p38MAPK is involved in apoptosis development in apheresis platelet concentrates after riboflavin and ultraviolet light treatment

Transfusion ◽  
2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Zhongming Chen ◽  
Peter Schubert ◽  
Brankica Culibrk ◽  
Dana V. Devine
Keyword(s):  
Ultraviolet Light ◽  
Light Treatment ◽  
Platelet Concentrates

Riboflavin and ultraviolet light treatment potentiates vasodilator-stimulated phosphoprotein Ser-239 phosphorylation in platelet concentrates during storage

Transfusion ◽  
2011 ◽  
Vol 52 (2) ◽  
pp. 397-408 ◽  
Author(s):  
Peter Schubert ◽  
Brankica Culibrk ◽  
Danielle Coupland ◽  
Ken Scammell ◽  
Maria Gyongyossy-Issa ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Light Treatment ◽  
Platelet Concentrates

Efficiency of riboflavin and ultraviolet light treatment against high levels of biofilm-derivedStaphylococcus epidermidisin buffy coat platelet concentrates

Vox Sanguinis ◽  
2017 ◽  
Vol 112 (5) ◽  
pp. 408-416 ◽  
Author(s):  
M. Taha ◽  
B. Culibrk ◽  
M. Kalab ◽  
P. Schubert ◽  
Q.-L. Yi ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Light Treatment ◽  
Buffy Coat ◽  
Platelet Concentrates

scholarly journals Complete Inactivation of Blood Borne Pathogen Trypanosoma cruzi in Stored Human Platelet Concentrates and Plasma Treated With 405 nm Violet-Blue Light

2020 ◽  
Vol 7 ◽  
Author(s):  
Katarzyna I. Jankowska ◽  
Rana Nagarkatti ◽  
Nirmallya Acharyya ◽  
Neetu Dahiya ◽  
Caitlin F. Stewart ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Human Plasma ◽  
Blue Light ◽  
Chagas Disease ◽  
Light Treatment ◽  
Platelet Concentrates ◽  
Complete Inactivation ◽  
Pathogen Reduction ◽  
Biochemical Indices

The introduction of pathogen reduction technologies (PRTs) to inactivate bacteria, viruses and parasites in donated blood components stored for transfusion adds to the existing arsenal toward reducing the risk of transfusion-transmitted infectious diseases (TTIDs). We have previously demonstrated that 405 nm violet-blue light effectively reduces blood-borne bacteria in stored human plasma and platelet concentrates. In this report, we investigated the microbicidal effect of 405 nm light on one important bloodborne parasite Trypanosoma cruzi that causes Chagas disease in humans. Our results demonstrated that a light irradiance at 15 mWcm−2 for 5 h, equivalent to 270 Jcm−2, effectively inactivated T. cruzi by over 9.0 Log10, in plasma and platelets that were evaluated by a MK2 cell infectivity assay. Giemsa stained T. cruzi infected MK2 cells showed that the light-treated parasites in plasma and platelets were deficient in infecting MK2 cells and did not differentiate further into intracellular amastigotes unlike the untreated parasites. The light-treated and untreated parasite samples were then evaluated for any residual infectivity by injecting the treated parasites into Swiss Webster mice, which did not develop infection even after the animals were immunosuppressed, further demonstrating that the light treatment was completely effective for inactivation of the parasite; the light-treated platelets had similar in vitro metabolic and biochemical indices to that of untreated platelets. Overall, these results provide a proof of concept toward developing 405 nm light treatment as a pathogen reduction technology (PRT) to enhance the safety of stored human plasma and platelet concentrates from bloodborne T. cruzi, which causes Chagas disease.

Corneal endothelial safety after ultraviolet light treatment of the light-adjustable intraocular lens

2011 ◽  
Vol 37 (2) ◽  
pp. 324-327 ◽  
Author(s):  
Alejandro Lichtinger ◽  
Christopher A. Sandstedt ◽  
Karina Padilla ◽  
Daniel M. Schwartz ◽  
Arturo S. Chayet
Keyword(s):  
Ultraviolet Light ◽  
Intraocular Lens ◽  
Light Treatment

scholarly journals Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light

Transfusion ◽  
2005 ◽  
Vol 45 (4) ◽  
pp. 580-590 ◽  
Author(s):  
Lily Lin ◽  
Carl V. Hanson ◽  
Harvey J. Alter ◽  
Valérie Jauvin ◽  
Kristen A. Bernard ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Platelet Concentrates ◽  
Long Wavelength

Inactivation ofPlasmodiumspp. in plasma and platelet concentrates using riboflavin and ultraviolet light

Transfusion ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Shawn D. Keil ◽  
Patti Kiser ◽  
James J. Sullivan ◽  
Amy S. Kong ◽  
Heather L. Reddy ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Platelet Concentrates

Effects of riboflavin and ultraviolet light treatment on pathogen reduction and platelets

Transfusion ◽  
2020 ◽  
Vol 60 (11) ◽  
pp. 2647-2654
Author(s):  
Yundi Yin ◽  
Ling Li ◽  
Li Gong ◽  
Haixia Xu ◽  
Zhong Liu
Keyword(s):  
Ultraviolet Light ◽  
Light Treatment ◽  
Pathogen Reduction
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