Spur cell hemolytic anemia in liver failure

Transfusion ◽  
2016 ◽  
Vol 56 (4) ◽  
pp. 787-788 ◽  
Author(s):  
Colin H. Murphy ◽  
Shweta Jain ◽  
Daniel E. Sabath ◽  
Gurkamal S. Chatta ◽  
John R. Hess
Keyword(s):  
Liver Failure ◽  
Hemolytic Anemia

Hemolytic anemia in protoporphyria: Possible precipitating role of liver failure and photic stress

1992 ◽  
Vol 39 (3) ◽  
pp. 202-207 ◽  
Author(s):  
Nigel S. Key ◽  
Jeffrey M. Rank ◽  
Deborah Freese ◽  
Joseph R. Bloomer ◽  
Dale E. Hammerschmidt
Keyword(s):  
Liver Failure ◽  
Hemolytic Anemia

scholarly journals Marked Hyperferritinemia Does Not Predict for Hemophagocytic Lymphohistiocytosis (HLH) in the Adult Population

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4951-4951
Author(s):  
Alison M Schram ◽  
Ann Mullally ◽  
Federico Campigotto ◽  
Annemarie E Fogerty ◽  
Elena Massarotti ◽  
...  
Keyword(s):  
Renal Failure ◽  
Linear Regression ◽  
Iron Overload ◽  
Liver Failure ◽  
Hemolytic Anemia ◽  
Serum Ferritin ◽  
Hematologic Malignancy ◽  
Pediatric Population ◽  
Adult Population ◽  
Stepwise Linear Regression

Abstract Introduction Markedly elevated serum ferritin levels are often thought to be exclusively seen in rheumatologic and inflammatory disorders including adult-onset Still’s disease (AOSD), macrophage activation syndrome (MAS), and hemophagocytic lymphohistocytosis (HLH). In the pediatric population, ferritin >10,000 µg/L is highly sensitive and specific for HLH (Allen CE, et al. Pediatr Blood Cancer. 2008). In order to determine what conditions are associated with profoundly elevated ferritin levels in the adult population, we performed a retrospective analysis of patients with serum ferritin >50,000 µg/L in a large academic healthcare system. Methods Using a centralized clinical data registry, we searched for all patients at Brigham and Women’s Hospital (BWH), Massachusetts General Hospital (MGH), and Faulkner Hospital (FH) who had serum ferritin levels >50,000 µg/L between 8/1/1988-1/29/2014 for BWH and MGH, and 8/9/1995-1/29/2014 for FH. For patients who had multiple ferritin levels >50,000 µg/L, we used the highest value. Patients <18 years old were excluded and the medical charts of the remaining patients were manually reviewed. We collected demographic data including age, race, and gender. Each patient was categorized as having HLH, MAS, rheumatologic/inflammatory disorder, hematologic malignancy, solid tumor, renal failure, sepsis/infection, liver failure, iron overload, hemolytic anemia, or none of these conditions. Causes were not considered mutually exclusive. Univariate and multivariable linear regressions were used to evaluate the association of those factors with ferritin levels modeled using the logarithmic transformation of the actual ferritin levels. The Wilcoxon rank sum test was also performed along with the univariate analysis. Those covariates statistically significant at an alpha level of 0.2 were included in the multivariable stepwise linear regression model. In the multivariable analysis, a p-value <0.05 was considered statistically significant. Results We identified 113 total patients with ferritin levels above 50,000 µg/L at BWH, MGH, and FH during the study period. The patients ranged from 20 years old to 88 years old (mean 56 years old). The majority of patients were male (58%). The racial distribution included White (75%), Black (16%), Hispanic (4%), Asian (2%), and unknown (3%). Ferritin levels ranged from 50,129 to 439,500 µg/L with a median of 82,930 µg/L (notably, two patients had ferritin levels more than the assay of >100,000 µg/L). The characteristics of the patients with ferritin levels >50,000 µg/L included renal disease (65%), liver disease (54%), sepsis/infection (46%), hematologic malignancy (33%), rheumatologic/inflammatory conditions (18%), HLH (17%), iron overload (11%), hemolytic anemia (4%), solid malignancy (4%), and MAS (3%) (table 1). The majority of patients with HLH were thought to have secondary HLH triggered by a malignancy (9/19) or infection (6/19), with the minority having no clear precipitating cause (4/19). All 9 patients with malignancy-associated HLH had a hematologic malignancy (4/9 had T-cell lymphoma, 3/9 had DLBCL, 1/9 had transformed AML, and 1/9 had erythroleukemia). The stepwise linear regression showed that presence of hemolytic anemia was the only variable associated with a differential ferritin level (β=1.51, p=0.03). Conclusions Extremely elevated ferritin levels are associated with many conditions and most often seen in patients with hematologic malignancies, liver failure, and renal failure. Although less common in our cohort, those patients with hemolytic anemia had higher ferritin levels compared to patients without hemolytic anemia. In contrast to what has been described in the pediatric population, there does not appear to be any value above which ferritin is specific for HLH in the adult population. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Rapid Identification of Biallelic SPTB Mutation in a Neonate with Severe Congenital Hemolytic Anemia and Liver Failure

