Implementation of an intraoperative blood transport and storage initiative and its effect on reducing red blood cell and plasma waste

Transfusion ◽  
2013 ◽  
Vol 54 (3) ◽  
pp. 701-707 ◽  
Author(s):  
Michael J. Brown ◽  
Lisa M. Button ◽  
Karafa S. Badjie ◽  
Jean M. Guyer ◽  
Sarah R. Dhanorker ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Cell And Plasma ◽  
Blood Transport ◽  
And Storage

scholarly journals Red‐blood‐cell manufacturing methods and storage solutions differentially induce pulmonary cell activation

Vox Sanguinis ◽  
2020 ◽  
Vol 115 (5) ◽  
pp. 395-404 ◽  
Author(s):  
Mathijs R. Wirtz ◽  
Ruqayyah J. Almizraq ◽  
Nina C. Weber ◽  
Philip J. Norris ◽  
Suchitra Pandey ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Activation ◽  
Cell Manufacturing ◽  
Storage Solutions ◽  
Manufacturing Methods ◽  
And Storage

Red blood cell (RBC) age at collection and storage influences RBC membrane-associated carbohydrates and lectin binding

Transfusion ◽  
2007 ◽  
Vol 47 (6) ◽  
pp. 966-968 ◽  
Author(s):  
Rosemary L. Sparrow ◽  
Margaret F. Veale ◽  
Geraldine Healey ◽  
Katherine A. Payne
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Lectin Binding ◽  
Rbc Membrane ◽  
And Storage

scholarly journals Processing methods and storage duration impact extracellular vesicle counts in red blood cell units

2020 ◽  
Vol 4 (21) ◽  
pp. 5527-5539
Author(s):  
Clementine Gamonet ◽  
Maxime Desmarets ◽  
Guillaume Mourey ◽  
Sabeha Biichle ◽  
Sophie Aupet ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Annexin V ◽  
Analysis Of Covariance ◽  
Active Components ◽  
Storage Duration ◽  
Processing Methods ◽  
Controllable Factors ◽  
Filter Type ◽  
And Storage

Abstract Extracellular vesicles (EVs) are active components of red blood cell (RBC) concentrates and may be associated with beneficial and adverse effects of transfusion. Elucidating controllable factors associated with EV release in RBC products is thus important to better manage the quality and properties of RBC units. Erythrocyte-derived EVs (EEVs) and platelet-derived EVs (PEVs) were counted in 1226 RBC units (administered to 280 patients) using a standardized cytometry-based method. EV size and CD47 and annexin V expression were also measured. The effects of donor characteristics, processing methods, and storage duration on EV counts were analyzed by using standard comparison tests, and analysis of covariance was used to determine factors independently associated with EV counts. PEV as well as EEV counts were higher in whole-blood–filtered RBC units compared with RBC-filtered units; PEV counts were associated with filter type (higher with filters associated with higher residual platelets), and CD47 expression was higher on EEVs in RBC units stored longer. Multivariate analysis showed that EEV counts were strongly associated with filter type (P < .0001), preparation, and storage time (+25.4 EEV/µL per day [P = .01] and +42.4 EEV/µL per day [P < .0001], respectively). The only independent factor associated with PEV counts was the residual platelet count in the unit (+67.1 PEV/µL; P < .0001). Overall, processing methods have an impact on EV counts and characteristics, leading to large variations in EV quantities transfused into patients. RBC unit processing methods might be standardized to control the EV content of RBC units if any impacts on patient outcomes can be confirmed. The IMIB (Impact of Microparticles in Blood) study is ancillary to the French ABLE (Age of Transfused Blood in Critically Ill Adults) trial (ISRCTN44878718).

Influence of hematocrit on whole blood glucose levels: new evidence from marine mammals

1989 ◽  
Vol 256 (6) ◽  
pp. R1220-R1224 ◽  
Author(s):  
M. A. Castellini ◽  
J. M. Castellini
Keyword(s):  
Blood Glucose ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Glucose Concentration ◽  
Whole Blood ◽  
Marine Mammals ◽  
Mammalian Species ◽  
Regulatory Pathways ◽  
Glucose Levels ◽  
Blood Cell And Plasma

The water content and glucose concentration in the whole blood of marine mammals were found to be correlated to red blood cell concentration. Because hematocrit (Hct) undergoes significant periodic shifts in these mammals during periods of apnea and/or diving, the measured values of whole blood glucose change due to alterations in Hct, independent of shifts in metabolite regulatory pathways. In contrast to humans, where red blood cell and plasma glucose concentrations are equivalent, in most other mammalian species red blood cell glucose concentration is much lower than that in plasma. Therefore, as Hct increases, the whole blood concentration of glucose must decrease in a linear manner, depending on the magnitude of the Hct change and the concentration of glucose in the blood cells. This study demonstrates that water and metabolite distribution must be considered when interpreting whole blood metabolite data. The results suggest that plasma or serum analysis of metabolites would avoid distribution problems. This is especially critical in species where Hct varies during the course of the experiment, as in exercising or diving mammals.

scholarly journals Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III—Omics

Transfusion ◽  
2018 ◽  
Vol 59 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Angelo D'Alessandro ◽  
Rachel Culp‐Hill ◽  
Julie A. Reisz ◽  
Mikayla Anderson ◽  
Xiaoyun Fu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Storage Time ◽  
Cell Metabolism ◽  
Blood Processing ◽  
Processing And Storage ◽  
And Storage
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