scholarly journals Ascertainment of iron deficiency and depletion in blood donors through screening questions for pica and restless legs syndrome

Transfusion ◽  
2013 ◽  
Vol 53 (8) ◽  
pp. 1637-1644 ◽  
Author(s):  
Barbara J. Bryant ◽  
Yu Ying Yau ◽  
Sarah M. Arceo ◽  
Julie A. Hopkins ◽  
Susan F. Leitman
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Restless Legs ◽  
Screening Questions

Ascertainment of Iron Depletion and Deficiency in Blood Donors Through Screening Questions for Pica and Restless Legs Syndrome.

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2283-2283
Author(s):  
Barbara J. Bryant ◽  
Yu Ying Yau ◽  
Sarah M. Arceo ◽  
Julie A. Hopkins ◽  
Susan F. Leitman
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Oral Iron ◽  
Iron Therapy ◽  
Iron Depletion ◽  
Restless Legs ◽  
Iron Deficient ◽  
Screening Questions ◽  
Iron Replacement

Abstract Abstract 2283 Background: Pica and restless legs syndrome (RLS) are associated with iron depletion and deficiency. Pica refers to the compulsive craving for and persistent consumption of non-nutritive substances. Pagophagia, the pathological consumption of ice, is a specific pica strongly associated with iron deficiency. RLS is a neurological movement disorder characterized by uncomfortable sensations in the lower extremities, with a compelling urge to move the extremities to relieve the discomfort. Primary RLS is a central nervous system disorder; however, secondary RLS may be caused or exacerbated by iron deficiency. The purpose of this study was to prospectively assess the prevalence of pica and RLS in blood donors presenting to a hospital-based donor center, to correlate the findings with donor hemoglobin and iron levels, and to study the effects of oral iron replacement on the resolution of symptoms. Methods: During a 39-month period, 1236 blood donors deferred for fingerstick hemoglobin <12.5 g/dL and 400 non-deferred “control” donors underwent health screening and laboratory testing (CBC, ferritin, iron, transferrin). Iron deficiency was defined as a ferritin level below the institutional reference range of 9 mcg/L in females and 18 mcg/L in males. Iron depletion was defined as a ferritin of 9 – 19 mcg/L in females and 18 – 29 mcg/L in males. Pica and RLS were assessed by direct questioning. Deferred donors and iron-deficient control donors were given ferrous sulfate 325 mg daily for 60 days. Reassessments were performed and additional iron tablets dispensed at subsequent visits. Results: Pica was reported in 11% of donors with iron depletion/deficiency, compared with 4% of iron-replete donors (p<0.0001). The prevalence of pica rose to 21% in females with ferritin <9 mcg/L. Pagophagia (ice pica) was most common and was often of extraordinary intensity, with characteristics of an addiction. Donors with pagophagia given iron reported a marked reduction in the desire to eat ice by day 5–8 of therapy, with disappearance of symptoms by day 10–14. RLS was reported in 16% of subjects with iron depletion/deficiency compared with 11% of iron-replete donors (p=0.012). Iron replacement generally resulted in improvement of RLS symptoms, however, at least 4–6 weeks of iron therapy was necessary. The positive predictive values of pica and RLS in iron deficient/depleted blood donors were 73% and 58%, respectively. Conclusion: The presence of pica is highly predictive of iron depletion/deficiency in blood donors; however, RLS lacks a strong correlation in this population. Screening questions for pica, in particular pagophagia, may be useful in the ascertainment of iron depletion and deficiency in blood donors and may identify those who would benefit from oral iron therapy. Disclosures: No relevant conflicts of interest to declare.

scholarly journals The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1313
Author(s):  
Susanne Macher ◽  
Cornelia Herster ◽  
Magdalena Holter ◽  
Martina Moritz ◽  
Eva Maria Matzhold ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Iron Supplementation ◽  
Blood Donors ◽  
Secondary Analysis ◽  
Chronic Fatigue ◽  
Oral Iron ◽  
Restless Legs ◽  
Fatigue Syndrome ◽  
Iron Deficient

