Relative efficacy of tranexamic acid and preoperative anemia treatment for reducing transfusions in total joint arthroplasty

Transfusion ◽  
2016 ◽  
Vol 57 (3) ◽  
pp. 622-629 ◽  
Author(s):  
Joseph F. Styron ◽  
Alison K. Klika ◽  
Caleb R. Szubski ◽  
Deborah Tolich ◽  
Wael K. Barsoum ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Total Joint Arthroplasty ◽  
Joint Arthroplasty ◽  
Relative Efficacy ◽  
Preoperative Anemia ◽  
Anemia Treatment

scholarly journals The bactericidal effect of vancomycin is not altered by tranexamic acid, adrenalin, dexamethasone, or lidocaine in vitro

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christiane Schwerdt ◽  
Eric Röhner ◽  
Sabrina Böhle ◽  
Benjamin Jacob ◽  
Georg Matziolis
Keyword(s):  
Staphylococcus Aureus ◽  
Tranexamic Acid ◽  
Total Joint Arthroplasty ◽  
Staphylococcus Epidermidis ◽  
Joint Infection ◽  
Bactericidal Effect ◽  
Joint Arthroplasty ◽  
Zone Of Inhibition ◽  
Agar Diffusion Test

AbstractOne of the most challenging complications of total knee arthroplasty (TKA) is periprosthetic joint infection (PJI). There is growing evidence of a good anti-infective effect of intrawound vancomycin powder in total joint arthroplasty. At the same time, various different locally applied substances have become popular in total joint arthroplasty. The objective of this study was therefore to investigate a possible inhibition of the bactericidal effect of vancomycin by tranexamic acid, adrenalin, lidocaine, or dexamethasone. The bactericidal effect of vancomycin was quantified using the established method of the agar diffusion test. The plates were incubated with Staphylococcus aureus or Staphylococcus epidermidis and four wells were stamped out. The wells were filled with vancomycin alone, the tested substance alone or a mixture of the two. The fourth well remained empty as a control. The plates were incubated overnight at 37 °C and the zone of inhibition in each field was measured on the next day. All tests were run three times for each pathogen and mean values and standard deviations of the measurements were calculated. Differences between the substances were tested using the t-test at a level of significance of 0.05. The bacterial growth was homogeneous on all plates. The baseline value for the zone of inhibition of vancomycin was on average 6.2 ± 0.4 mm for Staphylococcus aureus and 12 ± 0.3 mm for Staphylococcus epidermidis. In all other substances, no inhibition was detected around the well. The combination of vancomycin and each other substance did not show any different result compared to vancomycin alone. The bactericidal effect of vancomycin on staphylococci is not altered by tranexamic acid, adrenalin, dexamethasone, or lidocaine in vitro.

scholarly journals Letter to the Editor on “The Safety of Tranexamic Acid in Total Joint Arthroplasty: A Direct Meta-Analysis”

2018 ◽  
Vol 33 (10) ◽  
pp. 3365-3368.e1 ◽  
Author(s):  
Xiang-Dong Wu ◽  
Ke-Jia Hu ◽  
Ya-Ying Sun ◽  
Yu Chen ◽  
Wei Huang
Keyword(s):  
Tranexamic Acid ◽  
Total Joint Arthroplasty ◽  
Meta Analysis ◽  
Joint Arthroplasty ◽  
Letter To The Editor

In the Era of Tranexamic Acid, are Type and Screens for Primary Total Joint Arthroplasty Obsolete?

2020 ◽  
Vol 35 (9) ◽  
pp. 2363-2366 ◽  
Author(s):  
George L. Vestermark ◽  
Taylor M. Rowe ◽  
John R. Martin ◽  
Susan M. Odum ◽  
Bryan D. Springer ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Total Joint Arthroplasty ◽  
Joint Arthroplasty

Tranexamic acid in total joint arthroplasty

2016 ◽  
Vol 86 (4) ◽  
pp. 219-220
Author(s):  
Marinus D. J. Stowers ◽  
Jacob T. Munro ◽  
Andrew G. Hill
Keyword(s):  
Tranexamic Acid ◽  
Total Joint Arthroplasty ◽  
Joint Arthroplasty
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