng/ml), suggesting that superdonors absorb maximal amounts of intestinal iron. The C282Y mutation in the HFE gene has been linked to unregulated iron absorption and the development of hemochromatosis. This mutation was analyzed to determine if heterozygosity is present at greater than expected frequency in superdonors. It is present in 21 (15.2%) of the superdonors. This is higher than the reported frequency of 10–12% in Caucasians but did not reach statistical significance. The JAK-2 mutation is strongly associated with polycythemia vera and other myeloproliferative disorders. None of the superdonors had this mutation. In summary, superdonors are able to frequently donate whole blood with a lower than expected frequency of low HCT deferral despite having very low iron stores. Many, but not all, superdonors take either multiple vitamins with iron or an iron supplement that partially accounts for their ability to repeatedly meet the HCT requirement for whole blood donation. A key biochemical characteristic of superdonors that also contributes to their ability to repeatedly donate whole blood is greatly reduced serum hepcidin concentration that allows maximal intestinal iron absorption. Genetic analyses revealed that there is a trend towards an increased prevalence of heterozygosity for the C282Y mutation that may allow some superdonors to efficiently absorb intestinal iron and donate frequently without low HCT deferral, but no evidence for presence of the JAK-2 mutation indicating that undiagnosed polycythemia vera is not a common cause for successful repeated blood donation by superdonors.

International Forum on Mitigation Strategies to Prevent Faint and Pre‐faint Adverse Reactions in Whole Blood Donors: Responses

Vox Sanguinis ◽  
2021 ◽  
Vol 116 (3) ◽  
Author(s):  
Mindy Goldman ◽  
Mary Townsend ◽  
Karin Magnussen ◽  
Miquel Lozano ◽  
Lise Sofie H. Nissen‐Meyer ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Adverse Reactions ◽  
Mitigation Strategies ◽  
International Forum

Improved safety for young whole blood donors with new selection criteria for total estimated blood volume

Transfusion ◽  
2011 ◽  
Vol 51 (7) ◽  
pp. 1522-1531 ◽  
Author(s):  
Anne F. Eder ◽  
Beth A. Dy ◽  
Jean M. Kennedy ◽  
Jaime Perez ◽  
Patricia Demaris ◽  
...  
Keyword(s):  
Blood Volume ◽  
Whole Blood ◽  
Selection Criteria ◽  
Blood Donors

Fear is associated with attrition of first‐time whole blood donors: A longitudinal examination of donor confidence and attitude as potential mediators

Transfusion ◽  
2021 ◽  
Author(s):  
Christopher R. France ◽  
Janis L. France ◽  
Lina K. Himawan ◽  
Louisa Duffy ◽  
Debra A. Kessler ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
First Time ◽  
Longitudinal Examination

scholarly journals Estimation of Serum Ferritin Levels in Blood Donors and its Association with Frequency of Blood Donation and Blood Indices

2021 ◽  
Author(s):  
Amrita S Kumar ◽  
A Geetha ◽  
Jim Joe ◽  
Arun Mathew Chacko
Keyword(s):  
Serum Ferritin ◽  
Blood Donors ◽  
Blood Donation ◽  
Iron Status ◽  
Previous History ◽  
P Value ◽  
Blood Indices ◽  
Iron Stores ◽  
Group I ◽  
History Of

Introduction: Blood donation is one of the most significant contributions that a person can make towards the society. A donor generally donates maximum 450 mL of blood at the time of donation. If 450 mL of blood is taken in a donation, men lose 242±17 mg and women lose 217±11 mg of iron. Hence, adequate iron stores are very important in maintenance of the donor’s health. Aim: To assess the influence of frequency of blood donation on iron levels of blood donors by estimating Haemoglobin (Hb) and other blood indices which reflect iron status of blood and serum ferritin which reflects body iron stores. Materials and Methods: The present study was a cross-sectional analytical study, conducted on 150 blood donors, 18-40 years of age presenting to the Blood Bank in Government Medical College, Kottayam, Kerala, India, between December 2016 to December 2017. Total of 150 donors were divided into four groups according to the number of donations per year. Group I were the first time donors with no previous history of blood donation, Group II- included those with history of donation once in the previous year, Group III- those donors with history of donation twice in the previous year and Group IV- those having history of donation thrice in the previous year. Six ml of whole blood collected from each donor, two ml was used for estimating Haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hb (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC) in haematology analyser. Serum separated from remaining four mL of blood underwent ferritin analysis by Chemiluminescence Immunoassay (CLIA) method. Iron stores were considered normal at serum ferritin value from 23.9-336ng/mL in males and 11-307ng/mL in females. Statistical analysis was performed in Statistical Package for the Social Sciences (SPSS) version 16.0. Analysis of Variance (ANOVA) test and Pearson correlation test were used to find association between various parameters and collected data. The p-value <0.05 was considered as statistically significant. Results: There was no significant correlation between serum ferritin level and frequency of blood donation. MCH, MCHC showed significant association (p-value 0.039 and 0.007, respectively) with frequency of blood donation. Low positive correlation was seen between Hb and PCV with serum ferritin levels (r=0.381, p-value <0.001 and r=0.354, p-value <0.001, respectively). Conclusion: There is no significant association between frequency of blood donation and serum ferritin levels.

Prediction of hemoglobin levels in whole blood donors: how to model donation history

Transfusion ◽  
2013 ◽  
Vol 54 (3pt2) ◽  
pp. 925-932 ◽  
Author(s):  
A. Mireille Baart ◽  
Yvonne Vergouwe ◽  
Femke Atsma ◽  
Karel G.M. Moons ◽  
Wim L.A.M. de Kort
Keyword(s):  
Whole Blood ◽  
Blood Donors
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