Improving cord blood unit quantity and quality at King Abdullah International Medical Research Center Cord Blood Bank

Transfusion ◽  
2014 ◽  
Vol 54 (12) ◽  
pp. 3127-3130 ◽  
Author(s):  
Dunia Jawdat ◽  
Suha Arab ◽  
Hadeel Thahery ◽  
Walid Almashaqbeh ◽  
Ahmed Alaskar ◽  
...  
Keyword(s):  
Medical Research ◽  
Cord Blood ◽  
Blood Bank ◽  
International Medical ◽  
Research Center ◽  
International Medical Research ◽  
Blood Unit ◽  
Cord Blood Bank ◽  
Cord Blood Unit

scholarly journals Search for A Suitable Cord Blood Unit Including Two-Loci Mismatched Units at The Hokkaido Cord Blood Bank.

2000 ◽  
Vol 46 (1) ◽  
pp. 23-25
Author(s):  
Yuko Mogi ◽  
Norihiro Sato ◽  
Tatsuya Sekimoto ◽  
Kenji Ikebuchi ◽  
Hisami Ikeda ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Bank ◽  
Blood Unit ◽  
Cord Blood Bank ◽  
Cord Blood Unit

scholarly journals Optimization of the criteria for cord blood unit selection for transplantation in recipients of the different age groups: current view and prospects in Ukraine

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
P. Nemtinov ◽  
◽  
A. Ustymenko ◽  
G. Lobyntseva ◽  
L. Panchenko ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Age Groups ◽  
Blood Bank ◽  
Unit Selection ◽  
Blood Unit ◽  
Cord Blood Bank ◽  
Cord Blood Unit ◽  
Selection For

Umbilical cord blood has been widely used to treat both malignant and non-malignant hematological diseases for over 30 years. During this time, more than 40,000 successful hematopoietic stem cell (HSC) transplantations of umbilical cord blood have been performed. However, today in Ukraine there is no public umbilical cord blood bank established for unrelated HSC transplantation to patients with oncohematological disorders (both children and adults). In this regard, the HSC units must be purchased abroad or the patients are sent to foreign clinics for high-cost treatment. The organization of a public umbilical cord blood bank in Ukraine would help in a short time to meet the needs of patients with oncohematological disorders for donor HSCs for unrelated transplantation and save significant funds for the treatment of patients abroad. According to the experience of the world's leading oncohematological centers, when it is impossible to find either a related or haploidentical donor or in all available registries – a unrelated transplant, the search continues in the registers of public cord blood banks and an umbilical cord blood unit that matches the criteria is usually found. The optimal choice of umbilical cord blood unit is crucial to maximize the likelihood of successful transplant engraftment and recipient survival after the transplantation, so the criteria for cord blood unit selection for unrelated transplantation are a bit broader than those used when matching donor-recipient pairs. The review presents the main criteria for cord blood unit selection according to the assessment of its quality, cell dose, HLA matching for unrelated transplantation to recipients of different age groups in accordance with international guidelines developed by the National Marrow Donor Program (NMDP), USA Center for International Blood and Brain Transplantation Research (CIBMTR), in collaboration with the NMDP Council Advisory Group, as well as in accordance with the American Society for Transplantation and Cellular Therapy (ASTCT) and the Seventh Edition of the NetCord-FACT International Standards for Cord Blood Collection, Banking, and Release for Administration.

scholarly journals Cord blood unit factors influencing transplant outcomes from the Asian multiethnic Singapore Cord Blood Bank

2015 ◽  
Vol 50 (9) ◽  
pp. 1256-1258 ◽  
Author(s):  
S-Y Ong ◽  
C Phipps ◽  
P Chu ◽  
A Prasath ◽  
A Y L Ho ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Bank ◽  
Blood Unit ◽  
Transplant Outcomes ◽  
Cord Blood Bank ◽  
Factors Influencing ◽  
Cord Blood Unit

An Empiric Model for Defining A Suitable Cord Blood Inventory Size in Brazil Using an HLA Matching Computer Program.

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3834-3834
Author(s):  
Andreza Ribiero ◽  
Margareth Afonso Torres ◽  
Marcos Alberto Piani ◽  
Maria Elisa Moraes ◽  
Jose Mauro Kutner ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Computer Program ◽  
Cord Blood ◽  
Cell Transplantation ◽  
Albert Einstein ◽  
Blood Bank ◽  
Blood Unit ◽  
Cord Blood Unit ◽  
Hla Compatibility

