scholarly journals More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation-independent cellular defects

Traffic ◽  
2018 ◽  
Vol 19 (6) ◽  
pp. 463-480 ◽  
Author(s):  
Jessica B. Blackburn ◽  
Tetyana Kudlyk ◽  
Irina Pokrovskaya ◽  
Vladimir V. Lupashin
Keyword(s):  
Golgi Complex ◽  
Complex Deficiency ◽  
Conserved Oligomeric Golgi Complex ◽  
Conserved Oligomeric Golgi

scholarly journals The ER v-SNAREs are required for GPI-anchored protein sorting from other secretory proteins upon exit from the ER

2003 ◽  
Vol 162 (3) ◽  
pp. 403-412 ◽  
Author(s):  
Pierre Morsomme ◽  
Cristina Prescianotto-Baschong ◽  
Howard Riezman
Keyword(s):  
Golgi Complex ◽  
Protein Sorting ◽  
Secretory Proteins ◽  
Rab Gtpase ◽  
Cargo Protein ◽  
Conserved Oligomeric Golgi Complex ◽  
Sorting Process ◽  
Conserved Oligomeric Golgi

Glycosylphosphatidylinositol (GPI)-anchored proteins exit the ER in distinct vesicles from other secretory proteins, and this sorting event requires the Rab GTPase Ypt1p, tethering factors Uso1p, and the conserved oligomeric Golgi complex. Here we show that proper sorting depended on the vSNAREs, Bos1p, Bet1p, and Sec22p. However, the t-SNARE Sed5p was not required for protein sorting upon ER exit. Moreover, the sorting defect observed in vitro with bos1–1 extracts was also observed in vivo and was visualized by EM. Finally, transport and maturation of the GPI-anchored protein Gas1p was specifically affected in a bos1–1 mutant at semirestrictive temperature. Therefore, we propose that v-SNAREs are part of the cargo protein sorting machinery upon exit from the ER and that a correct sorting process is necessary for proper maturation of GPI-anchored proteins.

scholarly journals Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery

Glycobiology ◽  
2011 ◽  
Vol 21 (12) ◽  
pp. 1554-1569 ◽  
Author(s):  
Irina D Pokrovskaya ◽  
Rose Willett ◽  
Richard D Smith ◽  
Willy Morelle ◽  
Tetyana Kudlyk ◽  
...  
Keyword(s):  
Golgi Complex ◽  
Conserved Oligomeric Golgi Complex ◽  
Conserved Oligomeric Golgi

scholarly journals Structural Analysis of Conserved Oligomeric Golgi Complex Subunit 2

2007 ◽  
Vol 282 (32) ◽  
pp. 23418-23426 ◽  
Author(s):  
Lorraine F. Cavanaugh ◽  
Xiaocheng Chen ◽  
Brian C. Richardson ◽  
Daniel Ungar ◽  
Istvan Pelczer ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Golgi Complex ◽  
Conserved Oligomeric Golgi Complex ◽  
Conserved Oligomeric Golgi
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