Background: Besides anemia, iron deficiency may cause more subtle symptoms, including the restless legs syndrome (RLS), the chronic fatigue syndrome (CFS) or sleeping disorders. Objective: The aim of this pre-planned secondary analysis of the IronWoMan randomized controlled trial (RCT) was to compare the frequency and severity of symptoms associated with iron deficiency before and after (intravenous or oral) iron supplementation in iron deficient blood donors. Methods/Design: Prospective, randomized, controlled, single-centre trial. (ClinicalTrials.gov: NCT01787526). Setting: Tertiary care center in Graz, Austria. Participants: 176 (138 female and 38 male) whole-blood and platelet apheresis donors aged ≥ 18 and ≤ 65 years with iron deficiency (ferritin ≤ 30ng/mL at the time of blood donation). Interventions: Intravenous iron (1 g ferric carboxymaltose, n = 86) or oral iron supplementation (10 g iron fumarate, 100 capsules, n = 90). Measurements: Clinical symptoms were evaluated by a survey before iron therapy (visit 0, V0) and after 8–12 weeks (visit 1, V1), including questions about symptoms of restless legs syndrome (RLS), chronic fatigue syndrome (CFS), sleeping disorders, quality of life and symptoms like headaches, dyspnoea, dizziness, palpitations, pica and trophic changes in fingernails or hair. Results: We found a significant improvement in the severity of symptoms for RLS, fatigue and sleep quality (p < 0.001). Furthermore, a significant decrease in headaches, dyspnoea, dizziness and palpitations was reported (p < 0.05). There was no difference between the type of iron supplementation (intravenous versus oral) and clinical outcome data. Conclusion: Iron supplementation in iron-deficient blood donors may be an effective strategy to improve symptoms related to iron deficiency and the wellbeing of blood donors.

scholarly journals Restless legs syndrome and iron deficiency in adults with attention-deficit/hyperactivity disorder

SLEEP ◽  
2019 ◽  
Vol 42 (5) ◽  
Author(s):  
Régis Lopez ◽  
Jean-Arthur Micoulaud Franchi ◽  
Sofiene Chenini ◽  
Marie Gachet ◽  
Isabelle Jaussent ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Attention Deficit ◽  
Restless Legs ◽  
Hyperactivity Disorder

SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome

2020 ◽  
Vol 81 ◽  
pp. 12-17
Author(s):  
Xiao-Ying Zhu ◽  
Hong-Ming Wang ◽  
Ting-Ting Wu ◽  
Te Liu ◽  
Ya-Jing Chen ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Restless Legs

Multiregional brain iron deficiency in restless legs syndrome

2008 ◽  
Vol 23 (8) ◽  
pp. 1184-1187 ◽  
Author(s):  
Jana Godau ◽  
Uwe Klose ◽  
Adriana Di Santo ◽  
Katherine Schweitzer ◽  
Daniela Berg
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Brain Iron ◽  
Restless Legs

Restless legs syndrome in blood donors

2004 ◽  
Vol 5 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Jan Ulfberg ◽  
Birgitta Nyström
Keyword(s):  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Restless Legs

Restless legs syndrome in pregnancy is connected with iron deficiency

2015 ◽  
Vol 16 (5) ◽  
pp. 589-592 ◽  
Author(s):  
Michal Minár ◽  
Zuzana Košutzká ◽  
Hana Habánová ◽  
Igor Rusňák ◽  
Karol Planck ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Restless Legs ◽  
In Pregnancy

scholarly journals Medical Case Report on Repeat Treatment of Restless Legs Syndrome with Intravenous Infusion of Iron

2021 ◽  
pp. 578-583
Author(s):  
Katherine Condon ◽  
James Chipman
Keyword(s):  
Case Report ◽  
Iron Deficiency ◽  
Substantia Nigra ◽  
Restless Legs Syndrome ◽  
Intravenous Iron ◽  
Significant Negative Correlation ◽  
Ferric Carboxymaltose ◽  
Medical Interventions ◽  
Restless Legs ◽  
Medical Case Report

Restless legs syndrome (RLS) is a debilitating neurological disorder for which a range of medical interventions with varied efficacy has been employed. Based on evidence of iron deficiency in the substantia nigra of the midbrain, there are reports of substantial benefits from intravenous iron infusion. This case report demonstrates a strong statistically significant negative correlation between serum ferritin and RLS severity of symptoms in a subject with RLS who received 2 intravenous infusions of ferric carboxymaltose over a period of 464 days. The results provide further evidence to support the treatment strategy.

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