Abstract Abstract 3834 Introduction: Umbilical cord blood represents an alternative for patients who need Hematopoietic Cell Transplants and cannot rely on identical HLA donors. The Brazilian public cord blood consortium has been operating since 2002 with six centers to date, including the Cord Blood Bank at Albert Einstein Hospital, Sao Paulo, Brazil. However, currently there are no studies concerning the optimal size of a cord blood inventory in our country. It is difficult to define the inventory size due to the different possible levels of HLA compatibility and the minimum cellularity required for transplantation. Objective: To estimate the minimum number of cord blood units that should be stored in Brazil in order to adequately provide 4/6, 5/6 and 6/6 HLA-A, -B, -DRB1 matches for a significant percentage of patients who need stem cell transplantation. Methods: A computer program was developed to match HLA compatibilities between a group of 904 patients searching for unrelated stem cell transplantation and a database of over 10,500 Volunteer Unrelated Donors (VUD) and 1,018 cord blood units stored in the Albert Einstein Hospital Cord Bank. In sequence, the number of units necessary for different levels of matches was estimated. This database consisted of HLA-A, -B and -DRB1 typed with low resolution for class I and high resolution for class II. The sequence of individual units in the DATABASE was randomized in order to avoid any bias in the analyses caused by data clustering. Both groups of donors and patients came from varied ethnical backgrounds and live in the state of Sao Paulo, Brazil. The program compared each patient phenotype with the phenotypes of database subgroups of increasing size (500 to 11,500 at 1,000 intervals). The results were then analyzed according to: a) Likelihood of finding 4/6, 5/6, 6/6 matches using at least one cord blood unit for each patient; b) Likelihood of finding at least four compatible cord units (ie, multiple) per match for each patient. Results: For a minimum 4/6 match using at least one cord blood unit, over 82% of patients were able to find suitable units within an inventory size of 1,500 cords. That percentage raised to over 95% by increasing the inventory size to 5,500 cords. The curve grew asymptotically from that point onwards. When at least four cord units were required at the same compatibility level (4/6), over 90% of patients were able to find suitable units within an inventory size of 11,500 cords With more restrictive (5/6 or 6/6) matching requirements using at least one cord blood unit, 61,3% of patients were able to find suitable unit within an inventory size of 11,500 cords. When at least four cord units with a minimum of 5/6 match were required, only 22,8% of patients will find these amount of units in a bank with 11.500 stored units. An estimate of the need of stored cord blood units based on these analyses suggests that, considering the same genetic distribution of donors, and taking into account that only 21% of the inventory of our bank would provide > 3,0×10E7 TCN for an adult or multiple cord units for an adequate cell dosage, more than 58.000 units would be necessary to find a suitable unit with 5/6 match for 61,3% of patients. Conclusions: Despite the high degree of variability of the HLA phenotype in the studied population, it was possible to find a suitable matched cord blood unit within a relatively small inventory. That finding is true only for a low HLA compatibility level. Indeed, with only 2,600 stored units, Albert Einstein's Blood Bank has already sent 70 units for transplantation, mostly for children. However, when a higher degree of compatibility and/or a higher cellularity are necessary, the number of units in the database increases drastically. This study suggests that a minimum inventory of 58,000 cord blood units would be necessary to find a suitable match for almost two thirds of the Brazilian population. Finally, it's important to mention that this study is based on a relatively small sample and should be tested in larger studies including rare phenotypes and ethnic minorities. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Non-Inherited Maternal Antigens Identify Acceptable HLA Mismatches: A New Policy for the Hellenic Cord Blood Bank

2018 ◽  
Vol 5 (4) ◽  
pp. 77 ◽  
Author(s):  
Effrosyni Panagouli ◽  
Amalia Dinou ◽  
Panagiotis Mallis ◽  
Efstathios Michalopoulos ◽  
Andreas Papassavas ◽  
...  
Keyword(s):  
Cord Blood ◽  
Human Leukocyte ◽  
Blood Bank ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Cord Blood Bank ◽  
Cord Blood Unit ◽  
Set Up ◽  
Microsoft Office ◽  
Hla Mismatches

Background: During pregnancy, the maternal-fetal contact may lead to the development of tolerance against the maternal human leukocyte antigen (HLA) that is not inherited by the fetus. These non-inherited maternal antigens (NIMAs) define acceptable HLA mismatches; therefore, the number of HLA phenotypes that are suitable matches for patients who need a hematopoietic stem cell transplant could be increased. Cord blood unit (CBU) transplantations to patients mismatched for a HLA loci, but similar to the ΝΙΜAs of the CBU, have a prognosis similar to 6/6-matched ones. Methods: The Hellenic Cord Blood Bank (HCBB) identified the maternal HLA of 380 cord blood donors, specifying the NIMA haplotypes of the related cryostored CBUs. Results: The HCBB extended the pool of HLA phenotypes through the generation of unique virtual phenotypes (VPs). A “VP database” was set up, using Microsoft Office—Access™, in order to provide NIMA-matched CBUs for potential recipients. The effectiveness of VPs’ matching was tested in 80 Greek patients. Conclusion: This methodology may contribute to the increase of the number of available CBUs for patients, in the case where there is no available CBU, or in case an additional one is needed. Through this method, the CBUs could be used faster and more effectively, rather than being cryostored for long periods of time.

scholarly journals Stem Cell Research and Regenerative Medicine at King Abdullah International Medical Research Center

2014 ◽  
Vol 23 (S1) ◽  
pp. 12-16 ◽  
Author(s):  
Mohamed H. Abumaree ◽  
Ahmed S. Al Askar ◽  
Bill Kalionis ◽  
Fawaz Mohamed Abomaray ◽  
Dunia Jawdat ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Medical Research ◽  
Stem Cell Research ◽  
International Medical ◽  
Research Center ◽  
International Medical Research

General News

2004 ◽  
Vol 08 (05) ◽  
pp. 269-275
Keyword(s):  
Cord Blood ◽  
Blood Bank ◽  
Biomedical Sciences ◽  
Bird Flu ◽  
Cord Blood Bank ◽  
Flu Virus

India Ranked First in DMF Filings in 2003. Bird Flu Virus in Japan Infectious to Humans. Singapore’s Conducive Biomedical Sciences Environment. Singapore’s First Public Cord Blood Bank.

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