Fresh-frozen plasma transfusion did not reduce 30-day mortality in patients undergoing cardiopulmonary bypass cardiac surgery with excessive bleeding: the PLASMACARD multicenter cohort study

Transfusion ◽  
2013 ◽  
Vol 54 (4) ◽  
pp. 1114-1124 ◽  
Author(s):  
Adélaïde Doussau ◽  
Paul Perez ◽  
Maryse Puntous ◽  
Joachim Calderon ◽  
Michel Jeanne ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cohort Study ◽  
Cardiopulmonary Bypass ◽  
Fresh Frozen Plasma ◽  
Plasma Transfusion ◽  
Multicenter Cohort Study ◽  
Excessive Bleeding ◽  
Multicenter Cohort ◽  
Fresh Frozen ◽  
Frozen Plasma

Fresh Frozen Plasma Transfusion in Acute Variceal Hemorrhage: Results from a Multicenter Cohort Study

2021 ◽  
Author(s):  
Arpan Mohanty ◽  
Devika Kapuria ◽  
Andrew Canakis ◽  
Honghuang Lin ◽  
Maelys J. Amat ◽  
...  
Keyword(s):  
Cohort Study ◽  
Fresh Frozen Plasma ◽  
Variceal Hemorrhage ◽  
Plasma Transfusion ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals An Exploratory Cohort Study Comparing Prothrombin Complex Concentrate and Fresh Frozen Plasma for the Treatment of Coagulopathy After Complex Cardiac Surgery

2015 ◽  
Vol 121 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Erik Ortmann ◽  
Martin W. Besser ◽  
Linda D. Sharples ◽  
Caroline Gerrard ◽  
Marius Berman ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cohort Study ◽  
Prothrombin Complex Concentrate ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

Utility of Whole Blood Hemostatometry Using the Clot Signature Analyzer®for Assessment of Hemostasis in Cardiac Surgery

2002 ◽  
Vol 96 (5) ◽  
pp. 1115-1122 ◽  
Author(s):  
Nauder Faraday ◽  
Eliseo Guallar ◽  
Valerie A. Sera ◽  
Everlie D. Bolton ◽  
Robert B. Scharpf ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Whole Blood ◽  
Thrombus Formation ◽  
Fresh Frozen Plasma ◽  
Fibrinogen Concentration ◽  
Plasma Transfusion ◽  
Predictive Values ◽  
Signature Analyzer ◽  
Fresh Frozen ◽  
Frozen Plasma

Background A hemostatic monitor capable of rapid, accurate detection of clinical coagulopathy within the operating room could improve management of bleeding after cardiopulmonary bypass (CPB). The Clot Signature Analyzer is a hemostatometer that measures global hemostasis in whole blood. The authors hypothesized that point-of-care hemostatometry could detect a clinical coagulopathic state in cardiac surgical patients. Methods Fifty-seven adult patients scheduled for a variety of elective cardiac surgical procedures were studied. Anesthesia, CPB, heparin anticoagulation, protamine reversal, and transfusion for post-CPB bleeding were all managed by standardized protocol. Clinical coagulopathy was defined by the need for platelet or fresh frozen plasma transfusion. The Clot Signature Analyzer collagen-induced thrombus formation (CITF) assay measured platelet-mediated hemostasis in vitro. The activated clotting time, platelet count, prothrombin time, activated partial thromboplastin time, and fibrinogen concentration were also measured. Results The postprotamine CITF was greater in patients who required hemostatic transfusion than in those who did not (17.6 +/- 8.0 min vs. 10.5 +/- 5.7 min, respectively; P < 0.01). Postprotamine CITF values were highly correlated with platelet and fresh frozen plasma transfusion (Spearman r = 0.50, P < 0.001 and r = 0.40, P < 0.005, respectively). Receiver operator characteristic curves showed a highly significant relation between the postprotamine CITF and intraoperative platelet and fresh frozen plasma transfusion (area under the curve, 0.78-0.81, P < 0.005) with 60-80% sensitivity, specificity, positive and negative predictive values at cutoffs of 12-14 min. Logistic regression demonstrated that the CITF was independently predictive of post-CPB hemostatic transfusion, but standard hemostatic assays were not. Conclusions The Clot Signature Analyzer CITF detects a clinical coagulopathic state after CPB and is independently predictive of the need for hemostatic transfusion. Hemostatometry has potential utility for monitoring hemostasis in cardiac surgery.

scholarly journals Reevaluating the Importance of Modified Ultrafiltration in Contemporary Pediatric Cardiac Surgery

2018 ◽  
Vol 7 (12) ◽  
pp. 498 ◽  
Author(s):  
Vladimir Milovanovic ◽  
Dejan Bisenic ◽  
Branko Mimic ◽  
Bilal Ali ◽  
Massimiliano Cantinotti ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Positive Impact ◽  
Fresh Frozen Plasma ◽  
Pediatric Cardiac Surgery ◽  
Packed Red Blood Cells ◽  
Hemodynamic State ◽  
Fresh Frozen ◽  
Chest Tube Output ◽  
Frozen Plasma

Objective(s): Modified ultrafiltration has gained wide acceptance as a powerful tool against cardiopulmonary bypass morbidity in pediatric cardiac surgery. The aim of our study was to assess the importance of modified ultrafiltration within conditions of contemporary cardiopulmonary bypass characteristics. Methods: Ninety–eight patients (overall cohort) weighing less than 12 kg undergoing surgical repair with cardiopulmonary bypass were prospectively enrolled in a randomized protocol to receive modified and conventional ultrafiltration (MUF group) or just conventional ultrafiltration (non-MUF group). A special attention was paid to forty-nine neonates and infants weighing less than 5 kg (lower weight (LW) cohort). Results: Post-filtration hematocrit was significantly higher in the MUF group for both cohorts (overall cohort p = 0.001; LW cohort p = 0.04), but not at other time points. During the postoperative course, patients in the MUF group received fewer packed red blood cells, (overall cohort p = 0.01; LW cohort p = 0.07), but required more fresh frozen plasma (overall cohort p = 0.04; LW cohort p = 0.05). There was no difference between groups in hemodynamic state, chest tube output, duration of mechanical ventilation, respiratory parameters, duration of intensive care unit, and hospitalization stay. Conclusions: If conventional ultrafiltration provides adequate hemoconcentration modified ultrafiltration does not provide additional positive benefits except for reduction in blood cell transfusion, This, however, comes at the cost of needing more fresh frozen plasma. Of particular importance is that this also applies to infants with weight bellow 5 kg where modified ultrafiltration was supposed to have the greatest positive impact.

scholarly journals Clinical decision versus thromboelastometry based fresh frozen plasma transfusion in cardiac surgery

2017 ◽  
Vol 118 (3) ◽  
pp. 458-459 ◽  
Author(s):  
M.I. Meesters ◽  
N.J. Koning ◽  
J.W.A. Romijn ◽  
S.A. Loer ◽  
C Boer
Keyword(s):  
Cardiac Surgery ◽  
Clinical Decision ◽  
Fresh Frozen Plasma ◽  
Plasma Transfusion ◽  
Fresh Frozen ◽  
Frozen Plasma
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