Treatment with fibrinogen γ-chain peptide-coated, adenosine 5′-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia

Transfusion ◽  
2014 ◽  
Vol 55 (2) ◽  
pp. 314-325 ◽  
Author(s):  
Kohsuke Hagisawa ◽  
Kahoko Nishikawa ◽  
Rempei Yanagawa ◽  
Manabu Kinoshita ◽  
Mami Doi ◽  
...  
Keyword(s):  
Hemostatic Agent ◽  
Liver Bleeding

EFFICACY OF NEW TOPICAL HEMOSTATIC AGENT ALUFERRUM IN A RAT TRAUMATIC TRAUMATIC LIVER BLEEDING MODEL.

Shock ◽  
2004 ◽  
Vol 21 (Supplement) ◽  
pp. 16
Author(s):  
I. Kremenevskiy ◽  
N. Melnova ◽  
A. Cheholskiy ◽  
V. Gapanovich
Keyword(s):  
Hemostatic Agent ◽  
Liver Bleeding

Fine Structure of Platelet Interaction with a New Microcrystalline Collagen Preparation

1974 ◽  
Vol 32 ◽  
pp. 58-59
Author(s):  
W. H. Zucker ◽  
R. G. Mason
Keyword(s):  
Fine Structure ◽  
Platelet Aggregation ◽  
Hydrochloric Acid ◽  
Whole Blood ◽  
Platelet Adhesion ◽  
Hemostatic Agent ◽  
Native Collagen ◽  
Fibrillar Morphology ◽  
Clinical Interest ◽  
New Form

Platelet adhesion initiates platelet aggregation and is an important component of the hemostatic process. Since the development of a new form of collagen as a topical hemostatic agent is of both basic and clinical interest, an ultrastructural and hematologic study of the interaction of platelets with the microcrystalline collagen preparation was undertaken.In this study, whole blood anticoagulated with EDTA was used in order to inhibit aggregation and permit study of platelet adhesion to collagen as an isolated event. The microcrystalline collagen was prepared from bovine dermal corium; milling was with sharp blades. The preparation consists of partial hydrochloric acid amine collagen salts and retains much of the fibrillar morphology of native collagen.

V1155: A Novel Application of a New Hemostatic Agent for the Management of Simulated Laparoscopic Trocar Injury

2005 ◽  
Vol 173 (4S) ◽  
pp. 313-314
Author(s):  
Mitchell R. Humphreys ◽  
Erik P. Castle ◽  
Paul E. Andrews ◽  
Mark H. Ereth ◽  
Matthew T. Gettman
Keyword(s):  
Hemostatic Agent ◽  
Laparoscopic Trocar ◽  
Trocar Injury

Managing Port-Site Bleeding during Less Invasive Coronary Artery Bypass Grafting

2012 ◽  
Vol 15 (5) ◽  
pp. 272 ◽  
Author(s):  
Soroosh Kiani ◽  
Mary-Lynn Brecht ◽  
Katherine Lovinger ◽  
Robert S. Poston
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Risk Score ◽  
Chest Tube ◽  
Artery Bypass ◽  
Hemostatic Agent ◽  
Bypass Grafting ◽  
Artery Bypass Grafting ◽  
Port Access

<p><b>Introduction:</b> Robotic-assisted coronary artery bypass grafting (r-CABG) requires the placement of ports bluntly through the chest wall. When removed, these ports create bleeding sites that can be difficult to detect and treat. This study evaluated whether a topical hemostatic agent placed locally within these sites helps to reduce bleeding and blood product requirements.</p><p><b>Methods:</b> We retrospectively analyzed outcomes for r-CABG cases where 5 mL of a flowable hemostatic agent was injected locally within all port sites (hemostat group, n = 62) compared with patients whose port sites were untreated (controls, n = 131). Outcomes included chest tube output, red blood cell (RBC) transfusions, length of hospital stay, and the risk of reoperation for bleeding. Analyses were adjusted for risk factors known to influence bleeding and Society of Thoracic Surgeons (STS) risk score as a weighted composite of variables, which controls for patient and clinical variables.</p><p><b>Results:</b> The 2 study groups had similar baseline characteristics and underwent the same r-CABG procedure. The hemostat group had significant reductions in RBC transfusion (24.2% versus 40.8% receiving blood; <i>P</i> = .026; 0.44 versus 1.39 U transfused postoperatively, <i>P</i> = .024). After adjustment for bleeding risks (using STS risk score), differences in transfusions remained significant. Reoperation rates for bleeding, length of stay, chest tube drainage, and intraoperative transfusions were not significantly different in the 2 groups.</p><p><b>Conclusions:</b> There was significantly reduced postoperative bleeding and less exposure to blood products in the hemostat group. These findings suggest that undetected bleeding from sites used for port access serves as an underappreciated source of morbidity after r-CABG.</p>

Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent

2021 ◽  
pp. 102570
Author(s):  
Mariana Ebert ◽  
Elmar Raquet ◽  
Sabine Schweisgut ◽  
Peter M. Schmidt ◽  
Thomas Weimer
Keyword(s):  
Coagulation Factor ◽  
Hemostatic Agent ◽  
Factor X

Origin and Use of Hydrogen Peroxide in Neurosurgery

Neurosurgery ◽  
2021 ◽  
Author(s):  
David Bailey ◽  
Elias B Rizk
Keyword(s):  
Hydrogen Peroxide ◽  
Hemostatic Agent ◽  
Medical Field ◽  
Wide Range ◽  
Actual Effectiveness ◽  
Fatal Complications

Abstract Hydrogen peroxide (H2O2) is a chemical with a wide range of applications. This includes its use in the medical field, in which its use has been ubiquitous but is most useful as an antiseptic and in achieving hemostasis. Neurosurgeons have been using H2O2 for well over a century, primarily for its hemostatic and antiseptic effects. This is in spite of the fact that the actual effectiveness of H2O2 as an antiseptic is questionable, and its use, in general, may be more dangerous than it appears. We review the application of H2O2 in medicine generally and, more specifically, in neurosurgery. This review outlines the reasoning behind the use of H2O2 as an antiseptic and details why it may not be as effective as one might think. We also detail its use as a hemostatic agent in neurosurgery, reviewing a number of techniques in which it has been useful in this role. Finally, we review the documented cases of complications associated with the use of H2O2 in neurosurgery. Ultimately, we conclude that the use of H2O2 in neurosurgery be reconsidered because of its lack of effectiveness as an antiseptic and potentially fatal complications.

A new surgical absorbable hemostatic agent

1960 ◽  
Vol 100 (3) ◽  
pp. 439-446 ◽  
Author(s):  
Elliott S. Hurwitt ◽  
John Henderson ◽  
Geoffrey H. Lord ◽  
George F. Gitlitz ◽  
Alvin Lebendiger
Keyword(s):  
Hemostatic Agent

The hemostatic agent ethamsylate promotes platelet/leukocyte aggregate formation in a model of vascular injury

2004 ◽  
Vol 18 (4) ◽  
pp. 423-430 ◽  
Author(s):  
Maria Rosa Hernandez ◽  
Miriam Alvarez-Guerra ◽  
Gines Escolar ◽  
Carlo Chiavaroli ◽  
Patrick Hannaert ◽  
...  
Keyword(s):  
Vascular Injury ◽  
Hemostatic Agent ◽  
Aggregate Formation
Sign in / Sign up

Export Citation Format

Share Document