scholarly journals Efficient cell delivery mediated by lipid-specific endosomal escape of supercharged branched peptides

Traffic ◽  
2018 ◽  
Vol 19 (6) ◽  
pp. 421-435 ◽  
Author(s):  
Dakota J. Brock ◽  
Lauren Kustigian ◽  
Mengqiu Jiang ◽  
Kristin Graham ◽  
Ting-Yi Wang ◽  
...  
Keyword(s):  
Endosomal Escape ◽  
Cell Delivery ◽  
Branched Peptides

scholarly journals Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair

2019 ◽  
Vol 14 (3) ◽  
pp. 034104 ◽  
Author(s):  
Raquel Costa-Almeida ◽  
Isabel Calejo ◽  
Roberta Altieri ◽  
Rui M A Domingues ◽  
Emanuele Giordano ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Platelet Lysate ◽  
Cell Delivery

Delivery of Cas13a/crRNA by self-degradable black phosphorus nanosheets to specifically inhibit Mcl-1 for breast cancer therapy

2020 ◽  
Vol 8 (48) ◽  
pp. 11096-11106
Author(s):  
Huahua Yue ◽  
Ru Huang ◽  
Yuanyue Shan ◽  
Da Xing
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Black Phosphorus ◽  
Endosomal Escape ◽  
Transcriptional Level ◽  
Breast Cancer Therapy

The constructed Cas13a/crRNA complex is delivered into cytoplasm by PBP via endocytosis, followed by endosomal escape based on biodegradation of the PBP, and efficiently knocked down Mcl-1 at transcriptional level for breast cancer therapy.

scholarly journals Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair

2021 ◽  
Vol 22 (3) ◽  
pp. 1201
Author(s):  
Hsuan Peng ◽  
Kazuhiro Shindo ◽  
Renée R. Donahue ◽  
Ahmed Abdel-Latif
Keyword(s):  
Stem Cell ◽  
Immune Responses ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Clinical Evidence ◽  
Current Knowledge ◽  
Cell Delivery ◽  
Cardiac Cell Therapy ◽  
Stem Cell Treatment

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape

2021 ◽  
Author(s):  
Ji Eun Lee ◽  
Yeo Wool Kang ◽  
Kyung Hee Jung ◽  
Mi Kwon Son ◽  
Seung-Min Shin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Specific Antibody ◽  
Endosomal Escape

scholarly journals Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1861
Author(s):  
Armin Mooranian ◽  
Melissa Jones ◽  
Corina Mihaela Ionescu ◽  
Daniel Walker ◽  
Susbin Raj Wagle ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Viable Cell ◽  
Cell Delivery ◽  
Artificial Organ ◽  
Bioartificial Pancreas ◽  
Advantages And Disadvantages ◽  
Wide Range ◽  
Bioartificial Organs ◽  
Significant Interest ◽  
Modern Technologies

The utilisation of bioartificial organs is of significant interest to many due to their versatility in treating a wide range of disorders. Microencapsulation has a potentially significant role in such organs. In order to utilise microcapsules, accurate characterisation and analysis is required to assess their properties and suitability. Bioartificial organs or transplantable microdevices must also account for immunogenic considerations, which will be discussed in detail. One of the most characterized cases is the investigation into a bioartificial pancreas, including using microencapsulation of islets or other cells, and will be the focus subject of this review. Overall, this review will discuss the traditional and modern technologies which are necessary for the characterisation of properties for transplantable microdevices or organs, summarizing analysis of the microcapsule itself, cells and finally a working organ. Furthermore, immunogenic considerations of such organs are another important aspect which is addressed within this review. The various techniques, methodologies, advantages, and disadvantages will all be discussed. Hence, the purpose of this review is providing an updated examination of all processes for the analysis of a working, biocompatible artificial organ.

scholarly journals Conformal Fabrication of an Electrospun Nanofiber Mat on a 3D Ear Cartilage-Shaped Hydrogel Collector Based on Hydrogel-Assisted Electrospinning

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jin Yeong Song ◽  
Hyun Il Ryu ◽  
Jeong Myeong Lee ◽  
Seong Hwan Bae ◽  
Jae Woo Lee ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Electrospun Nanofibers ◽  
Cell Delivery ◽  
Complex Geometries ◽  
Two Dimensional ◽  
Uniform Thickness ◽  
Electrospun Nanofiber ◽  
Electrospinning Technique ◽  
Ear Cartilage ◽  
Focused Electric Field

AbstractElectrospinning is a common and versatile process to produce nanofibers and deposit them on a collector as a two-dimensional nanofiber mat or a three-dimensional (3D) macroscopic arrangement. However, 3D electroconductive collectors with complex geometries, including protruded, curved, and recessed regions, generally caused hampering of a conformal deposition and incomplete covering of electrospun nanofibers. In this study, we suggested a conformal fabrication of an electrospun nanofiber mat on a 3D ear cartilage-shaped hydrogel collector based on hydrogel-assisted electrospinning. To relieve the influence of the complex geometries, we flattened the protruded parts of the 3D ear cartilage-shaped hydrogel collector by exploiting the flexibility of the hydrogel. We found that the suggested fabrication technique could significantly decrease an unevenly focused electric field, caused by the complex geometries of the 3D collector, by alleviating the standard deviation by more than 70% through numerical simulation. Furthermore, it was experimentally confirmed that an electrospun nanofiber mat conformally covered the flattened hydrogel collector with a uniform thickness, which was not achieved with the original hydrogel collector. Given that this study established the conformal electrospinning technique on 3D electroconductive collectors, it will contribute to various studies related to electrospinning, including tissue engineering, drug/cell delivery, environmental filter, and clothing.

scholarly journals Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice

2021 ◽  
Vol 476 (5) ◽  
pp. 2135-2148
Author(s):  
Yibing Nong ◽  
Yiru Guo ◽  
Alex Tomlin ◽  
Xiaoping Zhu ◽  
Marcin Wysoczynski ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Cell Delivery ◽  
A Cell ◽  
Delivery Approach

Application of chloroquine as an endosomal escape enhancing agent: new frontiers for an old drug

2021 ◽  
pp. 1-13
Author(s):  
Mohammad Hajimolaali ◽  
Hosein Mohammadian ◽  
Ali Torabi ◽  
Amin Shirini ◽  
Mostafa Khalife Shal ◽  
...  
Keyword(s):  
Endosomal Escape
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