2020 ◽  
Vol 11 (1) ◽  
pp. 50-55
Author(s):  
Christopher M. Richmond ◽  
Sally Campbell ◽  
Hee W. Foo ◽  
Sebastian Lunke ◽  
Zornitza Stark ◽  
...  
Keyword(s):  
Liver Failure ◽  
Hemolytic Anemia ◽  
Rapid Identification ◽  
Congenital Hemolytic Anemia

scholarly journals Acute liver failure with hemolytic anemia in children with Wilson’s disease: Genotype-phenotype correlations?

2021 ◽  
Vol 13 (10) ◽  
pp. 1428-1438
Author(s):  
Tudor Lucian Pop ◽  
Alina Grama ◽  
Ana Cristina Stefanescu ◽  
Claudia Willheim ◽  
Peter Ferenci
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hemolytic Anemia ◽  
Wilson’S Disease ◽  
Wilson's Disease

scholarly journals Infectious Mononucleosis Causing Acute Liver Failure and Hemolytic Anemia in a Patient with Underlying Hereditary Hemochromatosis

2020 ◽  
Vol 13 (3) ◽  
pp. 1232-1238
Author(s):  
Mark Forsberg ◽  
Mark Galan ◽  
Joshua Kra
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hemolytic Anemia ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Genetic Disorder ◽  
Hereditary Hemochromatosis ◽  
Barr Virus ◽  
Immune Hemolytic Anemia ◽  
Epstein Barr

Infectious mononucleosis is a largely benign disease process that occurs secondary to infection with the Epstein-Barr virus. However, it can also present with more serious complications, including auto-immune hemolytic anemia and acute liver failure. Hereditary hemochromatosis is a genetic disorder that leads to organ damage via increased iron uptake and deposition. This case report describes a 25-year-old man who presented with acute liver failure and severe hemolytic anemia. Workup revealed that not only did he have a rare presentation of Epstein-Barr virus-induced acute liver failure and C<sub>3</sub>-positive IgG-negative hemolytic anemia, he also had previously undiagnosed hereditary hemochromatosis. This combined presentation of these pathologies presents a unique opportunity to study their interaction and possible synergistic pathophysiology. Furthermore, the evolving understanding of the disease mechanisms behind these disease processes is described.

scholarly journals An autopsy case of Wilson's disease complicating fatal acute liver failure and hemolytic anemia after discontinuation of therapy.

Kanzo ◽  
1992 ◽  
Vol 33 (8) ◽  
pp. 649-653
Author(s):  
Yasuhiro ASAHINA ◽  
Naoya SAKAMOTO ◽  
Toshinori KAMIYAMA ◽  
Junichi TAZAWA ◽  
Masanobu NISHIMURA ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hemolytic Anemia ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Autopsy Case

scholarly journals Recurrent Hemolytic Anemia as an Inaugural Manifestation of Wilson Disease in Children: A Case Report

2019 ◽  
Vol 9 (1) ◽  
pp. 5-6
Author(s):  
Ouidad Louachama ◽  
Aicha Bourrahouat ◽  
Ibtissam Khattou ◽  
Imane Ait Sab ◽  
Mohamed Sbihi
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Liver Failure ◽  
Hemolytic Anemia ◽  
Wilson Disease ◽  
Wilson’S Disease ◽  
Copper Metabolism ◽  
Wilson's Disease ◽  
Brain Disorders

Wilson disease (WD) is a disorder of copper metabolism. Liver and brain disorders are the main presentations, hemolytic anemia in WD is a rare inaugural symptom. We report a case of a child who developed recurrent hemolytic anemia associated with liver failure in the second hemolysis episode as the first manifestation of WD. Wilson's disease is not exceptional in children with hemolytic anemia, but another differential diagnosis must be excluded.

Sign in / Sign up

Export Citation Format

Share Document